Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase (Q27713462)

5

0 references

Yanxin Liu

object named as

Yanxin Liu

4

0 references

Shigeyuki Yokoyama

object named as

Shigeyuki Yokoyama

6

0 references

Akihiko Arakawa

3

object named as

Akihiko Arakawa

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author name string

Kliment A Verba

1

0 references

Ray Yu-Ruei Wang

2

0 references

David A Agard

Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles

7

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language of work or name

English

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publication date

24 June 2016

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published in

Science

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volume

352

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issue

6293

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page(s)

1542-7

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cites work

1 reference

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Structural Asymmetry in the Closed State of Mitochondrial Hsp90 (TRAP1) Supports a Two-Step ATP Hydrolysis Mechanism

7 April 2017

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Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

7 April 2017

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Crystal structure of human CDK4 in complex with a D-type cyclin

7 April 2017

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The structure of CDK4/cyclin D3 has implications for models of CDK activation

7 April 2017

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Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones

7 April 2017

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The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

7 April 2017

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High cleavage efficiency of a 2A peptide derived from porcine teschovirus-1 in human cell lines, zebrafish and mice

7 April 2017

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EMAN2: an extensible image processing suite for electron microscopy

22 April 2017

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UCSF Chimera--a visualization system for exploratory research and analysis

22 April 2017

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Conventions and workflows for using Situs

22 April 2017

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Scalable molecular dynamics with NAMD

22 April 2017

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MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

22 April 2017

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Features and development of Coot

22 April 2017

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Targeting cancer with small molecule kinase inhibitors

22 April 2017

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RELION: implementation of a Bayesian approach to cryo-EM structure determination

7 April 2017

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HSP90 at the hub of protein homeostasis: emerging mechanistic insights

22 April 2017

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Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex

7 April 2017

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Flexible fitting of atomic structures into electron microscopy maps using molecular dynamics

7 April 2017

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Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy

22 April 2017

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Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90.

22 April 2017

1 reference

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Single-Particle Cryo-EM at Crystallographic Resolution

29 September 2017

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Hsp90: breaking the symmetry.

29 September 2017

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Phosphorylated and unphosphorylated serine 13 of CDC37 stabilize distinct interactions between its client and HSP90 binding domains

29 September 2017

1 reference

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Hsp90 promotes kinase evolution

29 September 2017

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Transitions to catalytically inactive conformations in EGFR kinase

29 September 2017

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ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system

29 September 2017

1 reference

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Uncovering a region of heat shock protein 90 important for client binding in E. coli and chaperone function in yeast.

29 September 2017

1 reference

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The therapeutic target Hsp90 and cancer hallmarks

29 September 2017

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Evolution of the eukaryotic protein kinases as dynamic molecular switches

29 September 2017

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The structural basis for control of eukaryotic protein kinases

29 September 2017

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Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity

29 September 2017

1 reference

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Conformational dynamics of the molecular chaperone Hsp90

29 September 2017

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Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.

29 September 2017

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Structure of an Hsp90-Cdc37-Cdk4 complex.

29 September 2017

1 reference

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Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.

29 September 2017

1 reference

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Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins

29 September 2017

1 reference

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Interaction Between the Rous Sarcoma Virus Transforming Protein and Two Cellular Phosphoproteins: Analysis of the Turnover and Distribution of This Complex

29 September 2017

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Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites

29 September 2017

1 reference

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Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells

2 June 2018

1 reference

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Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90) motility by interaction with N-terminal and middle domain binding sites

2 June 2018

1 reference

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Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle

2 June 2018

1 reference

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Functional Dissection of Cdc37: Characterization of Domain Structure and Amino Acid Residues Critical for Protein Kinase Binding

2 June 2018

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Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM.

21 January 2018

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Structure of the TRPV1 ion channel determined by electron cryo-microscopy

21 January 2018

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CTFFIND4: Fast and accurate defocus estimation from electron micrographs.

21 January 2018

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Beam-induced motion correction for sub-megadalton cryo-EM particles.

21 January 2018

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High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

21 January 2018

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Sampling the conformational space of the catalytic subunit of human γ-secretase

21 January 2018

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CATH: comprehensive structural and functional annotations for genome sequences.

21 January 2018

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De novo protein structure determination from near-atomic-resolution cryo-EM maps

21 January 2018

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High-resolution comparative modeling with RosettaCM.

21 January 2018

1 reference

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Molybdate inhibits hsp90, induces structural changes in its C-terminal domain, and alters its interactions with substrates

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/27339980