Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases (Q45345757)

13 December 2017

Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases (English)

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13 December 2017

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Elena Santonico

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Gianni Cesareni

10

object named as

Gianni Cesareni

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13 December 2017

Shlomo Oved

1

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13 December 2017

Yaron Mosesson

2

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13 December 2017

Yaara Zwang

3

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13 December 2017

Keren Shtiegman

5

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13 December 2017

Mina D Marmor

6

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13 December 2017

Bose S Kochupurakkal

7

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13 December 2017

Menachem Katz

8

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13 December 2017

Sara Lavi

9

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13 December 2017

Yosef Yarden

11

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13 December 2017

language of work or name

English

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publication date

30 May 2006

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Journal of Biological Chemistry

13 December 2017

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13 December 2017

281

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13 December 2017

21640-21651

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13 December 2017

31

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Negative receptor signalling

13 December 2017

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513034200

Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

When ubiquitin meets ubiquitin receptors: a signalling connection

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

Evolution and function of ubiquitin-like protein-conjugation systems

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

A new NEDD8-ligating system for cullin-4A

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

Nedd8-modification of Cul1 is promoted by Roc1 as a Nedd8-E3 ligase and regulates its stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513034200

Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1).

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

Nedd8 on cullin: building an expressway to protein destruction.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513034200

Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

Stable suppression of tumorigenicity by virus-mediated RNA interference

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

Endocytosis of functional epidermal growth factor receptor-green fluorescent protein chimera

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513034200

A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513034200

The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513034200

Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513034200

Multiple roles for Rsp5p-dependent ubiquitination at the internalization step of endocytosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513034200

Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

A novel protein modification pathway related to the ubiquitin system

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513034200

The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513034200

Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513034200

The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513034200

21 January 2018

Identifiers

DOI

10.1074/JBC.M513034200

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13 December 2017

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