Met, metastasis, motility and more (Q28235183)

Nature Reviews Molecular Cell Biology

Europe PubMed Central

title

Met, metastasis, motility and more (English)

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Carmen Birchmeier

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author name string

Walter Birchmeier

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2

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Ermanno Gherardi

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3

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George F Vande Woude

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4

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language of work or name

English

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publication date

December 2003

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published in

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volume

4

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page(s)

915-25

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issue

12

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cites work

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Mechanism of met oncogene activation

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Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

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Molecular cloning and expression of human hepatocyte growth factor

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Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor

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Evidence for the identity of human scatter factor and human hepatocyte growth factor

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Hepatocytes and scatter factor

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Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

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Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP)

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Functional map and domain structure of MET, the product of the c- met protooncogene and receptor for hepatocyte growth factor/scatter factor

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A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

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Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

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Essential role of Gab1 for signaling by the c-Met receptor in vivo

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Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

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Scatter factor/hepatocyte growth factor is essential for liver development

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Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

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Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

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Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

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Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2.

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Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo

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Structure of a heparin-linked biologically active dimer of fibroblast growth factor

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Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution

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Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding

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Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor.

31 March 2020

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Mutational analysis and molecular modeling of the N-terminal kringle-containing domain of hepatocyte growth factor identifies amino acid side chains important for interaction with the c-Met receptor

31 March 2020

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Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

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DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.

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The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction

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Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

31 March 2020

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Src homology 2-containing inositol 5-phosphatase 1 binds to the multifunctional docking site of c-Met and potentiates hepatocyte growth factor-induced branching tubulogenesis.

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Motogenic and morphogenic activity of epithelial receptor tyrosine kinases

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The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

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Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

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The "Gab" in signal transduction.

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How to make tubes: signaling by the Met receptor tyrosine kinase

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Regulation of the mitogen-activated protein kinase signaling pathway by SHP2.

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Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway

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Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

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Down-regulation of MET, the receptor for hepatocyte growth factor.

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Epithelial-mesenchymal transitions in tumour progression

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Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells

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Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly

31 March 2020

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Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells

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Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway

31 March 2020

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Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway

31 March 2020

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Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation

31 March 2020

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Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

31 March 2020

1 reference

A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein

31 March 2020

1 reference

The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair

31 March 2020

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Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation

31 March 2020

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Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

31 March 2020

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Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis

31 March 2020

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Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes

31 March 2020

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Activation of NF-kappaB is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis

31 March 2020

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Regulation of epithelial cell migration and tumor formation by beta-catenin signaling

31 March 2020

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CD44 is required for two consecutive steps in HGF/c-Met signaling.

31 March 2020

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The semaphorin 4D receptor controls invasive growth by coupling with Met

31 March 2020

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A mechanism of cell survival: sequestration of Fas by the HGF receptor Met.

31 March 2020

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A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth

31 March 2020

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Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells

31 March 2020

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Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival

31 March 2020

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Evolutionary origins of vertebrate appendicular muscle.

31 March 2020

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Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

31 March 2020

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Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development

31 March 2020

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Hepatocyte growth factor, a versatile signal for developing neurons

31 March 2020

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31 March 2020

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Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF.

31 March 2020

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Early treatment with hepatocyte growth factor improves cardiac function in experimental heart failure induced by myocardial infarction

31 March 2020

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Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation

31 March 2020

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In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis.

31 March 2020

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Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor

31 March 2020

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Dysregulation of Met receptor tyrosine kinase activity in invasive tumors

31 March 2020

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Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice

31 March 2020

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Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase

31 March 2020

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Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells

31 March 2020

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Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers

31 March 2020

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The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma.

31 March 2020

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Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo

31 March 2020

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K252a inhibits the oncogenic properties of Met, the HGF receptor

31 March 2020

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Potent blockade of hepatocyte growth factor-stimulated cell motility, matrix invasion and branching morphogenesis by antagonists of Grb2 Src homology 2 domain interactions

31 March 2020

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Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models

31 March 2020

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NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells

31 March 2020

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Receptor tyrosine kinases as therapeutic targets: the model of the MET oncogene.

31 March 2020

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Smart drugs: tyrosine kinase inhibitors in cancer therapy

31 March 2020

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Small molecule tyrosine kinase inhibitors: clinical development of anticancer agents

31 March 2020

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Perspectives on the development of a molecularly targeted agent

31 March 2020

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

31 March 2020

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Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis.

31 March 2020

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A gene-expression signature as a predictor of survival in breast cancer

31 March 2020

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Radioimmunoscintigraphy of tumors autocrine for human met and hepatocyte growth factor/scatter factor

31 March 2020

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Activating mutations for the met tyrosine kinase receptor in human cancer

31 March 2020

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

31 March 2020

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Structural basis of oncogenic activation caused by point mutations in the kinase domain of the MET proto-oncogene: modeling studies

31 March 2020

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Genes that control the development of migrating muscle precursor cells.

31 March 2020

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