Scatter-factor and semaphorin receptors: cell signalling for invasive growth (Q34632043)

3 August 2017

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title

Scatter-factor and semaphorin receptors: cell signalling for invasive growth (English)

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semaphorin receptor binding

3 August 2017

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Gene Ontology release 2020-05-02

Livio Trusolino

1

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3 August 2017

Paolo M Comoglio

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 April 2002

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3 August 2017

Nature Reviews Cancer

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3 August 2017

2

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3 August 2017

289-300

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3 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrc779

3 August 2017

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Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

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Molecular cloning and expression of human hepatocyte growth factor

31 March 2020

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Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity

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Tyrosine kinase receptor indistinguishable from the c-met protein

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Identification of the ron gene product as the receptor for the human macrophage stimulating protein

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The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules

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Plexin A is a neuronal semaphorin receptor that controls axon guidance

31 March 2020

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Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates

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Signalling by semaphorin receptors: cell guidance and beyond.

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Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors

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Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis

31 March 2020

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Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells

31 March 2020

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Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth

31 March 2020

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Scatter factor/hepatocyte growth factor is essential for liver development

31 March 2020

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Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

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Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

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Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons

31 March 2020

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Hepatocyte growth factor promotes motor neuron survival and synergizes with ciliary neurotrophic factor

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Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons.

31 March 2020

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Multiple roles for hepatocyte growth factor in sympathetic neuron development.

31 March 2020

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Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones

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Ectopic semaphorin-1a functions as an attractive guidance cue for developing peripheral neurons

31 March 2020

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Chemoattraction and chemorepulsion of olfactory bulb axons by different secreted semaphorins.

31 March 2020

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Semaphorin 3A is a chemoattractant for cortical apical dendrites.

31 March 2020

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Molecular cloning of a new transforming gene from a chemically transformed human cell line.

31 March 2020

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Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation

31 March 2020

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Role of morphogenetic factors in metastasis of mammary carcinoma cells.

31 March 2020

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Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors

31 March 2020

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The mutationally activated Met receptor mediates motility and metastasis

31 March 2020

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Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice

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Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor

31 March 2020

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Overexpression of the Met/HGF receptor in ovarian cancer.

31 March 2020

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Overexpression of the met/HGF receptor in renal cell carcinomas

31 March 2020

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Expression of Met protein in thyroid tumours

31 March 2020

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Expression of hepatocyte growth factor and its receptor, the c-met proto-oncogene, in hepatocellular carcinoma

31 March 2020

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Expression of scatter factor and c-met receptor in benign and malignant breast tissue

31 March 2020

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Expression of Met protein and urokinase-type plasminogen activator receptor (uPA-R) in papillary carcinoma of the thyroid

31 March 2020

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Met expression is associated with poor outcome in patients with axillary lymph node negative breast carcinoma

31 March 2020

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Overexpression of c-Met protein in human thyroid tumors correlated with lymph node metastasis and clinicopathologic stage

31 March 2020

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u-PA and c-MET mRNA expression is co-ordinately enhanced while hepatocyte growth factor mRNA is down-regulated in human hepatocellular carcinoma

31 March 2020

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Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer

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Over-expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma

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Expression of the hepatocyte growth factor/c-Met pathway is increased at the cancer front in breast carcinoma

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Changes in gene expression during progression of ovarian carcinoma.

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Overexpression of the c-met protooncogene in human gastric carcinoma--correlation to clinical features.

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Examination of oncogene amplification by genomic DNA microarray in hepatocellular carcinomas: comparison with comparative genomic hybridization analysis.

31 March 2020

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MET receptor is overexpressed but not mutated in oral squamous cell carcinomas.

31 March 2020

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Gene expression in papillary thyroid carcinoma reveals highly consistent profiles

31 March 2020

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Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

31 March 2020

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Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours

31 March 2020

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Novel mutations of the MET proto-oncogene in papillary renal carcinomas.

31 March 2020

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Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinase in a HPRCC family

31 March 2020

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A novel germ line juxtamembrane Met mutation in human gastric cancer

31 March 2020

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Activating mutations for the met tyrosine kinase receptor in human cancer

31 March 2020

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Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists

31 March 2020

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Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas

31 March 2020

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Hepatocyte growth factor/scatter factor is present in most pleural effusion fluids from cancer patients

31 March 2020

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Molecular architecture of adherens junctions

31 March 2020

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Effect of hepatocyte growth factor on the expression of E- and P-cadherin in gastric carcinoma cell lines

31 March 2020

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Effects of hepatocyte growth factor on E-cadherin-mediated cell-cell adhesion in DU145 prostate cancer cells

31 March 2020

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Hepatocyte growth factor alters the polarity of Madin-Darby canine kidney cell monolayers

31 March 2020

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Dynamics of E-cadherin and gamma-catenin complexes during dedifferentiation of polarized MDCK cells

31 March 2020

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31 March 2020

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Ligand binding to integrins

31 March 2020

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Integrin modulation by lateral association

31 March 2020

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Hepatocyte growth factor enables enhanced integrin-cytoskeleton linkage by affecting integrin expression in subconfluent epithelial cells

31 March 2020

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Sustained activation of extracellular signal-regulated kinase stimulated by hepatocyte growth factor leads to integrin alpha 2 expression that is involved in cell scattering

31 March 2020

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Growth factor-dependent activation of alphavbeta3 integrin in normal epithelial cells: implications for tumor invasion

31 March 2020

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Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.

31 March 2020

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Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5

31 March 2020

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Involvement of matrix metalloproteinase type-3 in hepatocyte growth factor-induced invasion of human hepatocellular carcinoma cells

31 March 2020

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Mechanisms of angiogenesis and arteriogenesis

31 March 2020

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Identification of semaphorin E gene expression in metastatic human lung adenocarcinoma cells by mRNA differential display

31 March 2020

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Identification of semaphorin E as a non-MDR drug resistance gene of human cancers

31 March 2020

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Cell signaling by receptor tyrosine kinases

31 March 2020

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A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

31 March 2020

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Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

31 March 2020

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Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis

31 March 2020

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The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase

31 March 2020

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Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

31 March 2020

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Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

31 March 2020

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Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth

31 March 2020

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Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development

31 March 2020

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Motogenic and morphogenic activity of epithelial receptor tyrosine kinases

31 March 2020

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A point mutation in the MET oncogene abrogates metastasis without affecting transformation.

31 March 2020

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Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis.

31 March 2020

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A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth

31 March 2020

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Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

31 March 2020

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The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

31 March 2020

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Sequential steps in clathrin-mediated synaptic vesicle endocytosis.

31 March 2020

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The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidance

31 March 2020

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Rho GTPases in neuronal morphogenesis

31 March 2020

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Rho GTPases in growth cone guidance

31 March 2020

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The semaphorin 3A receptor may directly regulate the activity of small GTPases.

31 March 2020

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The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner

31 March 2020

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Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho.

31 March 2020

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Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling

31 March 2020

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Receptor tyrosine kinases: specific outcomes from general signals

31 March 2020

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Signaling networks--do all roads lead to the same genes?

31 March 2020

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Coupling Met to specific pathways results in distinct developmental outcomes

31 March 2020

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Differential MAPK pathways utilized for HGF- and EGF-dependent renal epithelial morphogenesis

31 March 2020

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A differentiation switch for genetically modified hepatocytes

31 March 2020

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Identification of a Competitive HGF Antagonist Encoded by an Alternative Transcript

31 March 2020

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A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis

31 March 2020

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Hepatocyte growth factor (HGF)/NK1 is a naturally occurring HGF/scatter factor variant with partial agonist/antagonist activity

31 March 2020

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Functional characterization of domains contained in hepatocyte growth factor-like protein

31 March 2020

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Cooperative interaction between alpha- and beta-chains of hepatocyte growth factor on c-Met receptor confers ligand-induced receptor tyrosine phosphorylation and multiple biological responses.

31 March 2020

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Interaction of macrophage-stimulating protein with its receptor. Residues critical for beta chain binding and evidence for independent alpha chain binding

31 March 2020

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Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice

31 March 2020

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Clinical significance of human hepatocyte growth factor in blood from patients with fulminant hepatic failure

31 March 2020

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Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin. A morphologic study

31 March 2020

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Hepatocyte growth factor gene therapy of liver cirrhosis in rats

31 March 2020

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Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models

31 March 2020

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In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis.

31 March 2020

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Unified nomenclature for the semaphorins/collapsins. Semaphorin Nomenclature Committee

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC779

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Dimensions Publication ID

3 August 2017

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