In silico approaches to predicting cancer potency for risk assessment of genotoxic impurities in drug substances (Q39886219)

15 September 2017

In silico approaches to predicting cancer potency for risk assessment of genotoxic impurities in drug substances (English)

1 reference

15 September 2017

1 reference

Joel P Bercu

1

1 reference

15 September 2017

Stuart M Morton

2

1 reference

15 September 2017

J Thom Deahl

3

1 reference

15 September 2017

Vijay K Gombar

4

1 reference

15 September 2017

Courtney M Callis

5

1 reference

15 September 2017

Robert B L van Lier

6

1 reference

15 September 2017

language of work or name

English

0 references

publication date

2 April 2010

1 reference

Regulatory Toxicology and Pharmacology

15 September 2017

1 reference

15 September 2017

57

1 reference

15 September 2017

2-3

1 reference

15 September 2017

300-306

1 reference

Risk assessment of substances that are both genotoxic and carcinogenic report of an International Conference organized by EFSA and WHO with support of ILSI Europe.

15 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Toxicological and clinical computational analysis and the US FDA/CDER.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Application of the threshold of toxicological concern approach to ingredients in personal and household care products

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

An impact analysis of the application of the threshold of toxicological concern concept to pharmaceuticals.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

The application of structure-based assessment to support safety and chemistry diligence to manage genotoxic impurities in active pharmaceutical ingredients during drug development.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Uncertainty in cancer risk estimates.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Quick estimate of the regulatory virtually safe dose based on the maximum tolerated dose for rodent bioassays.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Supplement to the Carcinogenic Potency Database (CPDB): results of animal bioassays published in the general literature in 1993 to 1994 and by the National Toxicology Program in 1995 to 1996.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Supplement to the Carcinogenic Potency Database (CPDB): results of animal bioassays published in the general literature through 1997 and by the National Toxicology Program in 1997-1998.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

A carcinogenic potency database of the standardized results of animal bioassays

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

The Carcinogenic Potency Database: analyses of 4000 chronic animal cancer experiments published in the general literature and by the U.S. National Cancer Institute/National Toxicology Program

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Rodent carcinogens: setting priorities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Predicting P-glycoprotein substrates by a quantitative structure-activity relationship model.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

In silico assessment of chemical mutagenesis in comparison with results of Salmonella microsome assay on 909 chemicals.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Recent developments in the risk assessment of potentially genotoxic impurities in pharmaceutical drug substances

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Quantitative factors in chemical carcinogenesis: variation in carcinogenic potency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Threshold of toxicological concern (TTC) in food safety assessment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Drug-like properties and the causes of poor solubility and poor permeability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

In silico approaches to explore toxicity end points: issues and concerns for estimating human health effects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action-Based Predictions of Chemical Carcinogenesis in Rodents.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: II. Identification of genotoxicants, reprotoxicants, and carcinogens using in silico methods

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Structure-activity relationship analysis tools: validation and applicability in predicting carcinogens.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

A procedure for the safety evaluation of flavouring substances. Joint FAO/WHO Expert Committee on Food Additives

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Calculation of carcinogenic potency from long-term animal carcinogenesis experiments.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Development of quantitative structure-activity relationship (QSAR) models to predict the carcinogenic potency of chemicals I. Alternative toxicity measures as an estimator of carcinogenic potency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

Three new consensus QSAR models for the prediction of Ames genotoxicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

A multiple in silico program approach for the prediction of mutagenicity from chemical structure.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2010.03.010

10.1016/J.YRTPH.2010.03.010

7 January 2021

Identifiers

DOI

1 reference

15 September 2017

1 reference