Remediating agitation-induced antibody aggregation by eradicating exposed hydrophobic motifs (Q36213460)

12 August 2017

Remediating agitation-induced antibody aggregation by eradicating exposed hydrophobic motifs (English)

1 reference

12 August 2017

Rutilio H Clark

1

1 reference

12 August 2017

Ramil F Latypov

2

1 reference

12 August 2017

Cyr De Imus

3

1 reference

12 August 2017

Jane Carter

4

1 reference

12 August 2017

Zien Wilson

5

1 reference

12 August 2017

Kathy Manchulenko

6

1 reference

12 August 2017

Michael E Brown

7

1 reference

12 August 2017

Randal R Ketchem

8

1 reference

12 August 2017

1 January 2014

1 reference

12 August 2017

Monoclonal Antibodies

1 reference

12 August 2017

6

1 reference

12 August 2017

6

1 reference

12 August 2017

1540-1550

1 reference

Transfer of engineered biophysical properties between different antibody formats and expression systems

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Aggregation in protein-based biotherapeutics: computational studies and tools to identify aggregation-prone regions

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Aggregates in monoclonal antibody manufacturing processes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Investigation of degradation processes in IgG1 monoclonal antibodies by limited proteolysis coupled with weak cation-exchange HPLC.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Design of therapeutic proteins with enhanced stability.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Transient expression and purification of chimeric heavy chain antibodies

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Monoclonal antibody "gold rush".

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Protein aggregation and bioprocessing

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Structure-immunogenicity relationships of therapeutic proteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Folding proteins in fatal ways

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Forces contributing to the conformational stability of proteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

The effects of excipients on protein aggregation during agitation: an interfacial shear rheology study

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Engineering a therapeutic IgG molecule to address cysteinylation, aggregation and enhance thermal stability and expression

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

The use of native cation-exchange chromatography to study aggregation and phase separation of monoclonal antibodies

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Relationship between thermal stability, degradation rate and expression yield of barnase variants in the periplasm of Escherichia coli.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Nondenaturing size-exclusion chromatography-mass spectrometry to measure stress-induced aggregation in a complex mixture of monoclonal antibodies

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Computational identification of antigen-binding antibody fragments

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Comprehensive analysis of surface charged residues involved in thermal stability in Alicyclobacillus acidocaldarius esterase 2.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Acid-induced aggregation of human monoclonal IgG1 and IgG2: molecular mechanism and the effect of solution composition.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Silicone oil- and agitation-induced aggregation of a monoclonal antibody in aqueous solution

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Inverse relationship of protein concentration and aggregation.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622659

Engineering protein stability

22 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.4161%2FMABS.36252

Yet Another Numbering Scheme for Immunoglobulin Variable Domains: An Automatic Modeling and Analysis Tool

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.4161%2FMABS.36252

Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions

21 January 2018

1 reference

12 December 2020

Development of hydrophobicity parameters to analyze proteins which bear post- or cotranslational modifications

1 reference

12 December 2020

Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors

1 reference

12 December 2020

Native and Hydrophobically Modified Human Immunoglobulin G at the Air/Water Interface

1 reference

12 December 2020

Opposite effects of polyols on antibody aggregation: thermal versus mechanical stresses

1 reference

12 December 2020

Identifiers

DOI

10.4161/MABS.36252

1 reference

12 August 2017

1 reference

12 August 2017

1 reference