Roles of eukaryotic topoisomerases in transcription, replication and genomic stability (Q38959828)

8 September 2017

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title

Roles of eukaryotic topoisomerases in transcription, replication and genomic stability (English)

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8 September 2017

1

Yves Pommier

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8 September 2017

4

John L Nitiss

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8 September 2017

Yilun Sun

2

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PubMed ID

27649880

8 September 2017

Shar-Yin N Huang

series ordinal

3

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8 September 2017

21 September 2016

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Nature Reviews Molecular Cell Biology

8 September 2017

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8 September 2017

17

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8 September 2017

11

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8 September 2017

703-721

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https://scigraph.springernature.com/pub.10.1038/nrm.2016.111

8 September 2017

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All tangled up: how cells direct, manage and exploit topoisomerase function

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Topoisomerase-mediated chromosomal break repair: an emerging player in many games

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Cellular strategies for regulating DNA supercoiling: a single-molecule perspective

31 March 2020

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Bacterial and archeal type I topoisomerases

31 March 2020

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DNA topoisomerase II enzymes as molecular targets for cancer chemotherapy

31 March 2020

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Single-molecule measurements of topoisomerase activity with magnetic tweezers

31 March 2020

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A consensus sequence for cleavage by vertebrate DNA topoisomerase II.

31 March 2020

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The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.

31 March 2020

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Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin.

31 March 2020

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Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps. Importance of DNA end phosphorylation and camptothecin effects

31 March 2020

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Effects of base mutations on topoisomerase II DNA cleavage stimulated by mAMSA in short DNA oligomers

31 March 2020

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Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2⋅DNA and Top2⋅RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2016.111

Human mitochondrial topoisomerase I

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2016.111

Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2016.111

Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria

31 March 2020

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Nucleosome positioning as a critical determinant for the DNA cleavage sites of mammalian DNA topoisomerase II in reconstituted simian virus 40 chromatin.

31 March 2020

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Topoisomerase II, not topoisomerase I, is the proficient relaxase of nucleosomal DNA.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2016.111

Transcription-dependent dynamic supercoiling is a short-range genomic force

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2016.111

Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Interplay between DNA supercoiling and transcription elongation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Mammalian DNA topoisomerase I activity and poisoning by camptothecin are inhibited by simian virus 40 large T antigen

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Bidirectional DNA unwinding by a ternary complex of T antigen, nucleolin and topoisomerase I

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Interaction of human nuclear topoisomerase I with guanosine quartet-forming and guanosine-rich single-stranded DNA and RNA oligonucleotides

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

BAF complexes facilitate decatenation of DNA by topoisomerase IIα

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Reversible Top1 cleavage complexes are stabilized strand-specifically at the ribosomal replication fork barrier and contribute to ribosomal DNA stability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

A rationale to target the SWI/SNF complex for cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

DNA topoisomerase I is involved in both repression and activation of transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Identification of human DNA topoisomerase I as a cofactor for activator-dependent transcription by RNA polymerase II.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Topoisomerase I enhances TFIID-TFIIA complex assembly during activation of transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

NKX3.1 homeodomain protein binds to topoisomerase I and enhances its activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Ligand-dependent enhancer activation regulated by topoisomerase-I activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Identification and characterization of the genes for two topoisomerase I-interacting proteins from Saccharomyces cerevisiae

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Silver staining the chromosome scaffold

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Reconstitution of mitotic chromatids with a minimum set of purified factors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

The α isoform of topoisomerase II is required for hypercompaction of mitotic chromosomes in human cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

SUMO-2/3 regulates topoisomerase II in mitosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Supercoiling of the DNA template during transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Topoisomerase II binds nucleosome-free DNA and acts redundantly with topoisomerase I to enhance recruitment of RNA Pol II in budding yeast.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

DNA Topoisomerases maintain promoters in a state competent for transcriptional activation in Saccharomyces cerevisiae

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

DNA Topoisomerases Are Required for Preinitiation Complex Assembly during GAL Gene Activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Transcription-induced DNA double strand breaks: both oncogenic force and potential therapeutic target?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Glucocorticoid Receptor Transcriptional Activation via the BRG1-Dependent Recruitment of TOP2β and Ku70/86.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Role of topoisomerase IIbeta in the expression of developmentally regulated genes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Transcriptional elongation requires DNA break-induced signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Topoisomerase II is required for the production of long Pol II gene transcripts in yeast

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

The anti-cancer drug camptothecin inhibits elongation but stimulates initiation of RNA polymerase II transcription.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Transcription poisoning by Topoisomerase I is controlled by gene length, splice sites, and miR-142-3p

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Topoisomerases facilitate transcription of long genes linked to autism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Topoisomerase 1 inhibition reversibly impairs synaptic function.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Growth inhibition mediated by excess negative supercoiling: the interplay between transcription elongation, R-loop formation and DNA topology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

R loops: new modulators of genome dynamics and function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Preferential cleavage of plasmid-based R-loops and D-loops by Drosophila topoisomerase IIIbeta

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

The role of topoisomerase I in suppressing genome instability associated with a highly transcribed guanine-rich sequence is not restricted to preventing RNA:DNA hybrid accumulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

DNA double-strand breaks and ATM activation by transcription-blocking DNA lesions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

In front of and behind the replication fork: bacterial type IIA topoisomerases.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Function of DNA topoisomerases as replication swivels in Saccharomyces cerevisiae

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Functional interactions of DNA topoisomerases with a human replication origin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Binding of DNA topoisomerases I and II to replication origins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Proteins of the origin recognition complex (ORC) and DNA topoisomerases on mammalian chromatin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Effects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Replication initiated at the origin (oriC) of the E. coli chromosome reconstituted with purified enzymes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Knot what we thought before: the twisted story of replication

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2016.111

Topological challenges to DNA replication: conformations at the fork

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2016.111

Topoisomerase II can unlink replicating DNA by precatenane removal

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Direct Evidence for the Formation of Precatenanes during DNA Replication

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Terminal stages of SV40 DNA replication proceed via multiply intertwined catenated dimers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Arrest of segregation leads to accumulation of highly intertwined catenated dimers: Dissection of the final stages of SV40 DNA replication

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

"Breaking up is hard to do": the formation and resolution of sister chromatid intertwines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Synthesis and dissolution of hemicatenanes by type IA DNA topoisomerases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Local and global functions of Timeless and Tipin in replication fork protection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

The many facets of the Tim-Tipin protein families' roles in chromosome biology.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Tipin functions in the protection against topoisomerase I inhibitor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Chromosome length and perinuclear attachment constrain resolution of DNA intertwines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Chromosome length influences replication-induced topological stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

A topoisomerase II-dependent mechanism for resetting replicons at the S-M-phase transition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Chromosome breakage is regulated by the interaction of the BLM helicase and topoisomerase IIalpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Bloom's syndrome and PICH helicases cooperate with topoisomerase IIα in centromere disjunction before anaphase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosome breakage.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

New insights into the formation and resolution of ultra-fine anaphase bridges

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

The origins and processing of ultra fine anaphase DNA bridges.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Small molecule modulation of the human chromatid decatenation checkpoint

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

The human decatenation checkpoint.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells/.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

BRCA1 participates in DNA decatenation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

PTEN stabilizes TOP2A and regulates the DNA decatenation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

PIASgamma is required for faithful chromosome segregation in human cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Shaping mitotic chromosomes: From classical concepts to molecular mechanisms.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Condensing chromosome condensation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Positive supercoiling of mitotic DNA drives decatenation by topoisomerase II in eukaryotes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Tissue-specific mtDNA abundance from exome data and its correlation with mitochondrial transcription, mass and respiratory activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Mitochondrial topoisomerase I (top1mt) is a novel limiting factor of doxorubicin cardiotoxicity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Drosophila mitochondrial topoisomerase III alpha affects the aging process via maintenance of mitochondrial function and genome integrity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Poisoning of mitochondrial topoisomerase I by lamellarin D

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Interfacial inhibitors: targeting macromolecular complexes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Drugging topoisomerases: lessons and challenges

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Repair and genetic consequences of endogenous DNA base damage in mammalian cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

31 March 2020

Oxidative Decay of DNA

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

DNA Damage, Aging, and Cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Genome instability due to ribonucleotide incorporation into DNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Processing ribonucleotides incorporated during eukaryotic DNA replication.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Site-specific ribonuclease activity of eukaryotic DNA topoisomerase I.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Topoisomerase I alone is sufficient to produce short DNA deletions and can also reverse nicks at ribonucleotide sites

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Position-specific effect of ribonucleotides on the cleavage activity of human topoisomerase II.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

End-processing nucleases and phosphodiesterases: An elite supporting cast for the non-homologous end joining pathway of DNA double-strand break repair

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Neuroprotection and repair of 3'-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesterase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

DNA topoisomerase-targeting antitumor drugs can be studied in yeast

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Differential and common DNA repair pathways for topoisomerase I- and II-targeted drugs in a genetic DT40 repair cell screen panel

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

An RNA virus hijacks an incognito function of a DNA repair enzyme

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Roles of nonhomologous end-joining pathways in surviving topoisomerase II-mediated DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Repair synthesis step involving ERCC1-XPF participates in DNA repair of the Top1-DNA damage complex.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

DNA repair functions that control sensitivity to topoisomerase-targeting drugs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

FEN1 participates in repair of the 5'-phosphotyrosyl terminus of DNA single-strand breaks

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

MRE11 function in response to topoisomerase poisons is independent of its function in double-strand break repair in Saccharomyces cerevisiae

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

DNA repair factor MRE11/RAD50 cleaves 3'-phosphotyrosyl bonds and resects DNA to repair damage caused by topoisomerase 1 poisons.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Human CtIP promotes DNA end resection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Topoisomerase II and leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Do transcription factories and TOP2B provide a recipe for chromosome translocations in therapy-related leukemia?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Molecular pathogenesis of secondary acute promyelocytic leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Mutation of a conserved active site residue converts tyrosyl-DNA phosphodiesterase I into a DNA topoisomerase I-dependent poison

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Anti-Scl-70 (topo-I) antibodies in SLE: Myth or reality?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Self-organization of meiotic recombination initiation: general principles and molecular pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Cost of rNTP/dNTP pool imbalance at the replication fork

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Mechanism and regulation of meiotic recombination initiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

8-Oxoguanine rearranges the active site of human topoisomerase I

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Abasic sites stimulate double-stranded DNA cleavage mediated by topoisomerase II. DNA lesions as endogenous topoisomerase II poisons

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Topoisomerase II-mediated DNA cleavage and religation in the absence of base pairing. Abasic lesions as a tool to dissect enzyme mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Apurinic sites are position-specific topoisomerase II poisons.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Induction of topoisomerase I cleavage complexes by the vinyl chloride adduct 1,N6-ethenoadenine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Position-specific trapping of topoisomerase I-DNA cleavage complexes by intercalated benzo[a]- pyrene diol epoxide adducts at the 6-amino group of adenine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Different effects on human topoisomerase I by minor groove and intercalated deoxyguanosine adducts derived from two polycyclic aromatic hydrocarbon diol epoxides at or near a normal cleavage site

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N2-ethyl-2'-deoxyguanosine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: implications for interactions with intercalating anticancer agents

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

DNA recombinase activity of eukaryotic DNA topoisomerase I; effects of camptothecin and other inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

DNA topoisomerase I-mediated formation of structurally modified DNA duplexes. Effects of metal ions and topoisomerase I inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Human DNA topoisomerase I-mediated cleavages stimulated by ultraviolet light-induced DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Stimulated activity of human topoisomerases IIalpha and IIbeta on RNA-containing substrates

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

A breaking strategy for topoisomerase IIbeta/PARP-1-dependent regulated transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Promoter cleavage: a topoIIbeta and PARP-1 collaboration.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2016.111

Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine.

31 March 2020

1 reference

12 December 2020

Phosphorylation of mammalian DNA topoisomerase I and activation by protein kinase C.

1 reference

12 December 2020

Apoptotic topoisomerase I-DNA complexes induced by oxygen radicals and mitochondrial dysfunction

1 reference

12 December 2020

Inhibition of eukaryotic topoisomerase II by ultraviolet-induced cyclobutane pyrimidine dimers.

1 reference

12 December 2020

Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin

1 reference

12 December 2020

Werner protein stimulates topoisomerase I DNA relaxation activity

1 reference

12 December 2020

DNA topoisomerases: why so many?

1 reference

12 December 2020

Ultraviolet-induced DNA damage stimulates topoisomerase I-DNA complex formation in vivo: possible relationship with DNA repair

1 reference

12 December 2020

Replication initiation and DNA topology: The twisted life of the origin

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRM.2016.111

1 reference

PubMed ID

27649880

Dimensions Publication ID

8 September 2017

0 references

1 reference

PubMed ID

27649880