Physiological functions of the HECT family of ubiquitin ligases (Q29617293)

Europe PubMed Central

title

Physiological functions of the HECT family of ubiquitin ligases (English)

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30 April 2017

author name string

Rotin D

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1

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30 April 2017

Kumar S

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2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19436320

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language of work or name

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30 April 2017

publication date

June 2009

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Nature Reviews Molecular Cell Biology

30 April 2017

published in

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30 April 2017

volume

10

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30 April 2017

page(s)

398-409

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issue

6

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30 April 2017

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Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

31 March 2020

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Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling

31 March 2020

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A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

31 March 2020

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Identification of a set of genes with developmentally down-regulated expression in the mouse brain

31 March 2020

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Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb

31 March 2020

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The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo

31 March 2020

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mGrb10 interacts with Nedd4

31 March 2020

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Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain

31 March 2020

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WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome

31 March 2020

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Solution structure of a Nedd4 WW domain-ENaC peptide complex

31 March 2020

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The HERC proteins: functional and evolutionary insights.

31 March 2020

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Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)

31 March 2020

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Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

31 March 2020

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Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase

31 March 2020

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Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain

31 March 2020

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Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis

31 March 2020

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Molecular determinants of polyubiquitin linkage selection by an HECT ubiquitin ligase

31 March 2020

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A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae

31 March 2020

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The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase

31 March 2020

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Communication between Distant Sites in RNA Polymerase II through Ubiquitylation Factors and the Polymerase CTD

31 March 2020

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Ubiquitin and endocytic internalization in yeast and animal cells.

31 March 2020

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Versatile role of the yeast ubiquitin ligase Rsp5p in intracellular trafficking

31 March 2020

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Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease

31 March 2020

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Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein

31 March 2020

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Monoubiquitin carries a novel internalization signal that is appended to activated receptors

31 March 2020

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A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis

31 March 2020

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Nucleotide excision repair and the degradation of RNA pol II by the Caenorhabditis elegans XPA and Rsp5 orthologues, RAD-3 and WWP-1.

31 March 2020

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LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans

31 March 2020

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Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster

31 March 2020

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Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

31 March 2020

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Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins

31 March 2020

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The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis.

31 March 2020

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dSmurf Selectively Degrades Decapentaplegic-activated MAD, and Its Overexpression Disrupts Imaginal Disc Development

31 March 2020

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Nedd4 controls animal growth by regulating IGF-1 signaling

31 March 2020

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The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

31 March 2020

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The logic of TGFbeta signaling.

31 March 2020

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A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

31 March 2020

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Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation

31 March 2020

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Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

31 March 2020

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Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

31 March 2020

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Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

31 March 2020

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

31 March 2020

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TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

31 March 2020

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Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

31 March 2020

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The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

31 March 2020

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The ubiquitin-protein ligase Itch regulates p73 stability

31 March 2020

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The E3 ubiquitin ligase Itch controls the protein stability of p63

31 March 2020

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A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel

31 March 2020

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The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel

31 March 2020

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The PY motif of ENaC, mutated in Liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool

31 March 2020

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Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination

31 March 2020

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ESCRTing proteins in the endocytic pathway

31 March 2020

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31 March 2020

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ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity

31 March 2020

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ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response

31 March 2020

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NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

31 March 2020

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Ubiquitination regulates PTEN nuclear import and tumor suppression

31 March 2020

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Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells

31 March 2020

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The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

31 March 2020

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Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

31 March 2020

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Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation

31 March 2020

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Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

31 March 2020

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Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer

31 March 2020

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The amplified WWP1 gene is a potential molecular target in breast cancer

31 March 2020

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Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells

31 March 2020

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Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1

31 March 2020

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Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2

31 March 2020

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Molecular mechanisms of human hypertension

31 March 2020

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Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2

31 March 2020

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A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity

31 March 2020

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A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner

31 March 2020

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NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1.

31 March 2020

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Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins

31 March 2020

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TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.

31 March 2020

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A very large protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice.

31 March 2020

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A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color

31 March 2020

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Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression

31 March 2020

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Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B

31 March 2020

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HERC3 binding to and regulation by ubiquitin

31 March 2020

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Disruption of the ubiquitin ligase HERC4 causes defects in spermatozoon maturation and impaired fertility

31 March 2020

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HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells

31 March 2020

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Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells

31 March 2020

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HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets

31 March 2020

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Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2

31 March 2020

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EDD mediates DNA damage-induced activation of CHK2

31 March 2020

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Putative tumor suppressor EDD interacts with and up-regulates APC

31 March 2020

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Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion

31 March 2020

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ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

31 March 2020

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

31 March 2020

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The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

31 March 2020

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The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein

31 March 2020

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Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

31 March 2020

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HECT E3s and human disease

31 March 2020

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Submicroscopic duplications of the hydroxysteroid dehydrogenase HSD17B10 and the E3 ubiquitin ligase HUWE1 are associated with mental retardation

31 March 2020

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Imprinting of the Angelman syndrome gene, UBE3A, is restricted to brain.

31 March 2020

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The Angelman syndrome candidate gene, UBE3A/E6-AP, is imprinted in brain.

31 March 2020

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UBE3A/E6-AP mutations cause Angelman syndrome

31 March 2020

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Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.

31 March 2020

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Sleep disturbances in Ube3a maternal-deficient mice modeling Angelman syndrome.

31 March 2020

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A Drosophila model for Angelman syndrome

31 March 2020

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The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

31 March 2020

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Studies of l(3)c43hs1 a polyphasic, temperature-sensitive mutant of Drosophila melanogaster with a variety of imaginal disc defects

31 March 2020

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The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms

31 March 2020

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EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer

31 March 2020

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Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma

31 March 2020

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Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney

31 March 2020

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The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers

31 March 2020

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The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure

31 March 2020

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Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.

31 March 2020

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G2E3 is a dual function ubiquitin ligase required for early embryonic development

31 March 2020

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Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression

31 March 2020

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Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel

31 March 2020

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The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch

31 March 2020

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Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

31 March 2020

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Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain

31 March 2020

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Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1

31 March 2020

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Numb antagonizes Notch signaling to specify sibling neuron cell fates

31 March 2020

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Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

31 March 2020

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The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme

31 March 2020

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Post-translation control of Nramp metal transport in yeast. Role of metal ions and the BSD2 gene

31 March 2020

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Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins.

31 March 2020

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Negative control of heavy metal uptake by the Saccharomyces cerevisiae BSD2 gene

31 March 2020

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Transferrin receptor-like proteins control the degradation of a yeast metal transporter

31 March 2020

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Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins

31 March 2020

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Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation

31 March 2020

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Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins

31 March 2020

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Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1.

31 March 2020

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31 March 2020

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Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodies

31 March 2020

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Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast

31 March 2020

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Global protein stability profiling in mammalian cells

31 March 2020

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Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

31 March 2020

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Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

31 March 2020

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Aberrant methylation of the HACE1 gene is frequently detected in advanced colorectal cancer.

31 March 2020

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12 December 2020

A mouse model for Liddle's syndrome

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12 December 2020

Pub1 acts as an E6-AP-like protein ubiquitiin ligase in the degradation of cdc25.

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12 December 2020

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

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12 December 2020

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Consolidated OpenCitations Corpus – April 2017

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1312710

1033017251

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1312710

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19436320

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30 April 2017

Consolidated OpenCitations Corpus – April 2017