The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt. (Q44025697)

29 November 2017

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt. (English)

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29 November 2017

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Fabrice P Cordelières

object named as

Fabrice P Cordelières

3

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author name string

Sandrine Humbert

1

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29 November 2017

Elzbieta A Bryson

2

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29 November 2017

Nathan C Connors

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29 November 2017

Sandeep R Datta

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29 November 2017

Steven Finkbeiner

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29 November 2017

Michael E Greenberg

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29 November 2017

Frédéric Saudou

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29 November 2017

language of work or name

English

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publication date

1 June 2002

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29 November 2017

7

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inferred from page(s)

published in

Developmental Cell

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29 November 2017

2

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29 November 2017

6

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29 November 2017

831-837

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Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

29 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington's disease.

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Replicating Huntington's disease phenotype in experimental animals

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Transcriptional dysregulation in Huntington's disease

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Rediscovering good old friend IGF-I in the new millenium: possible usefulness in Alzheimer's disease and stroke.

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Androgen receptor mutation in Kennedy's disease

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Phosphorylation-dependent Akt cleavage in neural cell in vitro reconstitution of apoptosis

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain

1 reference

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7 January 2021

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

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7 January 2021

A huntingtin-associated protein enriched in brain with implications for pathology

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Nuclear targeting of mutant Huntingtin increases toxicity

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis

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https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Motoneuronal cell death is not correlated with aggregate formation of androgen receptors containing an elongated polyglutamine tract

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900188-0

7 January 2021

10.1016/S1534-5807(02)00188-0

Identifiers

DOI

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release_ry4jxqhb4nephcihzbjqykc27y

29 November 2017

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Fatcat

https://api.fatcat.wiki/v0/release/ry4jxqhb4nephcihzbjqykc27y

24 November 2022

mapped directly with Wikidata item

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