Boosting antibody developability through rational sequence optimization (Q27311159)

26 June 2017

Boosting antibody developability through rational sequence optimization (English)

1 reference

26 June 2017

1 reference

Daniel Seeliger

1

1 reference

26 June 2017

Patrick Schulz

2

1 reference

26 June 2017

Tobias Litzenburger

3

1 reference

26 June 2017

Julia Spitz

4

1 reference

26 June 2017

Stefan Hoerer

5

1 reference

26 June 2017

Michaela Blech

6

1 reference

26 June 2017

Barbara Enenkel

7

1 reference

26 June 2017

Joey M Studts

8

1 reference

26 June 2017

Patrick Garidel

9

1 reference

26 June 2017

Anne R Karow

10

1 reference

26 June 2017

language of work or name

English

0 references

publication date

1 January 2015

1 reference

26 June 2017

Monoclonal Antibodies

1 reference

26 June 2017

7

1 reference

26 June 2017

505-515

1 reference

26 June 2017

3

1 reference

MolProbity: all-atom structure validation for macromolecular crystallography

26 June 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Mechanisms of tryptophan fluorescence shifts in proteins

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Features and development of Coot

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Phasercrystallographic software

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Scaling and assessment of data quality

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Data processing and analysis with the autoPROC toolbox

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Can the pharmaceutical industry reduce attrition rates?

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

ElNemo: a normal mode web server for protein movement analysis and the generation of templates for molecular replacement

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Therapeutic protein aggregation: mechanisms, design, and control

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Characterization and screening of IgG binding to the neonatal Fc receptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Observation of small cluster formation in concentrated monoclonal antibody solutions and its implications to solution viscosity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Conformational stability as a design target to control protein aggregation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

High throughput prediction of the long-term stability of pharmaceutical macromolecules from short-term multi-instrument spectroscopic data

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Development of scoring functions for antibody sequence assessment and optimization

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

A critical evaluation of microcalorimetry as a predictive tool for long term stability of liquid protein formulations: granulocyte colony stimulating factor (GCSF).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Coarse-grained modeling of the self-association of therapeutic monoclonal antibodies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Role of conformational sampling in computing mutation-induced changes in protein structure and stability

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Protein thermostability calculations using alchemical free energy simulations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Protein aggregation--pathways and influencing factors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Amyloidogenic determinants are usually not buried

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Design of therapeutic proteins with enhanced stability.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Principles, approaches, and challenges for predicting protein aggregation rates and shelf life

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Protein aggregation and bioprocessing

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Process economics of industrial monoclonal antibody manufacture

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Prediction of aggregation rate and aggregation-prone segments in polypeptide sequences

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Challenges in the development of high protein concentration formulations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

A comparative study of motor-protein motions by using a simple elastic-network model

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

A simple model for proteins with interacting domains. Applications to scanning calorimetry data

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Antibodies to watch in 2014.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

An unfolded CH1 domain controls the assembly and secretion of IgG antibodies.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622947

Structure-based engineering of a monoclonal antibody for improved solubility

31 May 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2015.1017695

Geometry-based sampling of conformational transitions in proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2015.1017695

Prediction of protein-protein interaction sites using patch analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2015.1017695

The PASTA server for protein aggregation prediction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2015.1017695

Prediction of aggregation-prone regions in structured proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2015.1017695

A rapid, sensitive and economical assessment of monoclonal antibody conformational stability by intrinsic tryptophan fluorescence spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2015.1017695

A broad range of Fab stabilities within a host of therapeutic IgGs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2015.1017695

Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2015.1017695

Domain interactions in the Fab fragment: a comparative evaluation of the single-chain Fv and Fab format engineered with variable domains of different stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2015.1017695

Predicting accelerated aggregation rates for monoclonal antibody formulations, and challenges for low-temperature predictions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2015.1017695

Dissociation and denaturation equilibria and kinetics of a homogeneous human immunoglobulin Fab fragment

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25759214

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Fluorescence and the location of tryptophan residues in protein molecules

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25759214

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The IgG Fc contains distinct Fc receptor (FcR) binding sites: the leukocyte receptors Fc gamma RI and Fc gamma RIIa bind to a region in the Fc distinct from that recognized by neonatal FcR and protein A

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25759214

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1080/19420862.2015.1017695

1 reference

OpenCitations bibliographic resource ID

26 June 2017

4614037

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference