Neddylation positively regulates the ubiquitin E3 ligase activity of parkin. (Q48695224)

14 February 2018

title

Neddylation positively regulates the ubiquitin E3 ligase activity of parkin. (English)

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14 February 2018

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4

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author name string

Ji Won Um

1

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14 February 2018

Kyung Ah Han

2

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14 February 2018

Eunju Im

3

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14 February 2018

Kyule Lee

5

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14 February 2018

Kwang Chul Chung

6

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14 February 2018

publication date

24 January 2012

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14 February 2018

Journal of Neuroscience Research

published in

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volume

90

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issue

5

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page(s)

1030-1042

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14 February 2018

Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.

cites work

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Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline.

21 January 2018

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Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

1 reference

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

21 January 2018

1 reference

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

21 January 2018

1 reference

NEDD8 protein is involved in ubiquitinated inclusion bodies

21 January 2018

1 reference

Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway

21 January 2018

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Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

21 January 2018

1 reference

Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults

21 January 2018

1 reference

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

1 reference

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

1 reference

BAG5 inhibits parkin and enhances dopaminergic neuron degeneration

21 January 2018

1 reference

Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein

21 January 2018

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NEDD8 recruits E2-ubiquitin to SCF E3 ligase.

21 January 2018

1 reference

Role of ubiquitin- and Ubl-binding proteins in cell signaling

21 January 2018

1 reference

Parkinson's disease. Second of two parts

21 January 2018

1 reference

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination

21 January 2018

1 reference

NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases

21 January 2018

1 reference

Parkin: a multifaceted ubiquitin ligase.

21 January 2018

1 reference

Lewy-body formation is an aggresome-related process: a hypothesis

21 January 2018

1 reference

Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases

21 January 2018

1 reference

Nedd8 on cullin: building an expressway to protein destruction.

21 January 2018

1 reference

Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series

21 January 2018

1 reference

Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

21 January 2018

1 reference

Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity.

21 January 2018

1 reference

14-3-3eta is a novel regulator of parkin ubiquitin ligase

21 January 2018

1 reference

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

21 January 2018

1 reference

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

1 reference

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

1 reference

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

21 January 2018

1 reference

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

21 January 2018

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Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.

21 January 2018

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Functional modulation of parkin through physical interaction with SUMO-1.

21 January 2018

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Parkin ubiquitinates and promotes the degradation of RanBP2

21 January 2018

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Molecular interaction between parkin and PINK1 in mammalian neuronal cells

21 January 2018

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Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease

21 January 2018

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Ubiquitin and ubiquitin-like modifications of the p53 family

21 January 2018

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Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function

21 January 2018

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Protection of cullin-RING E3 ligases by CSN-UBP12.

21 January 2018

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Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization

21 January 2018

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Novel substrates and functions for the ubiquitin-like molecule NEDD8.

21 January 2018

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Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

21 January 2018

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Ribosomal proteins are targets for the NEDD8 pathway

21 January 2018

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Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity

21 January 2018

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Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

21 January 2018

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JNR.22828

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14 February 2018

release_zogcb2yu2rafdhqqyr73t6qxhm

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zogcb2yu2rafdhqqyr73t6qxhm

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

22271254

1 reference

14 February 2018