PTEN: a new guardian of the genome. (Q37270432)

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14 January 2020

review article

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title

PTEN: a new guardian of the genome (English)

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14 January 2020

2

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14 January 2020

author name string

Y Yin

series ordinal

1

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14 January 2020

language of work or name

English

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publication date

1 September 2008

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14 January 2020

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14 January 2020

volume

27

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14 January 2020

page(s)

5443-5453

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14 January 2020

issue

41

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https://scigraph.springernature.com/pub.10.1038/onc.2008.241

14 January 2020

exact match

0 references

cites work

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease.

21 January 2018

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p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control

21 January 2018

1 reference

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PTEN enters the nuclear age.

21 January 2018

1 reference

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21 January 2018

TP53 and breast cancer

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https://api.crossref.org/works/10.1038%2FONC.2008.241

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN regulates Mdm2 expression through the P1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

21 January 2018

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Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

21 January 2018

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Membrane-binding and activation mechanism of PTEN.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.241

The multiple roles of PTEN in tumor suppression

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.241

Pten is essential for embryonic development and tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN: one gene, many syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN and inherited hamartoma-cancer syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Protein modules as organizers of membrane structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Loss of heterozygosity on chromosome 10 is more extensive in primary (de novo) than in secondary glioblastomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Profiling the downstream genes of tumor suppressor PTEN in lung cancer cells by complementary DNA microarray

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Identification of germline mutation of PTEN gene and analysis of apoptosis resistance of the lymphocytes in a patient with Cowden disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN modulates insulin-like growth factor II (IGF-II)-mediated signaling; the protein phosphatase activity of PTEN downregulates IGF-II expression in hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Cancer. p53, guardian of the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN function: how normal cells control it and tumour cells lose it

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

P53 is a tumor suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN enters the nucleus by diffusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Growth suppression by p16ink4 requires functional retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN induces G1 cell cycle arrest and inhibits MMP-9 expression via the regulation of NF-kappaB and AP-1 in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

The PTEN tumor suppressor is a negative modulator of androgen receptor transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN: a novel anti-oncogenic function independent of phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Human cancer, PTEN and the PI-3 kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Lack of PTEN sequesters CHK1 and initiates genetic instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Regulation of cell migration by the C2 domain of the tumor suppressor PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

The biology and clinical relevance of the PTEN tumor suppressor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Essential role for nuclear PTEN in maintaining chromosomal integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Regulation of p53 by Mdm2: fate is in the numbers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Life, death, and ubiquitin: taming the mule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN: life as a tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN: from pathology to biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Genomic integrity and the genetics of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Identification of a tumour suppressor network opposing nuclear Akt function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Ubiquitination regulates PTEN nuclear import and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Protean PTEN: form and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

p21 is a universal inhibitor of cyclin kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Different splicing defects lead to differential effects downstream of the lipid and protein phosphatase activities of PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

GI polyposis and glycogenic acanthosis of the esophagus associated with PTEN mutation positive Cowden syndrome in the absence of cutaneous manifestations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN Autoregulates Its Expression by Stabilization of p53 in a Phosphatase-Independent Manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

The relationship between microsatellite instability and PTEN gene mutations in endometrial cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Regulation of c-Met-dependent gene expression by PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

A role for nuclear PTEN in neuronal differentiation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN loss inhibits CHK1 to cause double stranded-DNA breaks in cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

The Li-Fraumeni syndrome: from clinical epidemiology to molecular genetics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

PTEN blocks insulin-mediated ETS-2 phosphorylation through MAP kinase, independently of the phosphoinositide 3-kinase pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.241

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.241

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18794879%20AND%20SRC:MED&resulttype=core&format=json

release_czzm2hchgra5llxx2xhy4ik5ey

14 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/czzm2hchgra5llxx2xhy4ik5ey

mapped directly with Wikidata item

24 November 2022

based on heuristic

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