Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics. (Q35616449)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25918417%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics (English)

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6 March 2020

1 reference

7

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6 March 2020

author name string

Angela Schoch

1

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6 March 2020

Hubert Kettenberger

2

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6 March 2020

Olaf Mundigl

3

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6 March 2020

Gerhard Winter

4

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6 March 2020

Julia Engert

5

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6 March 2020

Julia Heinrich

6

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6 March 2020

language of work or name

English

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publication date

27 April 2015

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Proceedings of the National Academy of Sciences of the United States of America

6 March 2020

published in

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6 March 2020

volume

112

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6 March 2020

page(s)

5997-6002

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6 March 2020

issue

19

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Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies

6 March 2020

cites work

1 reference

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Effects of charge on antibody tissue distribution and pharmacokinetics.

12 July 2018

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12 July 2018

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12 July 2018

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Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumab

12 July 2018

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The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity

12 July 2018

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Analyses of the recycling receptor, FcRn, in live cells reveal novel pathways for lysosomal delivery.

12 July 2018

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Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice

12 July 2018

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Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cells

12 July 2018

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Dependence of antibody-mediated presentation of antigen on FcRn

12 July 2018

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Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism

12 July 2018

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FcRn: the neonatal Fc receptor comes of age.

12 July 2018

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Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy

12 July 2018

1 reference

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From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling.

12 July 2018

1 reference

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Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level

12 July 2018

1 reference

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Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn.

12 July 2018

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The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan

12 July 2018

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Insulin-regulated release from the endosomal recycling compartment is regulated by budding of specialized vesicles

12 July 2018

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A review of modifications to recombinant antibodies: attempt to increase efficacy in oncology applications

12 July 2018

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Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding

12 July 2018

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Multiple roles for the major histocompatibility complex class I- related receptor FcRn

12 July 2018

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Stoichiometry of the interaction between the major histocompatibility complex-related Fc receptor and its Fc ligand

12 July 2018

1 reference

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The covalent structure of an entire gammaG immunoglobulin molecule

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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pH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat

12 July 2018

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Reduced elimination of IgG antibodies by engineering the variable region.

12 July 2018

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Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR.

25 September 2018

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25 September 2018

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Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

25 September 2018

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Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.

25 September 2018

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Pharmacokinetic characteristics and biodistribution of radioiodinated chimeric TNT-1, -2, and -3 monoclonal antibodies after chemical modification with biotin

25 September 2018

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Identifying amino acid residues that influence plasma clearance of murine IgG1 fragments by site-directed mutagenesis.

25 September 2018

1 reference

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The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs

25 September 2018

1 reference

12 December 2020

Crystallization and stoichiometry of binding of a complex between a rat intestinal Fc receptor and Fc

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12 December 2020

Population pharmacokinetic modeling of ustekinumab, a human monoclonal antibody targeting IL-12/23p40, in patients with moderate to severe plaque psoriasis

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12 December 2020

Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates

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12 December 2020

Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies

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12 December 2020

Monoclonal antibodies with identical Fc sequences can bind to FcRn differentially with pharmacokinetic consequences

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1408766112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25918417%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25918417%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25918417%20AND%20SRC:MED&resulttype=core&format=json