SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity (Q33854172)

29 July 2017

SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity (English)

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29 July 2017

3

Thomas E Kehl-Fie

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29 July 2017

Heidrun Interthal

1

1 reference

29 July 2017

Hong Jing Chen

2

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29 July 2017

Jörg Zotzmann

4

1 reference

29 July 2017

John B Leppard

5

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29 July 2017

James J Champoux

6

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29 July 2017

language of work or name

English

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publication date

26 May 2005

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29 July 2017

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29 July 2017

24

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29 July 2017

2224-2233

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29 July 2017

12

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describes a project that uses

29 July 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1150888/fullTextXML

inferred from PubMed Central ID database lookup

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Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

28 July 2018

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DNA single-strand breaks and neurodegeneration

28 July 2018

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Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes

28 July 2018

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Engineered resistance to camptothecin and antifolates by retroviral coexpression of tyrosyl DNA phosphodiesterase-I and thymidylate synthase

28 July 2018

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Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide

28 July 2018

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DNA single-strand break repair and spinocerebellar ataxia

28 July 2018

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Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

28 July 2018

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Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage

28 July 2018

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Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy

28 July 2018

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Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

28 July 2018

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The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1

28 July 2018

1 reference

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The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin

28 July 2018

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Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene

28 July 2018

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The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

28 July 2018

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DNA topoisomerases: structure, function, and mechanism

28 July 2018

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Genome maintenance mechanisms for preventing cancer

28 July 2018

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Topoisomerase I-mediated DNA damage

28 July 2018

1 reference

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Linking DNA damage and neurodegeneration

28 July 2018

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Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes

28 July 2018

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Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

28 July 2018

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Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

28 July 2018

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A model for the mechanism of human topoisomerase I

28 July 2018

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A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

28 July 2018

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28 July 2018

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DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes

28 July 2018

1 reference

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Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity

28 July 2018

1 reference

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Different fates of camptothecin-induced replication fork-associated double-strand DNA breaks in mammalian cells

28 July 2018

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A novel suicide substrate for DNA topoisomerases and site-specific recombinases

28 July 2018

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Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin

28 July 2018

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The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.

28 July 2018

1 reference

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Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells

28 July 2018

1 reference

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TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II

28 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600694

Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600694

The role of TDP1 from budding yeast in the repair of DNA damage

21 January 2018

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Investigating the biological functions of DNA topoisomerases in eukaryotic cells

21 January 2018

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Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600694

Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae

21 January 2018

1 reference

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Analysis of human tyrosyl-DNA phosphodiesterase I catalytic residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600694

Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600694

Cellular roles of dna topoisomerases: a molecular perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600694

DNA repair in terminally differentiated cells

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1150888

ICE bioassay. Isolating in vivo complexes of enzyme to DNA.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1150888

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

29 October 2018

1 reference

12 December 2020

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons

1 reference

12 December 2020

Detection of apoptosis in live cells by MitoTracker red CMXRos and SYTO dye flow cytometry

1 reference

12 December 2020

Down-regulation of DNA replication in extracts of camptothecin-treated cells: activation of an S-phase checkpoint?

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.EMBOJ.7600694

1 reference

29 July 2017

1 reference

29 July 2017

1 reference