A framework for human relevance analysis of information on carcinogenic modes of action (Q35631055)

9 August 2017

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title

A framework for human relevance analysis of information on carcinogenic modes of action (English)

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9 August 2017

M E Bette Meek

1

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9 August 2017

John R Bucher

2

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9 August 2017

Samuel M Cohen

3

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9 August 2017

Vicki Dellarco

4

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9 August 2017

Richard N Hill

5

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9 August 2017

Lois D Lehman-McKeeman

6

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9 August 2017

David G Longfellow

7

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9 August 2017

Timothy Pastoor

8

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9 August 2017

Jennifer Seed

9

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9 August 2017

Dorothy E Patton

10

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9 August 2017

language of work or name

English

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publication date

1 January 2003

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Critical Reviews in Toxicology

9 August 2017

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9 August 2017

33

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9 August 2017

591-653

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9 August 2017

6

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Chemical carcinogenesis: too many rodent carcinogens

9 August 2017

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Cytochrome P450 4A and 2E1 expression in human kidney microsomes

21 January 2018

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Cytological Changes due to Urinary Calculi: A Consideration of the Relationship between Calculi and the Development of Urothelial Carcinoma

21 January 2018

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Evaluation of some biomonitoring markers in occupationally exposed populations to acrylonitrile.

21 January 2018

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Assessment of binding of 2,4,4-trimethyl-2-pentanol to low-molecular-weight proteins isolated from kidneys of male rats and humans.

21 January 2018

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Biochemical Mechanisms and Pathobiology of α2u-Globulin Nephropathy

21 January 2018

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Induction of cytochromes P450IIE1 and P450IIB1 by secondary ketones and the role of P450IIE1 in chloroform metabolism

21 January 2018

1 reference

In vivo and in vitro kinetics of ethylene oxide metabolism in rats and mice.

21 January 2018

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An assessment of the genetic toxicity of atrazine: relevance to human health and environmental effects.

21 January 2018

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Human bladder cancer: evidence for a potential irritation-induced mechanism

21 January 2018

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Effects of stones and other physical factors on the induction of rodent bladder cancer

21 January 2018

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Chloroform toxicity in the mouse: Role of genetic factors and steroids

21 January 2018

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Role of urinary physiology and chemistry in bladder carcinogenesis

21 January 2018

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Cell proliferation in carcinogenesis

21 January 2018

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Failure of chloro-S-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro

21 January 2018

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Metabolism of Chloroform by Cytochrome P450 2E1 Is Required for Induction of Toxicity in the Liver, Kidney, and Nose of Male Mice

21 January 2018

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Development of a physiologically based pharmacokinetic model for chloroform

21 January 2018

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Biotransformation of chloroform by rat and human liver microsomes; in vitro effect on some enzyme activities and mechanism of irreversible binding to macromolecules

21 January 2018

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The effect of hepatic enzyme-inducing drugs on thyroid hormones and the thyroid gland

21 January 2018

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The rat as model for the study of drug effects on thyroid function: Consideration of methodological problems

21 January 2018

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Carcinogenicity of ethylene oxide and 1,2-propylene oxide upon intragastric administration to rats

21 January 2018

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In vivo interactions of acrylonitrile with macromolecules in rats

21 January 2018

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A physiologically based pharmacokinetic model for ethylene oxide in mouse, rat, and human

21 January 2018

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Urinary metabolites of [1,2,3-13C]acrylonitrile in rats and mice detected by 13C nuclear magnetic resonance spectroscopy.

21 January 2018

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The closed chamber technique--uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors

21 January 2018

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Structure and sequence relationships in the lipocalins and related proteins

21 January 2018

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Genotoxic risk for humans due to work place exposure to ethylene oxide: remarkable individual differences in susceptibility.

21 January 2018

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A physiologically based dosimetry description of acrylonitrile and cyanoethylene oxide in the rat.

21 January 2018

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Frequency, size and location of brain tumours in F-344 rats chronically exposed to ethylene oxide.

21 January 2018

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Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

21 January 2018

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Cancer incidence in Swedish sterilant workers exposed to ethylene oxide

21 January 2018

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Evidence that the androgen receptor mediates sexual differentiation of mouse renal cytochrome P450 expression

21 January 2018

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Frequency of urolithiasis in a prepaid medical care program

21 January 2018

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Urine cytology in patients with calculi

21 January 2018

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Differential effects of microsomal enzyme inducers on in vitro thyroxine (T(4)) and triiodothyronine (T(3)) glucuronidation

21 January 2018

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Chloroform toxicity in mice: correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules.

21 January 2018

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Transcriptional control of CYP2E1 in the perivenous liver region and during starvation.

21 January 2018

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Carcinogenicity of chloroform in drinking water to male Osborne-Mendel rats and female B6C3F1 mice.

21 January 2018

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The effect of time on the incidence of carcinomas obtained by the implantation of paraffin wax pellets into mouse bladder

21 January 2018

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Uracil-induced urolithiasis in the urinary bladder of rats is irritation-dependent

21 January 2018

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The effect of acrylonitrile on gap junctional intercellular communication in rat astrocytes

21 January 2018

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Induction of oxidative stress and oxidative damage in rat glial cells by acrylonitrile

21 January 2018

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Species differences in the hydrolysis of 2-cyanoethylene oxide, the epoxide metabolite of acrylonitrile.

21 January 2018

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Dose-dependent urinary excretion of acrylonitrile metabolites by rats and mice.

21 January 2018

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Rodent tissue distribution of 2-cyanoethylene oxide, the epoxide metabolite of acrylonitrile.

21 January 2018

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Refinement and verification of the physiologically based dosimetry description for acrylonitrile in rats.

21 January 2018

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Induction of rat liver microsomal epoxide hydrolase by thiazole and pyrazine: hydrolysis of 2-cyanoethylene oxide.

21 January 2018

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A physiologically based description of ethylene oxide dosimetry in the rat

21 January 2018

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Biochemical basis for mouse resistance to hyaline droplet nephropathy: lack of relevance of the alpha 2u-globulin protein superfamily in this male rat-specific syndrome

21 January 2018

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d-Limonene induced hyaline droplet nephropathy in alpha 2u-globulin transgenic mice

21 January 2018

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Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 rats

21 January 2018

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Metabolism, disposition and excretion of [14C]melamine in male Fischer 344 rats

21 January 2018

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Mortality from tumours in workers in an acrylic fibre factory

21 January 2018

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Comparative aspects of contraceptive steroids: effects observed in rats

21 January 2018

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Regenerative hyperplasia is not required for liver tumor induction in female B6C3F1 mice exposed to trihalomethanes.

21 January 2018

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Tissue specific regulation of renal n-nitrosodimethylamine-demethylase activity by testosterone in BALB/c mice

21 January 2018

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Toxicological significance of DNA adducts: summary of discussions with an expert panel

21 January 2018

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Cancer incidence in a group of workers potentially exposed to ethylene oxide

21 January 2018

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Urinary bladder carcinogenesis induced by melamine in F344 male rats: correlation between carcinogenicity and urolith formation.

21 January 2018

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The effect of antipyrine, phenobarbitol and rifampicin on thyroid hormone metabolism in man.

21 January 2018

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A link between liver microsomal enzyme activity and thyroid hormone metabolism in man

21 January 2018

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Mortality from pancreatic and lymphopoietic cancer among workers in ethylene and propylene chlorohydrin production

21 January 2018

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Dosimetry of ethylene oxide in the rat by quantitation of alkylated histidine in hemoglobin

21 January 2018

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Reversibility and apoptosis in rat urinary bladder papillomatosis induced by uracil

21 January 2018

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Epithelial tumours of the lower urinary tract in humans and rodents

21 January 2018

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The role of the central nervous system in the control of ovarian function in higher primates

21 January 2018

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DNA-protein cross-links and sister chromatid exchange frequencies in lymphocytes and hydroxyethyl mercapturic acid in urine of ethylene oxide-exposed hospital workers.

21 January 2018

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Cytogenetic effects of ethylene oxide, with an emphasis on population monitoring

21 January 2018

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A review of epidemiologic studies of triazine herbicides and cancer

21 January 2018

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First Geoffrey Harris Memorial Lecture. Some Recent Developments in Brain-Pituitary-Ovarian Physiology

21 January 2018

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Molecular, cytogenetic, and hematologic effects of ethylene oxide on female hospital workers

21 January 2018

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Reaction products in hemoglobin and DNA after in vitro treatment with ethylene oxide and N-(2-hydroxyethyl)-N-nitrosourea.

21 January 2018

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Blockade of Steroid-Induced Luteinizing Hormone Release by Selective Depletion of Anterior Hypothalamic Norepinephrine Activity*

21 January 2018

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Changes in Hypothalamic NE and DA Turnover Resulting from Steroid-Induced LH and Prolactin Surges in Ovariectomized Rats1

21 January 2018

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Assessment of the in vivo mutagenicity of ethylene oxide in the tissues of B6C3F1 lacI transgenic mice following inhalation exposure.

21 January 2018

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Mechanism of chloroform nephrotoxicity. III. Renal and hepatic microsomal metabolism of chloroform in mice

21 January 2018

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A two-year inhalation study of the carcinogenic potential of ethylene oxide in Fischer 344 rats.

21 January 2018

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DNA adducts of propylene oxide and acrylonitrile epoxide: hydrolytic deamination of 3-alkyl-dCyd to 3-alkyl-dUrd

21 January 2018

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In vitro alkylation of calf thymus DNA by acrylonitrile. Isolation of cyanoethyl-adducts of guanine and thymine and carboxyethyl-adducts of adenine and cytosine

21 January 2018

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In vitro reactions of 2-cyanoethylene oxide with calf thymus DNA.

21 January 2018

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IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis

21 January 2018

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Exposure-response analysis of cancer mortality in a cohort of workers exposed to ethylene oxide

21 January 2018

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A 90-day chloroform inhalation study in F-344 rats: profile of toxicity and relevance to cancer studies.

21 January 2018

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Chloroform-induced cytotoxicity and regenerative cell proliferation in the kidneys and liver of BDF1 mice

21 January 2018

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The inhibition of estrogen receptor-mediated responses by chloro-S-triazine-derived compounds is dependent on estradiol concentration in yeast

21 January 2018

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Correlations of in vitro and in vivo hepatotoxicity for five haloalkanes

21 January 2018

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Increased biliary excretion of thyroxine by microsomal enzyme inducers

21 January 2018

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Effect of microsomal enzyme inducers on the biliary excretion of triiodothyronine (T(3)) and its metabolites

21 January 2018

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In vivo mutagenicity of ethylene oxide at the hprt locus in T-lymphocytes of B6C3F1 lacI transgenic mice following inhalation exposure.

21 January 2018

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Biomarkers of exposure and effect as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide.

21 January 2018

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Phenobarbital induction of cytochrome P-450 gene expression

21 January 2018

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Positive feedback of oestrogen on LH secretion in women in neuroleptic drugs

21 January 2018

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Human skin in vitro percutaneous absorption of gaseous ethylene oxide from fabric

21 January 2018

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Formation of 8-oxodeoxyguanosine in brain DNA of rats exposed to acrylonitrile.

21 January 2018

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Molecular dosimetry of endogenous and ethylene oxide-induced N7-(2-hydroxyethyl) guanine formation in tissues of rodents.

21 January 2018

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Characterization of an adduct and its degradation product produced by the reaction of cyanoethylene oxide with deoxythymidine and DNA.

21 January 2018

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Characterization of phosphodiester adducts produced by the reaction of cyanoethylene oxide with nucleotides.

21 January 2018

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Mechanisms for the induction of oxidative stress in Syrian hamster embryo cells by acrylonitrile

21 January 2018

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21 January 2018

Identifiers

DOI

10.1080/713608373

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9 August 2017

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