The hunt for huntingtin function: interaction partners tell many different stories (Q28203006)

Trends in Biochemical Sciences

Europe PubMed Central

title

The hunt for huntingtin function: interaction partners tell many different stories (English)

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author name string

Phoebe Harjes

series ordinal

1

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Erich E Wanker

series ordinal

2

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language of work or name

English

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publication date

August 2003

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published in

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volume

28

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page(s)

425-33

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issue

8

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cites work

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Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

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Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies

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Inactivation of the mouse Huntington's disease gene homolog Hdh

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Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

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Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

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Expression of the Huntingtin-associated protein 1 gene in the developing and adult mouse.

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Loss of normal huntingtin function: new developments in Huntington's disease research

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The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

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7 January 2021

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

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7 January 2021

Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin

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7 January 2021

Accessory factors in clathrin-dependent synaptic vesicle endocytosis

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7 January 2021

Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95.

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

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7 January 2021

Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations

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7 January 2021

Transcriptional activation modulated by homopolymeric glutamine and proline stretches

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7 January 2021

SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates

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7 January 2021

PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains

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7 January 2021

HEAT repeats in the Huntington's disease protein

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Comparison of ARM and HEAT protein repeats

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HEAT repeats associated with condensins, cohesins, and other complexes involved in chromosome-related functions

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The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

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7 January 2021

Protein repeats: structures, functions, and evolution

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Structure of importin-beta bound to the IBB domain of importin-alpha

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7 January 2021

HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system

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7 January 2021

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

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7 January 2021

A huntingtin-associated protein enriched in brain with implications for pathology

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7 January 2021

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis

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7 January 2021

Snap-shots of clathrin-mediated endocytosis

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7 January 2021

Endocytosis and the cytoskeleton

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7 January 2021

Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1).

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7 January 2021

HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin

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7 January 2021

Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae

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7 January 2021

Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis.

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7 January 2021

Curvature of clathrin-coated pits driven by epsin

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7 January 2021

The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis

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7 January 2021

HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain

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7 January 2021

Functional genomic analysis reveals the utility of the I/LWEQ module as a predictor of protein:actin interaction

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7 January 2021

Huntingtin interacts with a family of WW domain proteins

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7 January 2021

An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles

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7 January 2021

HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2

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7 January 2021

Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins

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7 January 2021

The actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitro

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7 January 2021

A presynaptic inositol-5-phosphatase

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7 January 2021

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases

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7 January 2021

The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain

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7 January 2021

Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid.

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7 January 2021

The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport

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7 January 2021

Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration.

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7 January 2021

Motor-cargo interactions: the key to transport specificity.

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7 January 2021

Fast transport and retrograde movement of huntingtin and HAP 1 in axons.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

beta III spectrin binds to the Arp1 subunit of dynactin

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

Postsynaptic organization and regulation of excitatory synapses

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7 January 2021

Postsynaptic signaling and plasticity mechanisms

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7 January 2021

SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family

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7 January 2021

Signal transduction. How receptors turn Ras on.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

SH3 domain-dependent association of huntingtin with epidermal growth factor receptor signaling complexes

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7 January 2021

The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis

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7 January 2021

Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

Arfaptin 2 regulates the aggregation of mutant huntingtin protein

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

Expression of huntingtin-associated protein-1 in neuronal cells implicates a role in neuritic growth

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7 January 2021

Dendritic spines: structure, dynamics and regulation

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

CREB-binding protein sequestration by expanded polyglutamine

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7 January 2021

The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

Mechanism of transcriptional activation by Sp1: evidence for coactivators

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

Interaction of Huntington disease protein with transcriptional activator Sp1

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7 January 2021

Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

Wild-type huntingtin protects from apoptosis upstream of caspase-3.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

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7 January 2021

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

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7 January 2021

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

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7 January 2021

The cell as a collection of protein machines: preparing the next generation of molecular biologists

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7 January 2021

The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900168-3

7 January 2021

The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor

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7 January 2021

10.1016/S0968-0004(03)00168-3

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

3252156

3252156

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference