Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD) (Q28568146)

A portrait of Alzheimer secretases--new features and familiar faces

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

The cell biology of Alzheimer's disease: uncovering the secrets of secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Notch signaling: from the outside in

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Mice lacking both presenilin genes exhibit early embryonic patterning defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Clearing the brain's amyloid cobwebs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Inhibition of insulin degradation by hepatoma cells after microinjection of monoclonal antibodies to a specific cytosolic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Thimet oligopeptidase and oligopeptidase M or neurolysin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Development and characterization of novel potent and stable inhibitors of endopeptidase EC 3.4.24.15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

An unusual active site identified in a family of zinc metalloendopeptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Metabolic regulation of brain Abeta by neprilysin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111571200

21 January 2018

Identifiers

DOI

10.1074/JBC.M111571200

1 reference

Consolidated OpenCitations Corpus – April 2017

4742121

4742121

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference