Targeting MET in cancer: rationale and progress (Q37978193)

26 August 2017

Targeting MET in cancer: rationale and progress (English)

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26 August 2017

3

Carmen Birchmeier

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26 August 2017

Ermanno Gherardi

1

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26 August 2017

Walter Birchmeier

series ordinal

2

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26 August 2017

George Vande Woude

series ordinal

4

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26 August 2017

language of work or name

English

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publication date

24 January 2012

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26 August 2017

Nature Reviews Cancer

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26 August 2017

12

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26 August 2017

89-103

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26 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/nrc3205

26 August 2017

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cites work

Molecular cloning of a new transforming gene from a chemically transformed human cell line.

1 reference

Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors

31 March 2020

1 reference

Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation

31 March 2020

1 reference

Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor

31 March 2020

1 reference

Purification and subunit structure of hepatocyte growth factor from rat platelets

31 March 2020

1 reference

Molecular cloning and expression of human hepatocyte growth factor

31 March 2020

1 reference

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

31 March 2020

1 reference

Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement

31 March 2020

1 reference

Hepatocytes and scatter factor

31 March 2020

1 reference

Evidence for the identity of human scatter factor and human hepatocyte growth factor

31 March 2020

1 reference

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

31 March 2020

1 reference

Scatter factor/hepatocyte growth factor is essential for liver development

31 March 2020

1 reference

Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

31 March 2020

1 reference

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

31 March 2020

1 reference

Met, metastasis, motility and more

31 March 2020

1 reference

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

31 March 2020

1 reference

Crosstalk in Met receptor oncogenesis

31 March 2020

1 reference

MET signalling: principles and functions in development, organ regeneration and cancer

31 March 2020

1 reference

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

31 March 2020

1 reference

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a

31 March 2020

1 reference

Structural basis of hepatocyte growth factor/scatter factor and MET signalling

31 March 2020

1 reference

Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling

31 March 2020

1 reference

Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA.

31 March 2020

1 reference

Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor

31 March 2020

1 reference

Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor

31 March 2020

1 reference

Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation

31 March 2020

1 reference

Hepsin promotes prostate cancer progression and metastasis

31 March 2020

1 reference

Tumor suppressor activity and epigenetic inactivation of hepatocyte growth factor activator inhibitor type 2/SPINT2 in papillary and clear cell renal cell carcinoma

31 March 2020

1 reference

Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding

31 March 2020

1 reference

Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution

31 March 2020

1 reference

Structural basis for agonism and antagonism of hepatocyte growth factor

31 March 2020

1 reference

Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor

31 March 2020

1 reference

Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB

31 March 2020

1 reference

Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB

31 March 2020

1 reference

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

31 March 2020

1 reference

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase

31 March 2020

1 reference

Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor

31 March 2020

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Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

31 March 2020

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Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo

31 March 2020

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The tyrosine phosphatase Shp2 in development and cancer

31 March 2020

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Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology

31 March 2020

1 reference

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

31 March 2020

1 reference

Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros

31 March 2020

1 reference

Derailed endocytosis: an emerging feature of cancer

31 March 2020

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A direct role for Met endocytosis in tumorigenesis.

31 March 2020

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Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

31 March 2020

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Down-regulation of MET, the receptor for hepatocyte growth factor.

31 March 2020

1 reference

The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

31 March 2020

1 reference

Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation

31 March 2020

1 reference

A novel germ line juxtamembrane Met mutation in human gastric cancer

31 March 2020

1 reference

Gastric cancer cell line Hs746T harbors a splice site mutation of c-Met causing juxtamembrane domain deletion

31 March 2020

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Down-regulation of the met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis

31 March 2020

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Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

31 March 2020

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31 March 2020

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Met provides essential signals for liver regeneration

31 March 2020

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Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair

31 March 2020

1 reference

beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin

31 March 2020

1 reference

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

31 March 2020

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c-Met is essential for wound healing in the skin

31 March 2020

1 reference

Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF.

31 March 2020

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Expression and mutational analysis of MET in human solid cancers

31 March 2020

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Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele

31 March 2020

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Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer

31 March 2020

1 reference

Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas

31 March 2020

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Frequent amplification of the c-met gene in scirrhous type stomach cancer.

31 March 2020

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Karyotypic analysis of gastric carcinoma cell lines carrying an amplified c-met oncogene.

31 March 2020

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Showering c-MET-dependent cancers with drugs

31 March 2020

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Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells

31 March 2020

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HGF converts ErbB2/Neu epithelial morphogenesis to cell invasion

31 March 2020

1 reference

Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells

31 March 2020

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MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

31 March 2020

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Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.

31 March 2020

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MET kinase inhibitor SGX523 synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth

31 March 2020

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The semaphorin 4D receptor controls invasive growth by coupling with Met

31 March 2020

1 reference

Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex

31 March 2020

1 reference

Wnt signalling and its impact on development and cancer

31 March 2020

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Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis

31 March 2020

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Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions

31 March 2020

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TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

31 March 2020

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Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases

31 March 2020

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Regulation of c-Met signaling by the tetraspanin KAI-1/CD82 affects cancer cell migration

31 March 2020

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Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis.

31 March 2020

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Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis

31 March 2020

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Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth

31 March 2020

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Scatter factor induces blood vessel formation in vivo

31 March 2020

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Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation.

31 March 2020

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Cross-talk between the VEGF-A and HGF signalling pathways in endothelial cells.

31 March 2020

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A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts

31 March 2020

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Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth.

31 March 2020

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Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1alpha in human salivary gland cancer cells.

31 March 2020

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Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway

31 March 2020

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Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

31 March 2020

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Increased expression of Met protein is associated with up-regulation of hypoxia inducible factor-1 (HIF-1) in tumour cells in papillary carcinoma of the thyroid.

31 March 2020

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Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases

31 March 2020

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E7050: a dual c-Met and VEGFR-2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft models

31 March 2020

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The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis

31 March 2020

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Role of morphogenetic factors in metastasis of mammary carcinoma cells.

31 March 2020

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Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways.

31 March 2020

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The mutationally activated Met receptor mediates motility and metastasis

31 March 2020

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In vivo direct molecular imaging of early tumorigenesis and malignant progression induced by transgenic expression of GFP-Met

31 March 2020

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A point mutation in the MET oncogene abrogates metastasis without affecting transformation.

31 March 2020

1 reference

Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis

31 March 2020

1 reference

Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells

31 March 2020

1 reference

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

31 March 2020

1 reference

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

31 March 2020

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Tumor growth need not be driven by rare cancer stem cells

31 March 2020

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31 March 2020

12 December 2020

Wnt/beta-catenin signaling in development and disease

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Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling

31 March 2020

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Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells.

31 March 2020

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Wnt signaling in stem and cancer stem cells

31 March 2020

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Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing.

31 March 2020

1 reference

Migration of Bone Marrow and Cord Blood Mesenchymal Stem Cells In Vitro Is Regulated by Stromal-Derived Factor-1-CXCR4 and Hepatocyte Growth Factor-c-met Axes and Involves Matrix Metalloproteinases

31 March 2020

1 reference

Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling

31 March 2020

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Cardiac Stem Cells Possess Growth Factor-Receptor Systems That After Activation Regenerate the Infarcted Myocardium, Improving Ventricular Function and Long-Term Survival

31 March 2020

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HGF/SF is present in normal adult skeletal muscle and is capable of activating satellite cells

31 March 2020

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Identification and differentiation of hepatic stem cells during liver development

31 March 2020

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Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting.

31 March 2020

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Crypt stem cells as the cells-of-origin of intestinal cancer

31 March 2020

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Interaction between human-breast cancer metastasis and bone microenvironment through activated hepatocyte growth factor/Met and beta-catenin/Wnt pathways.

31 March 2020

1 reference

The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients

31 March 2020

1 reference

Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma.

31 March 2020

1 reference

Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B

31 March 2020

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Pegylated kunitz domain inhibitor suppresses hepsin-mediated invasive tumor growth and metastasis

31 March 2020

1 reference

Structural insight into distinct mechanisms of protease inhibition by antibodies

31 March 2020

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Unraveling the allosteric mechanism of serine protease inhibition by an antibody

31 March 2020

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The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1).

31 March 2020

1 reference

Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models

31 March 2020

1 reference

Biochemical characterization of AMG 102: a neutralizing, fully human monoclonal antibody to human and nonhuman primate hepatocyte growth factor

31 March 2020

1 reference

NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo

31 March 2020

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A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist

31 March 2020

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Engineering the NK1 fragment of hepatocyte growth factor/scatter factor as a MET receptor antagonist

31 March 2020

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Disassociation of met-mediated biological responses in vivo: the natural hepatocyte growth factor/scatter factor splice variant NK2 antagonizes growth but facilitates metastasis

31 March 2020

1 reference

HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor

31 March 2020

1 reference

Anti-cancer approach with NK4: Bivalent action and mechanisms

31 March 2020

1 reference

The Sema domain of Met is necessary for receptor dimerization and activation

31 March 2020

1 reference

MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival

31 March 2020

1 reference

Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity

31 March 2020

1 reference

A disintegrin and metalloproteinase-10 (ADAM-10) mediates DN30 antibody-induced shedding of the met surface receptor

31 March 2020

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Monovalency unleashes the full therapeutic potential of the DN-30 anti-Met antibody

31 March 2020

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Discovery of small molecule c-Met inhibitors: Evolution and profiles of clinical candidates

31 March 2020

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Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase

31 March 2020

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Structural Basis for Selective Small Molecule Kinase Inhibition of Activated c-Met

31 March 2020

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SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo

31 March 2020

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Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors.

31 March 2020

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Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily

31 March 2020

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Design, synthesis, and biological evaluation of potent c-Met inhibitors

31 March 2020

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ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity.

31 March 2020

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Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197

31 March 2020

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Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

31 March 2020

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Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia

31 March 2020

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A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings

31 March 2020

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Activation of c-Met (hepatocyte growth factor receptor) in human gastric cancer tissue

31 March 2020

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Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells

31 March 2020

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MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors

31 March 2020

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Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition.

31 March 2020

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Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors

31 March 2020

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International thymic malignancy interest group.

31 March 2020

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Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer

31 March 2020

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Synergistic effects of foretinib with HER-targeted agents in MET and HER1- or HER2-coactivated tumor cells.

31 March 2020

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Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

31 March 2020

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Proteolytic processing of the hepatocyte growth factor/scatter factor receptor by furin

31 March 2020

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Functional map and domain structure of MET, the product of the c- met protooncogene and receptor for hepatocyte growth factor/scatter factor

31 March 2020

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Insights into the structure/function of hepatocyte growth factor/scatter factor from studies with individual domains

31 March 2020

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Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells

31 March 2020

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Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor

31 March 2020

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Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

31 March 2020

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Essential role of Gab1 for signaling by the c-Met receptor in vivo

31 March 2020

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InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase

31 March 2020

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MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis

31 March 2020

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Harvey ras induction of metastatic potential depends upon oncogene activation and the type of recipient cell

31 March 2020

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12 December 2020

Activation of the zymogen of hepatocyte growth factor activator by thrombin

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12 December 2020

XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC.

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12 December 2020

Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes

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12 December 2020

Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer

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12 December 2020

ARQ-197, an oral small-molecule inhibitor of c-Met for the treatment of solid tumors.

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12 December 2020

Gene amplification in gastric and esophageal adenocarcinomas

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12 December 2020

The role of SF/HGF and c-Met in the development of skeletal muscle.

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12 December 2020

Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes.

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12 December 2020

The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas

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12 December 2020

Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers

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12 December 2020

Identifiers

DOI

10.1038/NRC3205

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26 August 2017

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