Huntington's disease and Group I metabotropic glutamate receptors (Q37820343)

23 August 2017

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title

Huntington's disease and Group I metabotropic glutamate receptors (English)

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23 August 2017

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1

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23 August 2017

Rita G W Pires

2

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PubMed ID

21153060

23 August 2017

Stephen S G Ferguson

series ordinal

3

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PubMed ID

21153060

23 August 2017

language of work or name

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9 December 2010

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23 August 2017

Molecular Neurobiology

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23 August 2017

43

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23 August 2017

1

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23 August 2017

1-11

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https://scigraph.springernature.com/pub.10.1007/s12035-010-8153-1

23 August 2017

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Regulation of proteins affecting NMDA receptor-induced excitotoxicity in a Huntington's mouse model

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Huntington's disease: a synaptopathy?

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Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease

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Clinical and neuropathologic assessment of severity in Huntington's disease

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Excitotoxic injury of the neostriatum: a model for Huntington's disease

21 January 2018

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Metabotropic glutamate receptors and cell-type-specific vulnerability in the striatum: implication for ischemia and Huntington's disease

21 January 2018

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21 January 2018

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21 January 2018

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Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis

21 January 2018

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Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

21 January 2018

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The metabotropic glutamate receptors: structure and functions

21 January 2018

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Pharmacology and functions of metabotropic glutamate receptors

21 January 2018

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21 January 2018

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Metabotropic glutamate receptors in the tripartite synapse as a target for new psychotropic drugs

21 January 2018

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Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain

21 January 2018

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The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction.

21 January 2018

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Activation of presynaptic group I metabotropic glutamate receptors enhances glutamate release in the rat spinal cord substantia gelatinosa.

21 January 2018

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Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Functional coupling between ryanodine receptors and L-type calcium channels in neurons.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Positive and negative coupling of the metabotropic glutamate receptors to a G protein-activated K+ channel, GIRK, in Xenopus oocytes

21 January 2018

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G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Proteomic analysis of NMDA receptor-adhesion protein signaling complexes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Metabotropic glutamate receptor-mediated cell signaling pathways are altered in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

The hunt for huntingtin function: interaction partners tell many different stories

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Loss of normal huntingtin function: new developments in Huntington's disease research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Transcriptional signatures in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Reduction in enkephalin and substance P messenger RNA in the striatum of early grade Huntington's disease: a detailed cellular in situ hybridization study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Dopamine D1 and D2 receptor gene expression in the striatum in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Early and transient alteration of adenosine A2A receptor signaling in a mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Unraveling a role for dopamine in Huntington's disease: the dual role of reactive oxygen species and D2 receptor stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Dopamine D2 receptor stimulation potentiates PolyQ-Huntingtin-induced mouse striatal neuron dysfunctions via Rho/ROCK-II activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Dopaminergic signaling and striatal neurodegeneration in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration: the role of p25/cyclin-dependent kinase 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Molecular characterization of a peripheral receptor for cannabinoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Isolation and structure of a brain constituent that binds to the cannabinoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

A second endogenous cannabinoid that modulates long-term potentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

The effects of cannabinoids on the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

21 January 2018

Cannabis and the brain

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Differential role of the hippocampal endocannabinoid system in the memory consolidation and retrieval mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Biochemistry and pharmacology of endovanilloids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Endocannabinoids and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

The endocannabinoid system as a target for the treatment of motor dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Cannabinoid-dopamine interaction in the pathophysiology and treatment of CNS disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Loss of cannabinoid receptors in the substantia nigra in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Effects of systemic 3-nitropropionic acid-induced lesions of the dorsal striatum on cannabinoid and mu-opioid receptor binding in the basal ganglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Molecular and behavioral analysis of the R6/1 Huntington's disease transgenic mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Neurotrophins: roles in neuronal development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Neuroprotection in Parkinson's disease: an elusive goal

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Molecular targets and therapeutic strategies in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Glutamate excitotoxicity and therapeutic targets for amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Excitotoxic mechanisms in stroke: an update of concepts and treatment strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Alzheimer' s disease, oxidative stress and gammahydroxybutyrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Molecular mechanisms in the pathogenesis and treatment of acute ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Mitochondria, oxidative metabolism and cell death in stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

NMDA receptor losses in putamen from patients with Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

A primate model of Huntington's disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Mutant huntingtin enhances excitotoxic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Structural properties of the NMDA receptor and the design of neuroprotective therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Neuroprotective and behavioral effects of the selective metabotropic glutamate mGlu(1) receptor antagonist BAY 36-7620.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Metabotropic glutamate 1 (mGlu1) receptor antagonists enhance GABAergic neurotransmission: a mechanism for the attenuation of post-ischemic injury and epileptiform activity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Activation of mGlu1 but not mGlu5 metabotropic glutamate receptors contributes to postischemic neuronal injury in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

mGluR1 antagonist decreases tyrosine phosphorylation of NMDA receptor and attenuates infarct size after transient focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Evidence against a permissive role of the metabotropic glutamate receptor 1 in acute excitotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Differential role of mGlu1 and mGlu5 receptors in rat hippocampal slice models of ischemic tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Intraneuronal -Amyloid Expression Downregulates the Akt Survival Pathway and Blunts the Stress Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-010-8153-1

Activation of a Large-conductance Ca2+-Dependent K+ Channel by Stimulation of Glutamate Phosphoinositide-coupled Receptors in Cultured Cerebellar Granule Cells

21 January 2018

1 reference

12 December 2020

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

1 reference

12 December 2020

The glutamate receptor ion channels

1 reference

12 December 2020

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system

1 reference

12 December 2020

NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum.

1 reference

12 December 2020

Loss of cannabinoid CB(1) receptors in the basal ganglia in the late akinetic phase of rats with experimental Huntington's disease

1 reference

12 December 2020

Metabotropic glutamate receptors coupled to IP3 production mediate inhibition of IAHP in rat dentate granule neurons.

1 reference

12 December 2020

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10.1007/S12035-010-8153-1

Identifiers

DOI

1 reference

23 August 2017

1 reference

PubMed ID

21153060