Hsp90-Tau complex reveals molecular basis for specificity in chaperone action (Q24338439)

14

0 references

Dmitry B Veprintsev

Dmitry B Veprintsev

10

0 references

Eckhard Mandelkow

12

Eckhard Mandelkow

0 references

Elias Akoury

Elias Akoury

3

0 references

Tobias Madl

Tobias Madl

15

0 references

author name string

G Elif Karagöz

1

0 references

Afonso M S Duarte

2

0 references

Hans Ippel

4

0 references

Jacek Biernat

5

0 references

Tania Morán Luengo

6

0 references

Martina Radli

7

0 references

Tatiana Didenko

8

0 references

Bryce A Nordhues

9

0 references

Chad A Dickey

11

0 references

Stefan G D Rüdiger

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

16

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language of work or name

English

0 references

publication date

27 February 2014

0 references

published in

Cell

0 references

volume

156

0 references

issue

5

0 references

page(s)

963-74

0 references

cites work

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Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

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19 March 2017

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A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

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Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

19 March 2017

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

19 March 2017

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The Hsp90 chaperone machinery: conformational dynamics and regulation by co-chaperones

19 March 2017

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19 March 2017

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19 March 2017

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Molecular chaperones in protein folding and proteostasis

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HSP90 at the hub of protein homeostasis: emerging mechanistic insights

7 April 2017

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

7 April 2017

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Structure and mechanism of the Hsp90 molecular chaperone machinery

7 April 2017

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Molecular chaperones and protein quality control

7 April 2017

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7 April 2017

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Tau suppression in a neurodegenerative mouse model improves memory function

7 April 2017

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Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

7 April 2017

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7 April 2017

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Hsp90 inhibits α-synuclein aggregation by interacting with soluble oligomers.

27 September 2017

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Imbalance of Hsp70 family variants fosters tau accumulation

27 September 2017

1 reference

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Uncovering a region of heat shock protein 90 important for client binding in E. coli and chaperone function in yeast.

27 September 2017

1 reference

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Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation

27 September 2017

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Biochemistry and cell biology of tau protein in neurofibrillary degeneration

27 September 2017

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27 September 2017

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27 September 2017

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Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.

27 September 2017

1 reference

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Dynamic Interaction of Hsp90 with Its Client Protein p53.

27 September 2017

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Substrate binding drives large-scale conformational changes in the Hsp90 molecular chaperone

27 September 2017

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N-terminal domain of human Hsp90 triggers binding to the cochaperone p23.

27 September 2017

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Gymnastics of molecular chaperones

27 September 2017

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Nonlinear least-squares data fitting in Excel spreadsheets.

27 September 2017

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Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility

27 September 2017

1 reference

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Unfoldomics of human diseases: linking protein intrinsic disorder with diseases

27 September 2017

1 reference

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Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone.

27 September 2017

1 reference

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The Hsp90 molecular chaperone: an open and shut case for treatment

27 September 2017

1 reference

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Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

27 September 2017

1 reference

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The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

27 September 2017

1 reference

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Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements

27 September 2017

1 reference

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Structure of an Hsp90-Cdc37-Cdk4 complex.

27 September 2017

1 reference

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Novel insights into the mechanism of chaperone-assisted protein disaggregation

27 September 2017

1 reference

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Hsp70 and Hsp90--a relay team for protein folding

27 September 2017

1 reference

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The present view of the mechanism of protein folding

27 September 2017

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Chaperones increase association of tau protein with microtubules

27 September 2017

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Mapping protein-protein interactions in solution by NMR spectroscopy

27 September 2017

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Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

27 September 2017

1 reference

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The structure of the translational initiation factor IF1 from E.coli contains an oligomer-binding motif

27 September 2017

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Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries

27 September 2017

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Transient interaction of Hsp90 with early unfolding intermediates of citrate synthase. Implications for heat shock in vivo

27 September 2017

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27 September 2017

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27 September 2017

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Grp94, the endoplasmic reticulum Hsp90, has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide

30 May 2018

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30 May 2018

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30 May 2018

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29 November 2018

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Domain conformation of tau protein studied by solution small-angle X-ray scattering

29 November 2018

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Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

29 November 2018

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29 November 2018

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Identifiers

DOI

10.1016/J.CELL.2014.01.037

1 reference

991838

991838

1 reference

1 reference

1 reference