Structure-based engineering of a monoclonal antibody for improved solubility (Q44381771)

2 December 2017

Structure-based engineering of a monoclonal antibody for improved solubility (English)

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2 December 2017

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12

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2 December 2017

Sheng-Jiun Wu

1

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2 December 2017

Jinquan Luo

2

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2 December 2017

Karyn T O'Neil

3

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2 December 2017

James Kang

4

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2 December 2017

Eilyn R Lacy

5

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2 December 2017

Gabriela Canziani

6

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2 December 2017

Audrey Baker

7

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2 December 2017

Maggie Huang

8

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2 December 2017

Qing Mike Tang

9

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2 December 2017

T Shantha Raju

10

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2 December 2017

Steven A Jacobs

11

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2 December 2017

Gary L Gilliland

13

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2 December 2017

Yiqing Feng

14

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2 December 2017

11 June 2010

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Protein Engineering Design and Selection

2 December 2017

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2 December 2017

23

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2 December 2017

643-651

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2 December 2017

8

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Correlation for the partition behavior of proteins in aqueous two-phase systems: effect of surface hydrophobicity and charge

2 December 2017

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Natively unfolded protein stability as a coil-to-globule transition in charge/hydropathy space.

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Repertoires of aggregation-resistant human antibody domains

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

The protein as a variable in protein crystallization

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Characterization of protein aggregation: the case of a therapeutic immunoglobulin.

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

The use of recombinant methods and molecular engineering in protein crystallization

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Development of mammalian production cell lines expressing CNTO736, a glucagon like peptide-1-MIMETIBODY: factors that influence productivity and product quality

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Biophysical properties of human antibody variable domains

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Engineering aggregation-resistant proteins by directed evolution

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Thermodynamically stable aggregation-resistant antibody domains through directed evolution

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

A broad range of Fab stabilities within a host of therapeutic IgGs.

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

VHH, bivalent domains and chimeric Heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI'.

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Pharmaceutical profiling in drug discovery.

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

IMGT, the international ImMunoGeneTics information system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Optimization of humanized IgGs in glycoengineered Pichia pastoris.

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

New approaches for predicting protein retention time in hydrophobic interaction chromatography

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Antibody-antigen interactions: contact analysis and binding site topography.

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Structure-based substitutions for increased solubility of a designed protein

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Solubility engineering and crystallization of human apolipoprotein D.

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Anti-inflammatory actions of intravenous immunoglobulin

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Structural characterization of N-linked oligosaccharides on monoclonal antibody cetuximab by the combination of orthogonal matrix-assisted laser desorption/ionization hybrid quadrupole-quadrupole time-of-flight tandem mass spectrometry and sequentia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Fc glycans terminated with N-acetylglucosamine residues increase antibody resistance to papain

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Incremental window-based protein sequence alignment algorithms.

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Oligosaccharide analysis and molecular modeling of soluble forms of glycoproteins belonging to the Ly-6, scavenger receptor, and immunoglobulin superfamilies expressed in Chinese hamster ovary cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Higher levels of sialylated Fc glycans in immunoglobulin G molecules can adversely impact functionality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

High-resolution crystal structure of M-protease: phylogeny aided analysis of the high-alkaline adaptation mechanism

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Glycoengineering: the effect of glycosylation on the properties of therapeutic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Expression and characterization of a human BMP-7 variant with improved biochemical properties

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Engineering the isoelectric point of a renal cell carcinoma targeting antibody greatly enhances scFv solubility

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Epitope mapping of anti-interleukin-13 neutralizing antibody CNTO607

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Amino acid contribution to protein solubility: Asp, Glu, and Ser contribute more favorably than the other hydrophilic amino acids in RNase Sa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Membrane separations in biotechnology

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

The impact of PEGylation on biological therapies

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

Glycosylation of a VH residue of a monoclonal antibody against alpha (1----6) dextran increases its affinity for antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZQ037

21 January 2018

Identifiers

DOI

10.1093/PROTEIN/GZQ037

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2 December 2017

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