MET signalling: principles and functions in development, organ regeneration and cancer (Q37811895)

23 August 2017

MET signalling: principles and functions in development, organ regeneration and cancer (English)

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23 August 2017

3

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23 August 2017

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author name string

Livio Trusolino

series ordinal

1

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23 August 2017

1 December 2010

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Nature Reviews Molecular Cell Biology

23 August 2017

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23 August 2017

11

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23 August 2017

834-848

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23 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nrm3012

23 August 2017

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cites work

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Wound repair and regeneration

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Patterning mechanisms of branched organs

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Generation and regeneration of cells of the liver and pancreas

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Cancer as an overhealing wound: an old hypothesis revisited

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Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

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New signals from the invasive front

31 March 2020

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The basics of epithelial-mesenchymal transition

31 March 2020

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Epithelial-mesenchymal transitions in development and disease

31 March 2020

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Mechanism of met oncogene activation

31 March 2020

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Tyrosine kinase receptor indistinguishable from the c-met protein

31 March 2020

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Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

31 March 2020

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Molecular cloning and expression of human hepatocyte growth factor

31 March 2020

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Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

31 March 2020

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Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

31 March 2020

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Evidence for the identity of human scatter factor and human hepatocyte growth factor

31 March 2020

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Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase

31 March 2020

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Met, metastasis, motility and more

31 March 2020

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Drug development of MET inhibitors: targeting oncogene addiction and expedience

31 March 2020

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Scatter-factor and semaphorin receptors: cell signalling for invasive growth

31 March 2020

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Crosstalk in Met receptor oncogenesis

31 March 2020

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Met receptor tyrosine kinase: enhanced signaling through adapter proteins

31 March 2020

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HGF/SF-met signaling in the control of branching morphogenesis and invasion

31 March 2020

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HGF/SF-Met signaling in tumor progression

31 March 2020

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From Tpr-Met to Met, tumorigenesis and tubes.

31 March 2020

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Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development

31 March 2020

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31 March 2020

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Stromal fibroblasts in cancer initiation and progression

31 March 2020

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Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA.

31 March 2020

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A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

31 March 2020

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Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1

31 March 2020

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Contact inhibition of hepatocyte growth regulated by functional association of the c-Met/hepatocyte growth factor receptor and LAR protein-tyrosine phosphatase

31 March 2020

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Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase

31 March 2020

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Tyrosine kinase signal specificity: lessons from the HGF receptor

31 March 2020

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Phosphatidylinositol 3-kinase Contributes to Erk1/Erk2 MAP Kinase Activation Associated with Hepatocyte Growth Factor-induced Cell Scattering

31 March 2020

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The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

31 March 2020

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The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase

31 March 2020

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Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase

31 March 2020

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Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

31 March 2020

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Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis

31 March 2020

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Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

31 March 2020

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Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation

31 March 2020

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Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

31 March 2020

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Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis

31 March 2020

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A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation

31 March 2020

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Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

31 March 2020

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Interactions between growth factor receptors and adhesion molecules: breaking the rules

31 March 2020

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A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth

31 March 2020

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Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis

31 March 2020

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Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth

31 March 2020

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CD44: from adhesion molecules to signalling regulators

31 March 2020

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CD44 is required for two consecutive steps in HGF/c-Met signaling.

31 March 2020

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Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin

31 March 2020

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CD44 Regulates Hepatocyte Growth Factor-mediated Vascular Integrity

31 March 2020

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The semaphorin 4D receptor controls invasive growth by coupling with Met

31 March 2020

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Interplay between scatter factor receptors and B plexins controls invasive growth

31 March 2020

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Sema4D induces angiogenesis through Met recruitment by Plexin B1

31 March 2020

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Semaphorin signaling in cancer cells and in cells of the tumor microenvironment--two sides of a coin

31 March 2020

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Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

31 March 2020

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Negative feedback regulation of Met-dependent invasive growth by Notch

31 March 2020

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Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis.

31 March 2020

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Activation of the JNK pathway is essential for transformation by the Met oncogene

31 March 2020

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A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein

31 March 2020

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Hepatocyte growth factor/scatter factor activates proliferation in melanoma cells through p38 MAPK, ATF-2 and cyclin D1.

31 March 2020

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Hepatocyte growth factor sensitizes human ovarian carcinoma cell lines to paclitaxel and cisplatin

31 March 2020

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p38 MAPK turns hepatocyte growth factor to a death signal that commits ovarian cancer cells to chemotherapy-induced apoptosis

31 March 2020

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NF-kappaB in cancer: from innocent bystander to major culprit

31 March 2020

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Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection

31 March 2020

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Activation of NF-kappaB is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis

31 March 2020

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31 March 2020

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c-Met signalling: spatio-temporal decisions

31 March 2020

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Hepatocyte growth factor induces ERK-dependent paxillin phosphorylation and regulates paxillin-focal adhesion kinase association

31 March 2020

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PKC controls HGF-dependent c-Met traffic, signalling and cell migration.

31 March 2020

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PKC and the control of localized signal dynamics.

31 March 2020

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Protein kinase C controls microtubule-based traffic but not proteasomal degradation of c-Met.

31 March 2020

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Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation.

31 March 2020

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Endocytosis and signalling: intertwining molecular networks

31 March 2020

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Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

31 March 2020

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The met receptor degradation pathway: requirement for Lys48-linked polyubiquitin independent of proteasome activity

31 March 2020

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Down-regulation of MET, the receptor for hepatocyte growth factor.

31 March 2020

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The Listeria protein internalin B mimics hepatocyte growth factor-induced receptor trafficking

31 March 2020

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Molecular ticket to enter cells

31 March 2020

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The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

31 March 2020

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Decorin is a novel antagonistic ligand of the Met receptor

31 March 2020

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Endocytosis conducts the cell signaling orchestra

31 March 2020

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Down-regulation of the met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis

31 March 2020

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C-terminal truncated forms of Met, the hepatocyte growth factor receptor

31 March 2020

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Suramin modulates cellular levels of hepatocyte growth factor receptor by inducing shedding of a soluble form.

31 March 2020

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Vascular origin of a soluble truncated form of the hepatocyte growth factor receptor (c-met).

31 March 2020

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Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity

31 March 2020

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A disintegrin and metalloproteinase-10 (ADAM-10) mediates DN30 antibody-induced shedding of the met surface receptor

31 March 2020

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"Active" cancer immunotherapy by anti-Met antibody gene transfer

31 March 2020

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Monovalency unleashes the full therapeutic potential of the DN-30 anti-Met antibody

31 March 2020

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Targeting the tumor and its microenvironment by a dual-function decoy Met receptor

31 March 2020

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Met decoys: will cancer take the bait?

31 March 2020

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Network biology: understanding the cell's functional organization

31 March 2020

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Scatter factor/hepatocyte growth factor is essential for liver development

31 March 2020

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Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

31 March 2020

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Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

31 March 2020

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Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons.

31 March 2020

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Multiple roles for hepatocyte growth factor in sympathetic neuron development.

31 March 2020

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Met signaling is required for recruitment of motor neurons to PEA3-positive motor pools.

31 March 2020

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Coupling Met to specific pathways results in distinct developmental outcomes

31 March 2020

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Essential role of Gab1 for signaling by the c-Met receptor in vivo

31 March 2020

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Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo

31 March 2020

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Modelling glandular epithelial cancers in three-dimensional cultures

31 March 2020

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How to make tubes: signaling by the Met receptor tyrosine kinase

31 March 2020

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ERK and MMPs sequentially regulate distinct stages of epithelial tubule development

31 March 2020

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Making tubes: step by step

31 March 2020

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Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesis

31 March 2020

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Involvement of matrix metalloproteinase type-3 in hepatocyte growth factor-induced invasion of human hepatocellular carcinoma cells

31 March 2020

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Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor

31 March 2020

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Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair

31 March 2020

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Met provides essential signals for liver regeneration

31 March 2020

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Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection

31 March 2020

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Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action

31 March 2020

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Cellular and molecular mechanisms of fibrosis

31 March 2020

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Hepatocyte growth factor gene therapy of liver cirrhosis in rats

31 March 2020

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Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction

31 March 2020

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Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF

31 March 2020

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Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis.

31 March 2020

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Epidermal homeostasis: a balancing act of stem cells in the skin

31 March 2020

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c-Met is essential for wound healing in the skin

31 March 2020

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Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

31 March 2020

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A point mutation in the MET oncogene abrogates metastasis without affecting transformation.

31 March 2020

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Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis.

31 March 2020

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Downstream signalling and specific inhibition of c-MET/HGF pathway in small cell lung cancer: implications for tumour invasion

31 March 2020

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Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

31 March 2020

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MET mutations in cancers of unknown primary origin (CUPs).

31 March 2020

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Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752

31 March 2020

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Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling

31 March 2020

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Signaling networks assembled by oncogenic EGFR and c-Met

31 March 2020

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Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction

31 March 2020

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Inhibition of Src impairs the growth of met-addicted gastric tumors.

31 March 2020

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A module of negative feedback regulators defines growth factor signaling

31 March 2020

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Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses.

31 March 2020

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MicroRNA miR-199a* regulates the MET proto-oncogene and the downstream extracellular signal-regulated kinase 2 (ERK2)

31 March 2020

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MicroRNAs impair MET-mediated invasive growth

31 March 2020

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miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation

31 March 2020

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MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells

31 March 2020

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A two-pronged approach to the clinical use of HGF

31 March 2020

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A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of Met

31 March 2020

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Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor

31 March 2020

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Tumor cytotoxic factor/hepatocyte growth factor from human fibroblasts: cloning of its cDNA, purification and characterization of recombinant protein

31 March 2020

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Hepatocyte growth factor induces pro-apoptotic genes in HepG2 hepatoma but not in B16-F1 melanoma cells

31 March 2020

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HGF reduces advancing lung fibrosis in mice: a potential role for MMP-dependent myofibroblast apoptosis.

31 March 2020

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Hepatocyte growth factor-activated NF-kappaB regulates HIF-1 activity and ODC expression, implicated in survival, differently in different carcinoma cell lines.

31 March 2020

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A mechanism of cell survival: sequestration of Fas by the HGF receptor Met.

31 March 2020

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Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage

31 March 2020

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Amplification of apoptosis through sequential caspase cleavage of the MET tyrosine kinase receptor

31 March 2020

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Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly

31 March 2020

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c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells

31 March 2020

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Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase.

31 March 2020

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Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway

31 March 2020

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Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

31 March 2020

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Front-cell-specific expression of membrane-type 1 matrix metalloproteinase and gelatinase A during cohort migration of colon carcinoma cells induced by hepatocyte growth factor/scatter factor

31 March 2020

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12 December 2020

Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA.

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12 December 2020

Shedding of c-Met is regulated by crosstalk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive metalloproteinase.

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12 December 2020

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor

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12 December 2020

The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation

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12 December 2020

Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein

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12 December 2020

Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET

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12 December 2020

Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways

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12 December 2020

Role of the plasminogen activator and matrix metalloproteinase systems in epidermal growth factor- and scatter factor-stimulated invasion of carcinoma cells

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12 December 2020

Interaction of hepatocyte growth factor with heparan sulfate. Elucidation of the major heparan sulfate structural determinants

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12 December 2020

The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein

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12 December 2020

Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes.

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12 December 2020

Hepatocyte growth factor specifically binds to sulfoglycolipids

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12 December 2020

Identifiers

DOI

10.1038/NRM3012

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23 August 2017

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PubMed ID

21102609