Drug development of MET inhibitors: targeting oncogene addiction and expedience (Q34782774)

4 August 2017

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title

Drug development of MET inhibitors: targeting oncogene addiction and expedience (English)

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4 August 2017

Silvia Giordano

2

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Paolo M. Comoglio

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Paolo M Comoglio

series ordinal

1

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author name string

Livio Trusolino

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3

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4 August 2017

1 June 2008

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Nature Reviews Drug Discovery

4 August 2017

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4 August 2017

7

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4 August 2017

504-516

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4 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/nrd2530

4 August 2017

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K252a inhibits the oncogenic properties of Met, the HGF receptor

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The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants

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31 March 2020

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CD44 is required for two consecutive steps in HGF/c-Met signaling.

31 March 2020

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The semaphorin 4D receptor controls invasive growth by coupling with Met

31 March 2020

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Interplay between scatter factor receptors and B plexins controls invasive growth

31 March 2020

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Sema4D induces angiogenesis through Met recruitment by Plexin B1

31 March 2020

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Expression of Met protein in thyroid tumours

31 March 2020

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Overexpression of c-Met protein in human thyroid tumors correlated with lymph node metastasis and clinicopathologic stage

31 March 2020

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31 March 2020

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31 March 2020

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Expression of hepatocyte growth factor and its receptor, the c-met proto-oncogene, in hepatocellular carcinoma

31 March 2020

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u-PA and c-MET mRNA expression is co-ordinately enhanced while hepatocyte growth factor mRNA is down-regulated in human hepatocellular carcinoma

31 March 2020

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Met expression is associated with poor outcome in patients with axillary lymph node negative breast carcinoma

31 March 2020

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Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer

31 March 2020

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MET receptor is overexpressed but not mutated in oral squamous cell carcinomas.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD2530

1 reference

4 August 2017

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PubMed ID

18511928