Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation (Q36553586)

14 August 2017

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation (English)

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14 August 2017

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Adrienne M Wang

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14 August 2017

Yoshinari Miyata

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14 August 2017

Susan Klinedinst

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14 August 2017

Hwei-Ming Peng

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14 August 2017

Jason P Chua

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Tomoko Komiyama

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14 August 2017

Xiaokai Li

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14 August 2017

Yoshihiro Morishima

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14 August 2017

Diane E Merry

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14 August 2017

William B Pratt

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14 August 2017

Yoichi Osawa

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14 August 2017

Catherine A Collins

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14 August 2017

Jason E Gestwicki

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14 August 2017

Andrew P Lieberman

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14 August 2017

9 December 2012

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14 August 2017

Nature Chemical Biology

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112-118

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describes a project that uses

14 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3552084/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nchembio.1140

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cites work

Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination

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A screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein.

30 September 2017

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The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system

30 September 2017

1 reference

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Impaired motoneuronal retrograde transport in two models of SBMA implicates two sites of androgen action

30 September 2017

1 reference

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Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft

30 September 2017

1 reference

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Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism

30 September 2017

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C331A mutant of neuronal nitric-oxide synthase is labilized for Hsp70/CHIP (C terminus of HSC70-interacting protein)-dependent ubiquitination

30 September 2017

1 reference

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Mutagenesis reveals the complex relationships between ATPase rate and the chaperone activities of Escherichia coli heat shock protein 70 (Hsp70/DnaK)

30 September 2017

1 reference

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Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage

30 September 2017

1 reference

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Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation

30 September 2017

1 reference

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Heat shock protein 70 (hsp70) as an emerging drug target.

30 September 2017

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Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip

30 September 2017

1 reference

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Pharmacological targeting of the Hsp70 chaperone

30 September 2017

1 reference

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Altered RNA splicing contributes to skeletal muscle pathology in Kennedy disease knock-in mice

30 September 2017

1 reference

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HSP70 interacting protein prevents the accumulation of inclusions in polyglutamine disease

30 September 2017

1 reference

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Mitochondrial abnormalities in spinal and bulbar muscular atrophy

30 September 2017

1 reference

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CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts

30 September 2017

1 reference

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Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90.

30 September 2017

1 reference

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17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

30 September 2017

1 reference

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Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase

30 September 2017

1 reference

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CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

Chaperones increase association of tau protein with microtubules

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

Hsp70 chaperone machines.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

hsp70 interacting protein Hip does not affect glucocorticoid receptor folding by the hsp90-based chaperone machinery except to oppose the effect of BAG-1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

CREB-binding protein sequestration by expanded polyglutamine

30 September 2017

1 reference

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Treatment of ras-induced cancers by the F-actin-bundling drug MKT-077.

30 September 2017

1 reference

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Glutamine repeats and neurodegeneration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

Ubiquitination of neuronal nitric-oxide synthase in vitro and in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle

30 September 2017

1 reference

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Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait

30 September 2017

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Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function.

30 September 2017

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Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye.

28 June 2018

1 reference

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Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

High-throughput screen for Escherichia coli heat shock protein 70 (Hsp70/DnaK): ATPase assay in low volume by exploiting energy transfer.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brain

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

Ligand promotes intranuclear inclusions in a novel cell model of spinal and bulbar muscular atrophy

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552084

Short non-coding RNA biology and neurodegenerative disorders: novel disease targets and therapeutics

21 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1140

Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract

21 January 2018

1 reference

12 December 2020

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

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12 December 2020

X-linked recessive bulbospinal neuronopathy. A clinicopathological study

1 reference

12 December 2020

Reduced transcriptional regulatory competence of the androgen receptor in X-linked spinal and bulbar muscular atrophy

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12 December 2020

Nucleotide-induced conformational changes in the ATPase and substrate binding domains of the DnaK chaperone provide evidence for interdomain communication

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12 December 2020

Structure-activity of novel rhodacyanine dyes as antitumor agents

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12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.1140

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14 August 2017

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14 August 2017

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