Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice (Q36087916)

12 August 2017

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice (English)

1 reference

12 August 2017

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29

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François-Xavier Cantrelle

12 August 2017

19

François-Xavier Cantrelle

0 references

Damien Bosc

Damien Bosc

3

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Nathalie Hennuyer

Nathalie Hennuyer

2

0 references

Julie Charton

Julie Charton

7

0 references

Rébecca F Déprez-Poulain

Rebecca Deprez-Poulain

1

0 references

Wei-Jen Tang

Wei-Jen Tang

27

0 references

Guy Lippens

Guy Lippens

25

0 references

Benoit Deprez

Benoit Deprez

30

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Peter M van Endert

Peter van Endert

28

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author name string

Wenguang G Liang

4

1 reference

12 August 2017

Emmanuelle Enée

5

1 reference

12 August 2017

Xavier Marechal

6

1 reference

12 August 2017

Jane Totobenazara

8

1 reference

12 August 2017

Gonzague Berte

9

1 reference

12 August 2017

Jouda Jahklal

10

1 reference

12 August 2017

Tristan Verdelet

11

1 reference

12 August 2017

Julie Dumont

12

1 reference

12 August 2017

Sandrine Dassonneville

13

1 reference

12 August 2017

Eloise Woitrain

14

1 reference

12 August 2017

Marion Gauriot

15

1 reference

12 August 2017

Charlotte Paquet

16

1 reference

12 August 2017

Isabelle Duplan

17

1 reference

12 August 2017

Paul Hermant

18

1 reference

12 August 2017

Emmanuel Sevin

20

1 reference

12 August 2017

Maxime Culot

21

1 reference

12 August 2017

Valerie Landry

22

1 reference

12 August 2017

Adrien Herledan

23

1 reference

12 August 2017

Catherine Piveteau

24

1 reference

12 August 2017

Florence Leroux

26

1 reference

12 August 2017

language of work or name

English

0 references

publication date

23 September 2015

1 reference

12 August 2017

Nature Communications

1 reference

12 August 2017

6

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12 August 2017

8250

1 reference

Creative Commons Attribution 4.0 International

12 August 2017

start time

23 September 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms9250

0 references

cites work

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

1 reference

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Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis

2 October 2017

1 reference

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Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

2 October 2017

1 reference

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Deletion of the fission yeast homologue of human insulinase reveals a TORC1-dependent pathway mediating resistance to proteotoxic stress

2 October 2017

1 reference

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Proteolytically inactive insulin-degrading enzyme inhibits amyloid formation yielding non-neurotoxic aβ peptide aggregates

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Deletion of insulin-degrading enzyme elicits antipodal, age-dependent effects on glucose and insulin tolerance

2 October 2017

1 reference

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Exploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulator

2 October 2017

1 reference

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Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin

2 October 2017

1 reference

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Kinetic target-guided synthesis

2 October 2017

1 reference

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

2 October 2017

1 reference

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Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-α, and Amylin by Human Insulin-Degrading Enzyme

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

2 October 2017

1 reference

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Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Stem cell antigen-1 localizes to lipid microdomains and associates with insulin degrading enzyme in skeletal myoblasts

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

The insulysin (insulin degrading enzyme) enigma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Coot: model-building tools for molecular graphics

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

The CCP4 molecular-graphics project

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Functional relevance of a novel SlyX motif in non-conventional secretion of insulin-degrading enzyme

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity.

11 July 2018

1 reference

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Hydroxamates: relationships between structure and plasma stability

23 September 2018

1 reference

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In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

In situ click chemistry: enzyme inhibitors made to their own specifications

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Endosomal proteolysis of glucagon at neutral pH generates the bioactive degradation product miniglucagon-(19-29).

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Absolute potassium cation affinities (PCAs) in the gas phase

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Insulin inhibition of the proteasome is dependent on degradation of insulin by insulin-degrading enzyme

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4580987

Processing of X-ray diffraction data collected in oscillation mode

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS9250

CRYSOL– a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS9250

Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26394692

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effect of insulinase-inhibitor on hypoglycemic action of insulin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26394692

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibitors of HIV-1 protease by using in situ click chemistry

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26394692

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS9250

1 reference

12 August 2017

0 references

1 reference

12 August 2017

1 reference