A20: from ubiquitin editing to tumour suppression (Q37728850)

22 August 2017

1 reference

title

A20: from ubiquitin editing to tumour suppression (English)

1 reference

22 August 2017

Sarah G Hymowitz

1

1 reference

22 August 2017

Ingrid E Wertz

series ordinal

2

1 reference

22 August 2017

language of work or name

English

0 references

publication date

12 April 2010

1 reference

22 August 2017

Nature Reviews Cancer

1 reference

22 August 2017

10

1 reference

22 August 2017

332-341

1 reference

22 August 2017

5

1 reference

https://scigraph.springernature.com/pub.10.1038/nrc2775

22 August 2017

0 references

cites work

Signalling platforms that modulate the inflammatory response: new targets for drug development

1 reference

Recent advances in understanding NF-kappaB regulation

31 March 2020

1 reference

Nuclear factor-kappaB in cancer development and progression

31 March 2020

1 reference

Inflammation and cancer: back to Virchow?

31 March 2020

1 reference

Inflammation and cancer: how friendly is the relationship for cancer patients?

31 March 2020

1 reference

31 March 2020

Inflammation and cancer

1 reference

The IkappaB kinase - a bridge between inflammation and cancer

31 March 2020

1 reference

Regulation and function of NF-kappaB transcription factors in the immune system

31 March 2020

1 reference

NF-kappaB and cancer: how intimate is this relationship

31 March 2020

1 reference

Regulation and function of IKK and IKK-related kinases

31 March 2020

1 reference

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

31 March 2020

1 reference

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

31 March 2020

1 reference

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

31 March 2020

1 reference

The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer

31 March 2020

1 reference

Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression

31 March 2020

1 reference

31 March 2020

The Hallmarks of Cancer

1 reference

Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls

31 March 2020

1 reference

Immunity by ubiquitylation: a reversible process of modification

31 March 2020

1 reference

Ubiquitin signalling in the NF-kappaB pathway

31 March 2020

1 reference

A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis

31 March 2020

1 reference

The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN

31 March 2020

1 reference

The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6

31 March 2020

1 reference

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

31 March 2020

1 reference

The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation

31 March 2020

1 reference

A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae

31 March 2020

1 reference

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

31 March 2020

1 reference

Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

31 March 2020

1 reference

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

31 March 2020

1 reference

Mechanisms underlying ubiquitination

31 March 2020

1 reference

Themes and variations on ubiquitylation

31 March 2020

1 reference

Ubiquitin in NF-kappaB signaling.

31 March 2020

1 reference

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

31 March 2020

1 reference

Otubains: a new family of cysteine proteases in the ubiquitin pathway

31 March 2020

1 reference

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

31 March 2020

1 reference

A novel type of deubiquitinating enzyme

31 March 2020

1 reference

Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity

31 March 2020

1 reference

Molecular Basis for the Unique Deubiquitinating Activity of the NF-κB Inhibitor A20

31 March 2020

1 reference

Structure of the A20 OTU domain and mechanistic insights into deubiquitination

31 March 2020

1 reference

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

31 March 2020

1 reference

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

31 March 2020

1 reference

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

31 March 2020

1 reference

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

31 March 2020

1 reference

Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation

31 March 2020

1 reference

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

31 March 2020

1 reference

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

31 March 2020

1 reference

Direct activation of protein kinases by unanchored polyubiquitin chains

31 March 2020

1 reference

A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

31 March 2020

1 reference

Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

31 March 2020

1 reference

Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies

31 March 2020

1 reference

IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway

31 March 2020

1 reference

Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions

31 March 2020

1 reference

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

31 March 2020

1 reference

Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation

31 March 2020

1 reference

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

31 March 2020

1 reference

The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain

31 March 2020

1 reference

Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5.

31 March 2020

1 reference

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin

31 March 2020

1 reference

Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80

31 March 2020

1 reference

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

31 March 2020

1 reference

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

31 March 2020

1 reference

The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling

31 March 2020

1 reference

Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2).

31 March 2020

1 reference

Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes

31 March 2020

1 reference

The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.

31 March 2020

1 reference

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

31 March 2020

1 reference

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

31 March 2020

1 reference

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.

31 March 2020

1 reference

The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals

31 March 2020

1 reference

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

31 March 2020

1 reference

Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20.

31 March 2020

1 reference

A20: central gatekeeper in inflammation and immunity

31 March 2020

1 reference

The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation

31 March 2020

1 reference

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

31 March 2020

1 reference

TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in ocular adnexal marginal zone B cell lymphoma.

31 March 2020

1 reference

The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas.

31 March 2020

1 reference

Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.

31 March 2020

1 reference

Frequent inactivation of A20 in B-cell lymphomas

31 March 2020

1 reference

TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas

31 March 2020

1 reference

A20 deletion is associated with copy number gain at the TNFA/B/C locus and occurs preferentially in translocation-negative MALT lymphoma of the ocular adnexa and salivary glands.

31 March 2020

1 reference

A20 is targeted by promoter methylation, deletion and inactivating mutation in MALT lymphoma

31 March 2020

1 reference

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

31 March 2020

1 reference

Mutations in the genes coding for the NF-κB regulating factors IκBα and A20 are uncommon in nodular lymphocyte-predominant Hodgkin's lymphoma

31 March 2020

1 reference

Multifunctional roles for MALT1 in T-cell activation.

31 March 2020

1 reference

Localization of A20 to a lysosome-associated compartment and its role in NFkappaB signaling

31 March 2020

1 reference

The inhibitor of apoptosis proteins as therapeutic targets in cancer

31 March 2020

1 reference

The role of NF-kappaB in lymphoid malignancies

31 March 2020

1 reference

RING domain E3 ubiquitin ligases

31 March 2020

1 reference

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

31 March 2020

1 reference

Generation and characterization of LymphoStat‐B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator

31 March 2020

1 reference

Denosumab for prevention of fractures in postmenopausal women with osteoporosis

31 March 2020

1 reference

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

31 March 2020

1 reference

Linear polyubiquitination: a new regulator of NF-kappaB activation.

31 March 2020

1 reference

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

31 March 2020

1 reference

Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology

31 March 2020

1 reference

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex

31 March 2020

1 reference

Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

31 March 2020

1 reference

Polyubiquitin binding and disassembly by deubiquitinating enzymes

31 March 2020

1 reference

ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB

31 March 2020

1 reference

A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains.

31 March 2020

1 reference

A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome

31 March 2020

1 reference

The A20 protein interacts with the Epstein-Barr virus latent membrane protein 1 (LMP1) and alters the LMP1/TRAF1/TRADD complex

31 March 2020

1 reference

Functional proteomics mapping of a human signaling pathway

31 March 2020

1 reference

The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases

31 March 2020

1 reference

A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter

31 March 2020

1 reference

Human T cell leukemia virus type I Tax and phorbol 12-myristate 13-acetate induce expression of the A20 zinc finger protein by distinct mechanisms involving nuclear factor kappa B.

31 March 2020

1 reference

12 December 2020

TRAF2: a double-edged sword?

1 reference

12 December 2020

The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein

1 reference

12 December 2020

Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements

1 reference

12 December 2020

Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC2775

1 reference

release_wfvfzc56pbcitaawen5b4jkche

22 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/wfvfzc56pbcitaawen5b4jkche

24 November 2022

mapped directly with Wikidata item

1 reference