A proposed framework for assessing risk from less-than-lifetime exposures to carcinogens (Q37876891)

24 August 2017

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title

A proposed framework for assessing risk from less-than-lifetime exposures to carcinogens (English)

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24 August 2017

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14

R Julian Preston

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24 August 2017

Susan P Felter

1

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24 August 2017

Rory B Conolly

2

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24 August 2017

Joel P Bercu

3

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24 August 2017

P Michael Bolger

4

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24 August 2017

Alan R Boobis

5

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24 August 2017

Peter M J Bos

6

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24 August 2017

Philip Carthew

7

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24 August 2017

Nancy G Doerrer

8

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24 August 2017

Jay I Goodman

9

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24 August 2017

Wafa A Harrouk

10

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24 August 2017

David J Kirkland

11

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24 August 2017

Serrine S Lau

12

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24 August 2017

G Craig Llewellyn

13

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24 August 2017

Rita Schoeny

15

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24 August 2017

A Robert Schnatter

16

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24 August 2017

Angelika Tritscher

17

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24 August 2017

Frans van Velsen

18

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24 August 2017

Gary M Williams

19

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24 August 2017

language of work or name

English

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publication date

18 May 2011

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Critical Reviews in Toxicology

24 August 2017

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24 August 2017

41

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24 August 2017

507-544

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24 August 2017

6

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Carcinogens are mutagens: their detection and classification

24 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

The causes and prevention of cancer: gaining perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Critical windows of exposure for children's health: cancer in human epidemiological studies and neoplasms in experimental animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

The age distribution of cancer and a multi-stage theory of carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Carcinogenesis in mouse and human cells: parallels and paradoxes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Assessing susceptibility from early-life exposure to carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Predictive models for carcinogenicity and mutagenicity: frameworks, state-of-the-art, and perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: aflatoxin B1 (AFB1).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

In silico approaches to predicting cancer potency for risk assessment of genotoxic impurities in drug substances

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Cancer and developmental exposure to endocrine disruptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

IPCS framework for analyzing the relevance of a cancer mode of action for humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Application of key events analysis to chemical carcinogens and noncarcinogens

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Risk assessment of peak exposure to genotoxic carcinogens: a pragmatic approach

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.552063

A comprehensive approach for integration of toxicity and cancer risk assessments

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.552063

The Single Exposure Carcinogen Database: assessing the circumstances under which a single exposure to a carcinogen can cause cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Mechanistic data and risk assessment of selected toxic end points of the thyroid gland

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

DNA damage as assessed by 32P-postlabelling in three rat strains exposed to dietary tamoxifen: the relationship between cell proliferation and liver tumour formation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

A tiered approach to threshold of regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Using the Biological Two-Stage Model to Assess Risk from Short-Term Exposures

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Evaluating the human relevance of chemically induced animal tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Lymphohaematopoeitic cancer mortality among workers with benzene exposure

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Estimation of toxic hazard—A decision tree approach

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.552063

The cumulative risk of lung cancer among current, ex- and never-smokers in European men.

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.552063

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.552063

A new method for determining allowable daily intakes.

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.552063

What role for biologically based dose-response models in estimating low-dose risk?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Prevention of breast cancer in postmenopausal women: approaches to estimating and reducing risk

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

The effect of age and exposure duration on cancer induction by a known carcinogen in rats, mice, and hamsters.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Cancer epigenomics: DNA methylomes and histone-modification maps

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Evaluation of child/adult pharmacokinetic differences from a database derived from the therapeutic drug literature.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Extending the threshold of regulation concept: de minimis limits for carcinogens and mutagens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Neonatal mouse assay for tumorigenicity: alternative to the chronic rodent bioassay.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Effects of hypochlorhydria and hypergastrinemia on structure and function of gastrointestinal cells. A review and analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Evaluation of the newborn mouse model for chemical tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

The carcinogenesis bioassay in perspective: application in identifying human cancer hazards

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.552063

The use of Haber's law in standard setting and risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Quick estimate of the regulatory virtually safe dose based on the maximum tolerated dose for rodent bioassays.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Regulatory cancer risk assessment based on a quick estimate of a benchmark dose derived from the maximum tolerated dose.

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Uncertainty in cancer risk estimates.

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.552063

A carcinogenic potency database of the standardized results of animal bioassays

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

The Carcinogenic Potency Database: analyses of 4000 chronic animal cancer experiments published in the general literature and by the U.S. National Cancer Institute/National Toxicology Program

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Rodent carcinogens: setting priorities

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Supplement to the Carcinogenic Potency Database (CPDB): results of animal bioassays published in the general literature in 1993 to 1994 and by the National Toxicology Program in 1995 to 1996.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Supplement to the Carcinogenic Potency Database (CPDB): results of animal bioassays published in the general literature through 1997 and by the National Toxicology Program in 1997-1998.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Altered DNA methylation: a secondary mechanism involved in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Proposed mechanism of induction of gastric carcinoids: the gastrin hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

13th Meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC): alternative testing methodologies for organ toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Cancer induction following single and multiple exposures to a constant amount of vinyl chloride monomer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Development of the murine and human immune system: differential effects of immunotoxicants depend on time of exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Species comparison of anatomical and functional immune system development

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.552063

DNA mismatch repair: molecular mechanism, cancer, and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Use of genotoxicity data to support clinical trials or positive genetox findings on a candidate pharmaceutical or impurity .... now what?

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Nasal cytotoxic and carcinogenic activities of systemically distributed organic chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Effect of varying exposure regimens on methylene chloride-induced lung and liver tumors in female B6C3F1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Using average lifetime dose rate for intermittent exposures to carcinogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Promotion of hepatocarcinogenesis in humans and animal models

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Organ and cell specificity of base excision repair mutants in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Exposure to beryllium and occurrence of lung cancer: a reexamination of findings from a nested case-control study.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Drug-like properties and the causes of poor solubility and poor permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Trichloroethylene: mechanisms of renal toxicity and renal cancer and relevance to risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

The context and potential of epigenetics in oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

The Viracept (nelfinavir)--ethyl methanesulfonate case: a threshold risk assessment for human exposure to a genotoxic drug contamination?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Finding the missing heritability of complex diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Neonatal mouse model: review of methods and results

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Formaldehyde and glutaraldehyde and nasal cytotoxicity: case study within the context of the 2006 IPCS Human Framework for the Analysis of a cancer mode of action for humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

A framework for human relevance analysis of information on carcinogenic modes of action

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Guidelines for application of chemical-specific adjustment factors in dose/concentration-response assessment.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Haber's rule: a special case in a family of curves relating concentration and duration of exposure to a fixed level of response for a given endpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Differences between children and adults: implications for risk assessment at California EPA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Mortality and cancer incidence following occupational radiation exposure: third analysis of the National Registry for Radiation Workers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Ethyl methanesulfonate toxicity in Viracept--a comprehensive human risk assessment based on threshold data for genotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

A procedure for the safety evaluation of flavouring substances. Joint FAO/WHO Expert Committee on Food Additives

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Carcinogenic risk assessment with time-dependent exposure patterns.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Cancer risk assessment with intermittent exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Genome instability and DNA damage accumulation in gene-targeted mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Are genotoxic carcinogens more potent than nongenotoxic carcinogens?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

An evaluation of the implementation of the Cramer classification scheme in the Toxtree software

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Reevaluation of benzene exposure for the Pliofilm (rubberworker) cohort (1936-1976).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Association of long lasting unsurmountable histamine H2 blockade and gastric carcinoid tumours in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Solid cancer incidence in atomic bomb survivors: 1958-1998

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Temporal variation in the association between benzene and leukemia mortality

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Dose and time as variables of toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

The role of time in toxicology or Haber's c x t product

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Lung cancer case control study of beryllium workers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Comparison of carcinogenic and in vivo genotoxic potency estimates.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Calculation of carcinogenic potency from long-term animal carcinogenesis experiments.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Differential sensitivity of children and adults to chemical toxicity. I. Biological basis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Adjustment for temporal confounders in a reanalysis of a case-control study of beryllium and lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity data

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Dose-dependent transitions in mechanisms of toxicity: case studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

N-ethyl-N-nitrosourea (ENU) increased brain mutations in prenatal and neonatal mice but not in the adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Hormonal carcinogenesis and socio-biological development factors in endometrial cancer: a clinical review

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Prediction of cancer potency using a battery of mutation and toxicity data

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Development of quantitative structure-activity relationship (QSAR) models to predict the carcinogenic potency of chemicals I. Alternative toxicity measures as an estimator of carcinogenic potency

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Cancer genes and the pathways they control

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Decrease in risk of lung cancer death in males after smoking cessation by age at quitting: findings from the JACC study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Alteration of liver cell function and proliferation: differentiation between adaptation and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Evaluation of potential human carcinogenicity of the synthetic monomer ethyl acrylate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Mechanistic basis for nonlinearities and thresholds in rat liver carcinogenesis by the DNA-reactive carcinogens 2-acetylaminofluorene and diethylnitrosamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Thresholds for the effects of 2-acetylaminofluorene in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

A framework for using structural, reactivity, metabolic and physicochemical similarity to evaluate the suitability of analogs for SAR-based toxicological assessments.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Generation, biological consequences and repair mechanisms of cytosine deamination in DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

Structural motifs modulating the carcinogenic risk of aromatic amines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.552063

10.3109/10408444.2011.552063

21 January 2018

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DOI

1 reference

24 August 2017

1 reference