The ubiquitin-proteasome pathway and pathogenesis of human diseases (Q33540242)

27 July 2017

title

The ubiquitin-proteasome pathway and pathogenesis of human diseases (English)

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ubiquitin-proteasome system

27 July 2017

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2

Ciechanover A

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27 July 2017

Schwartz AL

1

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27 July 2017

publication date

1 January 1999

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Annual Review of Medicine

27 July 2017

language of work or name

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27 July 2017

volume

50

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27 July 2017

page(s)

57-74

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publication type of scholarly work

27 July 2017

review article

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Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

cites work

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Signal transduction through NF-kappa B.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Ubiquitination mediated by the Npi1p/Rsp5p ubiquitin-protein ligase is required for endocytosis of the yeast uracil permease

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Signal transduction through beta-catenin and specification of cell fate during embryogenesis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Structure of 20S proteasome from yeast at 2.4 A resolution

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Structure and functions of the 20S and 26S proteasomes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Degradation of the proto-oncogene product c-Fos by the ubiquitin proteolytic system in vivo and in vitro: identification and characterization of the conjugating enzymes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Selective protein degradation: a journey's end within the proteasome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Linkage of replication to start by the Cdk inhibitor Sic1.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

The 26S proteasome: subunits and functions

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Ubiquitin-dependent protein degradation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Make it or break it: the role of ubiquitin-dependent proteolysis in cellular regulation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Isolation, characterization, and partial purification of a novel ubiquitin-protein ligase, E3. Targeting of protein substrates via multiple and distinct recognition signals and conjugating enzymes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

The E6-Ap ubiquitin-protein ligase (UBE3A) gene is localized within a narrowed Angelman syndrome critical region

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Proteasomes: protein degradation machines of the cell

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Proteasome: from structure to function

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Degradation of CFTR by the ubiquitin-proteasome pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 Å resolution

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Protein translocation channels in the proteasome and other proteases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

UBE3A/E6-AP mutations cause Angelman syndrome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

A Function for Monoubiquitination in the Internalization of a G Protein–Coupled Receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Linkage of the ubiquitin-conjugating system and the endocytic pathway in ligand-induced internalization of the growth hormone receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

The linker region of the ABC-transporter Ste6 mediates ubiquitination and fast turnover of the protein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Cyclin is degraded by the ubiquitin pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Degradation of G alpha by the N-end rule pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Caspases: Intracellular Signaling by Proteolysis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

The ubiquitin-mediated proteolytic pathway: mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

The ubiquitin-proteasome proteolytic pathway

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

β-catenin is a target for the ubiquitin–proteasome pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

The ubiquitin-activating enzyme E1 is phosphorylated and localized to the nucleus in a cell cycle-dependent manner

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Structure of the proteasome activator REGα (PA28α)

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.MED.50.1.57

Identifiers

DOI

10.1146/ANNUREV.MED.50.1.57

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27 July 2017

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