Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders. (Q38818474)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27660272%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

review article

1 reference

title

Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27660272%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

0 references

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27660272%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Brígida R Pinho

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27660272%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Jorge M. A. Oliveira

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27660272%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

author name string

Sara D Reis

1

1 reference

6 September 2017

Brígida R Pinho

2

1 reference

6 September 2017

Jorge M A Oliveira

3

1 reference

6 September 2017

22 September 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27660272%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

published in

Molecular Neurobiology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27660272%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

volume

54

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27660272%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27660272%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

page(s)

5829-5854

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27660272%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s12035-016-0120-z

23 March 2020

exact match

0 references

cites work

Proteostasis impairment in protein-misfolding and -aggregation diseases

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Adapting proteostasis for disease intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Molecular chaperones in protein folding and proteostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Molecular chaperone functions in protein folding and proteostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

21 January 2018

The heat-shock response

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Hsp90 interaction with clients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Protein rescue from aggregates by powerful molecular chaperone machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Molecular chaperones and neuronal proteostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Small heat shock proteins and α-crystallins: dynamic proteins with flexible functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

HSPBs: small proteins with big implications in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Nature's molecular sponges: small heat shock proteins grow into their chaperone roles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

A global view of Hsp90 functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Hsp70 chaperone dynamics and molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

The biology of proteostasis in aging and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

21 January 2018

Proteostasis and aging

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

PolyQ disease: misfiring of a developmental cell death program?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Trinucleotide Repeat Disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Cell biology of spinocerebellar ataxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Pathogenesis and therapy of spinal and bulbar muscular atrophy (SBMA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Targeting the molecular chaperone heat shock protein 90 (HSP90): lessons learned and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Hsp70 in cancer: back to the future

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Impaired heat shock response in cells expressing full-length polyglutamine-expanded huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Heat shock factors: integrators of cell stress, development and lifespan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Regulation of HSF1 function in the heat stress response: implications in aging and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Chaperone machines for protein folding, unfolding and disaggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

The Hsp90 mosaic: a picture emerges

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Hsp90-Tau complex reveals molecular basis for specificity in chaperone action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Modulation of the Hsp90 chaperone cycle by a stringent client protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

The chaperone Hsp90: changing partners for demanding clients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

The Hsp90 chaperone machinery: conformational dynamics and regulation by co-chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Evolution and function of diverse Hsp90 homologs and cochaperone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Co-chaperones of the mammalian endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

GRP94 in ER quality control and stress responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

The peptide-binding activity of GRP94 is regulated by calcium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Hsp90 regulation of mitochondrial protein folding: from organelle integrity to cellular homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Reprint of "The mitochondrial permeability transition pore and its adaptive responses in tumor cells".

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

TRAP1 rescues PINK1 loss-of-function phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Mitochondrial TRAP1 regulates the unfolded protein response in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

TRAP1 and the proteasome regulatory particle TBP7/Rpt3 interact in the endoplasmic reticulum and control cellular ubiquitination of specific mitochondrial proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Inhibition of HSP90 molecular chaperones: moving into the clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Targeting heat shock proteins 70/90 and proteasome for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Development of a Grp94 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Metazoan Hsp70-based protein disaggregases: emergence and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Multifaceted role of heat shock protein 70 in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Heat-shock cognate 70 is required for the activation of heat-shock factor 1 in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Chaperone-mediated autophagy: a unique way to enter the lysosome world

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Protein quality control in the ER: the recognition of misfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Importing mitochondrial proteins: machineries and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Mitochondrial protein import: from proteomics to functional mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Mitochondrial protein import: common principles and physiological networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

On the mechanism of preprotein import by the mitochondrial presequence translocase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

A small molecule inhibitor of inducible heat shock protein 70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Chemical manipulation of hsp70 ATPase activity regulates tau stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

A small molecule inhibitor of ATPase activity of HSP70 induces apoptosis and has antitumor activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Chaperone-assisted degradation: multiple paths to destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Constitutive upregulation of chaperone-mediated autophagy in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta: implications for a proteasome-to-autophagy switch.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

CHIP: a co-chaperone for degradation by the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Diseases of unstable repeat expansion: mechanisms and common principles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Clinical features, neurogenetics and neuropathology of the polyglutamine spinocerebellar ataxias type 1, 2, 3, 6 and 7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Huntington's disease: underlying molecular mechanisms and emerging concepts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Network organization of the huntingtin proteomic interactome in mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Mitochondrial dynamics and quality control in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Mitochondrial bioenergetics and dynamics in Huntington's disease: tripartite synapses and selective striatal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Could successful (mitochondrial) networking help prevent Huntington's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Nature and cause of mitochondrial dysfunction in Huntington's disease: focusing on huntingtin and the striatum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Inhibition of mitochondrial protein import by mutant huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Global changes to the ubiquitin system in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Regional and cellular gene expression changes in human Huntington's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Potential function for the Huntingtin protein as a scaffold for selective autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Heat shock response activation exacerbates inclusion body formation in a cellular model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

A screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Modulation of polyglutamine inclusion formation by the Hsp70 chaperone machine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Suppression of protein aggregation by chaperone modification of high molecular weight complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Heat shock transcription factor 1-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Small-molecule proteostasis regulators for protein conformational diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Polyglutamine neurodegeneration: expanded glutamines enhance native functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Mitochondrial abnormalities in spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

17-AAG increases autophagic removal of mutant androgen receptor in spinal and bulbar muscular atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Astroglial activation accompanies heat shock protein upregulation in rat brain following single oral dose of geranylgeranylacetone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Pharmacological induction of heat shock protein exerts neuroprotective effects in experimental intracerebral hemorrhage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Long-term disease progression in spinocerebellar ataxia types 1, 2, 3, and 6: a longitudinal cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Atrophins' emerging roles in development and neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Dentatorubral-pallidoluysian atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

The spinocerebellar ataxia type 1 protein, ataxin-1, has RNA-binding activity that is inversely affected by the length of its polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Gene profiling links SCA1 pathophysiology to glutamate signaling in Purkinje cells of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Spinocerebellar ataxia type 2: clinical presentation, molecular mechanisms, and therapeutic perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Toward understanding Machado-Joseph disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Toward therapeutic targets for SCA3: Insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Molecular mechanism of Spinocerebellar Ataxia type 6: glutamine repeat disorder, channelopathy and transcriptional dysregulation. The multifaceted aspects of a single mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Second cistron in CACNA1A gene encodes a transcription factor mediating cerebellar development and SCA6

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

The carboxy-terminal fragment of alpha(1A) calcium channel preferentially aggregates in the cytoplasm of human spinocerebellar ataxia type 6 Purkinje cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Polyglutamine-expanded ataxin-7 causes cerebellar dysfunction by inducing transcriptional dysregulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Brain pathology of spinocerebellar ataxias

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Conservation between the RNA polymerase I, II, and III transcription initiation machineries

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Structural basis of transcription initiation by RNA polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Polyglutamine expansion reduces the association of TATA-binding protein with DNA and induces DNA binding-independent neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Transcriptional dysregulation of TrkA associates with neurodegeneration in spinocerebellar ataxia type 17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

DRPLA transgenic mouse substrains carrying single copy of full-length mutant human DRPLA gene with variable sizes of expanded CAG repeats exhibit CAG repeat length- and age-dependent changes in behavioral abnormalities and gene expression profiles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Co-chaperone CHIP promotes aggregation of ataxin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Hsp70 and Hsp40 chaperones do not modulate retinal phenotype in SCA7 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

The potential of indole and a synthetic derivative for polyQ aggregation reduction by enhancement of the chaperone and autophagy systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Chronic treatment with 17-DMAG improves balance and coordination in a new mouse model of Machado-Joseph disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Chemical induction of Hsp70 reduces α-synuclein aggregation in neuroglioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Novel mechanism of Hsp70 chaperone-mediated prevention of polyglutamine aggregates in a cellular model of huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

GRP78 counteracts cell death and protein aggregation caused by mutant huntingtin proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Hsp40 molecules that target to the ubiquitin-proteasome system decrease inclusion formation in models of polyglutamine disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Deficit of heat shock transcription factor 1-heat shock 70 kDa protein 1A axis determines the cell death vulnerability in a model of spinocerebellar ataxia type 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Small molecule inducers of heat-shock response reduce polyQ-mediated huntingtin aggregation. A possible therapeutic strategy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Hsp90: breaking the symmetry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0120-Z

Selectivity of the molecular chaperone-specific immunosuppressive agent 15-deoxyspergualin: modulation of Hsc70 ATPase activity without compromising DnaJ chaperone interactions

21 January 2018

1 reference

12 December 2020

HSP70 interacting protein prevents the accumulation of inclusions in polyglutamine disease

1 reference

12 December 2020

Quantitation of the interaction of the immunosuppressant deoxyspergualin and analogs with Hsc70 and Hsp90

1 reference

12 December 2020

Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract

1 reference

12 December 2020

The induction mechanism of the molecular chaperone HSP70 in the gastric mucosa by Geranylgeranylacetone (HSP-inducer)

1 reference

12 December 2020

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

1 reference

12 December 2020

Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

1 reference

12 December 2020