Targeting the MET receptor tyrosine kinase in non-small cell lung cancer: emerging role of tivantinib (Q38261315)

1 September 2017

1 reference

title

Targeting the MET receptor tyrosine kinase in non-small cell lung cancer: emerging role of tivantinib (English)

1 reference

1 September 2017

1 reference

Eberechi S Agwa

1

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PMCID

4198276

1 September 2017

Patrick C Ma

series ordinal

2

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PMCID

4198276

1 September 2017

language of work or name

English

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publication date

4 October 2014

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Cancer Management and Research

1 September 2017

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1 September 2017

6

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1 September 2017

397-404

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Creative Commons Attribution-NonCommercial 3.0 Unported

1 September 2017

start time

1 October 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Cytotoxic activity of tivantinib (ARQ 197) is not due solely to c-MET inhibition.

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Phase 1 dose-escalation trial evaluating the combination of the selective MET (mesenchymal-epithelial transition factor) inhibitor tivantinib (ARQ 197) plus erlotinib

6 September 2017

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Targeting MET in cancer: rationale and progress

6 September 2017

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MET signaling: novel targeted inhibition and its clinical development in lung cancer

6 September 2017

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Correlation between MET gene copy number by silver in situ hybridization and protein expression by immunohistochemistry in non-small cell lung cancer

6 September 2017

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Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer.

6 September 2017

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Early clinical development of ARQ 197, a selective, non-ATP-competitive inhibitor targeting MET tyrosine kinase for the treatment of advanced cancers.

6 September 2017

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Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification

6 September 2017

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Randomized, double-blind, placebo-controlled, phase II trial of sorafenib and erlotinib or erlotinib alone in previously treated advanced non-small-cell lung cancer

6 September 2017

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Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197

6 September 2017

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MET signalling: principles and functions in development, organ regeneration and cancer

6 September 2017

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MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor

6 September 2017

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Discovery of small molecule c-Met inhibitors: Evolution and profiles of clinical candidates

6 September 2017

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MET, HGF, EGFR, and PXN gene copy number in lung cancer using DNA extracts from FFPE archival samples and prognostic significance

6 September 2017

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MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients.

6 September 2017

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Expression and mutational analysis of MET in human solid cancers

6 September 2017

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MET as a target for treatment of chest tumors

6 September 2017

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Drug development of MET inhibitors: targeting oncogene addiction and expedience

6 September 2017

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MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

6 September 2017

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Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Hepatocyte growth factor: new arsenal in the fights against renal fibrosis?

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Met, metastasis, motility and more

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

c-Met: structure, functions and potential for therapeutic inhibition

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

HGF/SF-met signaling in the control of branching morphogenesis and invasion

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Hepatocyte growth factor: renotropic role and potential therapeutics for renal diseases

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Met receptor tyrosine kinase: enhanced signaling through adapter proteins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Hepatocyte growth factor/scatter factor, its molecular, cellular and clinical implications in cancer

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

6 September 2017

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Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Scatter factor/hepatocyte growth factor is essential for liver development

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

MET gene copy number in non-small cell lung cancer: molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Hepatocyte growth factor gene therapy of liver cirrhosis in rats

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth

23 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Expression of c-met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Population pharmacokinetics of rilotumumab, a fully human monoclonal antibody against hepatocyte growth factor, in cancer patients

23 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Rationale and design of MARQUEE: a phase III, randomized, double-blind study of tivantinib plus erlotinib versus placebo plus erlotinib in previously treated patients with locally advanced or metastatic, nonsquamous, non-small-cell lung cancer.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

c-MET/phospho-MET protein expression and MET gene copy number in non-small cell lung carcinomas.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

High MET gene copy number leads to shorter survival in patients with non-small cell lung cancer.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Hepatocyte growth factor gene transfer to alveolar septa for effective suppression of lung fibrosis.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Differential expression of Met/hepatocyte growth factor receptor in subtypes of non-small cell lung cancers.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198276

Co-expression of theHGF/SF andc-met genes during early mouse embryogenesis precedes reciprocal expression in adjacent tissues during organogenesis

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25328417

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25328417

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A role for HGF/SF in neural induction and its expression in Hensen's node during gastrulation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25328417

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2147/CMAR.S37345

1 reference

1 September 2017

1 reference

1 September 2017

1 reference

PMCID

4198276