Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function (Q39239626)

10 September 2017

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function (English)

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10 September 2017

6

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10 September 2017

Jason W Locasale

5

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author name string

Rachael Baker

1

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10 September 2017

Steven M Lewis

2

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10 September 2017

Atsuo T Sasaki

3

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10 September 2017

Emily M Wilkerson

4

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10 September 2017

Brian Kuhlman

7

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10 September 2017

Henrik G Dohlman

8

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10 September 2017

Sharon L Campbell

9

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10 September 2017

25 November 2012

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Nature Structural & Molecular Biology

10 September 2017

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10 September 2017

20

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1

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10 September 2017

46-52

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https://scigraph.springernature.com/pub.10.1038/nsmb.2430

10 September 2017

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cites work

Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate

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A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity

10 September 2017

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ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules

10 September 2017

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The role of ubiquitylation and degradation in RhoGTPase signalling

10 September 2017

1 reference

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Genomic and biological characterization of exon 4 KRAS mutations in human cancer

10 September 2017

1 reference

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Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

Ubiquitin not only serves as a tag but also assists degradation by inducing protein unfolding

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

Ras oncogenes: split personalities

10 September 2017

1 reference

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A novel analytical method for in vivo phosphate tracking

10 September 2017

1 reference

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The Ras superfamily at a glance

10 September 2017

1 reference

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Structural analysis of autoinhibition in the Ras activator Son of sevenless

10 September 2017

1 reference

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Protein structure prediction using Rosetta

10 September 2017

1 reference

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The dark side of Ras: regulation of apoptosis

10 September 2017

1 reference

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Ras-effector interactions: after one decade

10 September 2017

1 reference

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Blocking oncogenic Ras signaling for cancer therapy

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

Protein regulation by monoubiquitin

10 September 2017

1 reference

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Small GTP-binding proteins

10 September 2017

1 reference

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The Ras branch of small GTPases: Ras family members don't fall far from the tree

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

Solution structure of the PDZ2 domain from human phosphatase hPTP1E and its interactions with C-terminal peptides from the Fas receptor

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

Structural analysis of the GAP-related domain from neurofibromin and its implications

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

G proteins, effectors and GAPs: structure and mechanism

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

10 September 2017

1 reference

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Backbone-dependent rotamer library for proteins. Application to side-chain prediction

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

ras oncogenes in human cancer: a review

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

Recurrent KRAS codon 146 mutations in human colorectal cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

The GTP binding motif: variations on a theme

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

Traceless and site-specific ubiquitination of recombinant proteins

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

Sequential assignment of the backbone nuclei (1H, 15N and 13C) of c-H-ras p21 (1-166).GDP using a novel 4D NMR strategy

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

Chemically ubiquitylated PCNA as a probe for eukaryotic translesion DNA synthesis.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

Differential modification of Ras proteins by ubiquitination

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

Ubiquitin manipulation by an E2 conjugating enzyme using a novel covalent intermediate.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537887

Aluminum fluoride associates with the small guanine nucleotide binding proteins.

21 August 2018

1 reference

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Structural and Functional Analysis of a Mutant Ras Protein That Is Insensitive to Nitric Oxide Activation†

21 August 2018

1 reference

Generation of a Mono-ubiquitinated PCNA Mimic by Click Chemistry

21 January 2018

1 reference

GEFs: master regulators of G-protein activation

21 January 2018

1 reference

Expeditious chemical synthesis of ubiquitinated peptides employing orthogonal protection and native chemical ligation

31 March 2020

1 reference

Kinetics of the transfer of ubiquitin from UbcH7 to E6AP

31 March 2020

1 reference

Recognizing and defining true Ras binding domains I: biochemical analysis

31 March 2020

1 reference

Sequential 1H NMR assignments and secondary structure identification of human ubiquitin

31 March 2020

1 reference

Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements

31 March 2020

1 reference

Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm

31 March 2020

1 reference

Real-time in vitro measurement of intrinsic and Ras GAP-mediated GTP hydrolysis

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.2430

1 reference

10 September 2017

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10 September 2017

1 reference