The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis (Q45345755)

13 December 2017

The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis (English)

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13 December 2017

Ping Xie

1

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13 December 2017

Minghua Zhang

2

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13 December 2017

Shan He

3

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13 December 2017

Kefeng Lu

4

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13 December 2017

Yuhan Chen

5

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13 December 2017

Guichun Xing

6

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13 December 2017

Yiming Lu

7

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13 December 2017

Ping Liu

8

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13 December 2017

Yang Li

9

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13 December 2017

Shaoxia Wang

10

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13 December 2017

Nan Chai

11

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13 December 2017

Jiawei Wu

12

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13 December 2017

Haiteng Deng

13

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13 December 2017

Hong-Rui Wang

14

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13 December 2017

Yu Cao

15

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13 December 2017

Fei Zhao

16

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13 December 2017

Yu Cui

17

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13 December 2017

Jian Wang

18

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13 December 2017

Fuchu He

19

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13 December 2017

Lingqiang Zhang

20

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13 December 2017

language of work or name

English

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publication date

13 May 2014

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13 December 2017

Nature Communications

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13 December 2017

5

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13 December 2017

3733

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https://scigraph.springernature.com/pub.10.1038/ncomms4733

13 December 2017

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cites work

RING domain E3 ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Physiological functions of the HECT family of ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

NEDDylation regulates E2F-1-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Neddylation positively regulates the ubiquitin E3 ligase activity of parkin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Ribosomal proteins are targets for the NEDD8 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

The NED-8 conjugating system in Caenorhabditis elegans is required for embryogenesis and terminal differentiation of the hypodermis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Control of cell proliferation via elevated NEDD8 conjugation in oral squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

A Dual E3 Mechanism for Rub1 Ligation to Cdc53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Regulation of planar cell polarity by Smurf ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Image-based genome-wide siRNA screen identifies selective autophagy factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Ubiquitin-binding domains - from structures to functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Nedd8-modification of Cul1 is promoted by Roc1 as a Nedd8-E3 ligase and regulates its stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Regulation of cell polarity and protrusion formation by targeting RhoA for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

NEDD8 recruits E2-ubiquitin to SCF E3 ligase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Direct binding to Rsp5 mediates ubiquitin-independent sorting of Sna3 via the multivesicular body pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Overexpression of Sna3 stabilizes tryptophan permease Tat2, potentially competing for the WW domain of Rsp5 ubiquitin ligase with its binding protein Bul1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Interaction of NUB1 with the proteasome subunit S5a.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

The NEDD8-activating enzyme inhibitor, MLN4924, cooperates with TRAIL to augment apoptosis through facilitating c-FLIP degradation in head and neck cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

A novel protein modification pathway related to the ubiquitin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4733

21 January 2018

Identifiers

DOI

10.1038/NCOMMS4733

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Dimensions Publication ID

13 December 2017

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