Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo (Q39496098)

12 September 2017

Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo (English)

1 reference

Probing biomolecular interactions by combining ETD-tandem mass spectrometry with chemical footprinting methodologies

12 September 2017

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26 April 2019

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26

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12 September 2017

22

Neil A Ranson

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Alison E. Ashcroft

23

Alison E Ashcroft

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Clare L Pashley

Clare L Pashley

20

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Matthew G Iadanza

Matthew G Iadanza

21

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Jonathan J Phillips

Jonathan J Phillips

3

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Theodoros Karamanos

19

Theodoros K Karamanos

1 reference

12 September 2017

Claire L Dobson

1

1 reference

12 September 2017

Paul W A Devine

2

1 reference

12 September 2017

Daniel R Higazi

4

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12 September 2017

Christopher Lloyd

5

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12 September 2017

Bojana Popovic

6

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12 September 2017

Joanne Arnold

7

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12 September 2017

Andrew Buchanan

8

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12 September 2017

Arthur Lewis

9

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12 September 2017

Joanne Goodman

10

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12 September 2017

Christopher F van der Walle

11

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12 September 2017

Peter Thornton

12

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12 September 2017

Lisa Vinall

13

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12 September 2017

David Lowne

14

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12 September 2017

Anna Aagaard

15

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12 September 2017

Lise-Lotte Olsson

16

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12 September 2017

Anna Ridderstad Wollberg

17

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12 September 2017

Fraser Welsh

18

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12 September 2017

Alistair D Kippen

24

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12 September 2017

Tristan J Vaughan

25

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12 September 2017

David C Lowe

27

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12 September 2017

language of work or name

English

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publication date

20 December 2016

1 reference

full work available at URL

12 September 2017

http://eprints.whiterose.ac.uk/110030/

content deliverer

White Rose Research Online

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published in

Scientific Reports

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12 September 2017

6

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12 September 2017

38644

1 reference

https://scigraph.springernature.com/pub.10.1038/srep38644

12 September 2017

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cites work

Antibodies to watch in 2016.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

A novel screening method to assess developability of antibody-like molecules

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Boosting antibody developability through rational sequence optimization

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

In silico selection of therapeutic antibodies for development: viscosity, clearance, and chemical stability

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Remediating agitation-induced antibody aggregation by eradicating exposed hydrophobic motifs

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Analytical approaches for size and mass analysis of large protein assemblies.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Therapeutic protein aggregation: mechanisms, design, and control

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Freezing-induced perturbation of tertiary structure of a monoclonal antibody

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

A high-yielding CHO transient system: coexpression of genes encoding EBNA-1 and GS enhances transient protein expression

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: a FACS-based, high-throughput selection and analytical tool

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Immunogenicity of therapeutic proteins: influence of aggregation

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Advances in ion mobility spectrometry-mass spectrometry reveal key insights into amyloid assembly

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: what have we learned?

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Mechanisms of protein aggregation

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Phasercrystallographic software

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Stepwise evolution of protein native structure with electrospray into the gas phase, 10(-12) to 10(2) s

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Nature and consequences of protein-protein interactions in high protein concentration solutions

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Protein aggregation and bioprocessing

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Effects of protein aggregates: an immunologic perspective

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Affinity maturation of phage display antibody populations using ribosome display

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Hydrogen exchange mass spectrometry for the analysis of protein dynamics

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Protein aggregation and its inhibition in biopharmaceutics

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Coot: model-building tools for molecular graphics

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Refinement of macromolecular structures by the maximum-likelihood method

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony‐stimulating factor

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Use of TLS parameters to model anisotropic displacements in macromolecular refinement

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Three-dimensional structure of a human Fab with high affinity for tetanus toxoid

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

An integrated vector system for the eukaryotic expression of antibodies or their fragments after selection from phage display libraries

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Nerve growth factor in different crystal forms displays structural flexibility and reveals zinc binding sites

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Whole-molecule antibody engineering: generation of a high-affinity anti-IL-6 antibody with extended pharmacokinetics

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Identical V region amino acid sequences and segments of sequences in antibodies of different specificities. Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Aggregation risk prediction for antibodies and its application to biotherapeutic development

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

A strategy for risk mitigation of antibodies with fast clearance.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Complex pharmacokinetics of a humanized antibody against human amyloid beta peptide, anti-abeta Ab2, in nonclinical species.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Structure-based engineering of a monoclonal antibody for improved solubility

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Reduced elimination of IgG antibodies by engineering the variable region.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Mechanically-induced aggregation of the monoclonal antibody cetuximab

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Aggregation-prone motifs in human immunoglobulin G.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Off-target activity of TNF-alpha inhibitors characterized by protein biochips

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Conformational dynamics of the molecular chaperone Hsp90 in complexes with a co-chaperone and anticancer drugs.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Studying noncovalent protein complexes by electrospray ionization mass spectrometry

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5171805

Cross-interaction chromatography: a rapid method to identify highly soluble monoclonal antibody candidates

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27995962

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SREP38644

1 reference

Dimensions Publication ID

12 September 2017

0 references

0 references

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1 reference

12 September 2017

1 reference