Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4. (Q35556797)

8 August 2017

Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4. (English)

1 reference

8 August 2017

1 reference

Daniela Bumbaca

1

1 reference

8 August 2017

Anne Wong

2

1 reference

8 August 2017

Elizabeth Drake

3

1 reference

8 August 2017

Arthur E Reyes

4

1 reference

8 August 2017

Benjamin C Lin

5

1 reference

8 August 2017

Jean-Philippe Stephan

6

1 reference

8 August 2017

Luc Desnoyers

7

1 reference

8 August 2017

Ben-Quan Shen

8

1 reference

8 August 2017

Mark S Dennis

9

1 reference

8 August 2017

1 July 2011

1 reference

8 August 2017

Monoclonal Antibodies

1 reference

8 August 2017

3

1 reference

8 August 2017

376-386

1 reference

8 August 2017

4

1 reference

Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models

8 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Role of Antibody Paratope Conformational Flexibility in the Manifestation of Molecular Mimicry

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Molecular evolution of affinity and flexibility in the immune system

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

The central role of the alternative complement pathway in human disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Molecular basis for the binding polyspecificity of an anti-cholera toxin peptide 3 monoclonal antibody

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Antibody engineering for the development of therapeutic antibodies

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Complement amplification revisited

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Polyreactivity of antibody molecules

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Antibody multispecificity mediated by conformational diversity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Test of a statistical model for molecular recognition in biological repertoires

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Continual low-level activation of the classical complement pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Structure and biology of complement protein C3, a connecting link between innate and acquired immunity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Tissue microarray technology for high-throughput molecular profiling of cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

UPA, a universal protein array system for quantitative detection of protein-protein, protein-DNA, protein-RNA and protein-ligand interactions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Molecular basis for the binding promiscuity of an anti-p24 (HIV-1) monoclonal antibody

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Antibody-antigen interactions: contact analysis and binding site topography.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Light-directed, spatially addressable parallel chemical synthesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Rapid characterization of binding specificity and cross-reactivity of antibodies using recombinant human protein arrays.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Exploring the energy landscape of antibody-antigen complexes: protein dynamics, flexibility, and molecular recognition

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Off-target activity of TNF-alpha inhibitors characterized by protein biochips

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

The specificity of cross‐reactivity: Promiscuous antibody binding involves specific hydrogen bonds rather than nonspecific hydrophobic stickiness

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Structural plasticity and the evolution of antibody affinity and specificity

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Serine 132 is the C3 covalent attachment point on the CH1 domain of human IgG1.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3218534

Complement in BuB/BnJ mice revisited: serum C3 levels and complement opsonic activity are not elevated

26 September 2018

1 reference

12 December 2020

IL-12: monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts

1 reference

12 December 2020

Covalent attachment of human complement C3 to IgG. Identification of the amino acid residue involved in ester linkage formation

1 reference

12 December 2020

Preclinical safety evaluation of monoclonal antibodies

1 reference

12 December 2020

Determination and validation of off-target activities of anti-CD44 variant 6 antibodies using protein biochips and tissue microarrays

1 reference

12 December 2020

Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab

1 reference

12 December 2020

Protein microchips: use for immunoassay and enzymatic reactions

1 reference

12 December 2020

Identifiers

DOI

10.4161/MABS.3.4.15786

1 reference

8 August 2017

1 reference

8 August 2017

1 reference