Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils (Q35753373)

10 August 2017

Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils (English)

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10 August 2017

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Marta Carroni

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Matthias P. Mayer

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Matthias P Mayer

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Bernd Bukau

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Bernd Bukau

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Axel Mogk

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Helen R Saibil

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Nadinath B Nillegoda

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Xuechao Gao

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D Lys Guilbride

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Anna Szlachcic

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10 August 2017

Carmen Nussbaum-Krammer

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10 August 2017

19 August 2015

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781-793

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PubMed ID

26300264

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10 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5072489/fullTextXML

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cites work

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2 October 2017

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2 October 2017

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2 October 2017

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Hsp110 is a bona fide chaperone using ATP to unfold stable misfolded polypeptides and reciprocally collaborate with Hsp70 to solubilize protein aggregates.

2 October 2017

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2 October 2017

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2 October 2017

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Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

2 October 2017

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2 October 2017

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Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans

2 October 2017

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The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system

2 October 2017

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2 October 2017

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EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.

2 October 2017

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Discovery and characterization of a mammalian amyloid disaggregation activity

2 October 2017

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A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis

2 October 2017

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2 October 2017

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C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging

2 October 2017

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

2 October 2017

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A general model for amyloid fibril assembly based on morphological studies using atomic force microscopy

2 October 2017

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Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

2 October 2017

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Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity

2 October 2017

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2 October 2017

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A conserved HPD sequence of the J-domain is necessary for YDJ1 stimulation of Hsp70 ATPase activity at a site distinct from substrate binding

2 October 2017

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2 October 2017

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2 October 2017

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Sequence-specific rates of interaction of target peptides with the molecular chaperones DnaK and DnaJ.

12 July 2018

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Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation

12 July 2018

1 reference

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Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro.

25 September 2018

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25 September 2018

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Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers

25 September 2018

1 reference

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10.1016/J.MOLCEL.2015.07.012

25 September 2018

Identifiers

DOI

1 reference

10 August 2017

1 reference

10 August 2017

1 reference

PubMed ID

26300264