NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL (Q24321579)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18323857%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

title

NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL (English)

1 reference

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3 January 2020

1

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3 January 2020

author name string

Michael Ohh

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18323857%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

language of work or name

English

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publication date

7 March 2008

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18323857%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18323857%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

volume

9

1 reference

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3 January 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18323857%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

page(s)

486-491

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Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans

3 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

Molecular basis of the VHL hereditary cancer syndrome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

pVHL function is essential for endothelial extracellular matrix deposition.

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

Beyond the hypoxia-inducible factor-centric tumour suppressor model of von Hippel-Lindau

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

Role of the NEDD8 modification of Cul2 in the sequential activation of ECV complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

Nedd8 on cullin: building an expressway to protein destruction.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

Dissociation of fibronectin from gelatin-agarose by amino compounds

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373363

Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOR.2008.19

Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOR.2008.19

Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFkappaB-dependent transcription

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18323857

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18323857

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOR.2008.19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18323857%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18323857%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

PubMed publication ID

18323857

1 reference