Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis (Q28139783)

2

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T A Williams

3

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S Rocchi

4

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E Van Obberghen

5

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P M Comoglio

Mitogenic response to epidermal growth factor: Relationship to number, affinity, and down-regulation of EGF receptors in three murine embyro cell lines

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language of work or name

English

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publication date

16 March 2000

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published in

Oncogene

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volume

19

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issue

12

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page(s)

1509-18

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cites work

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Calcium - a life and death signal

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Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

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p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells

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Calcium oscillations increase the efficiency and specificity of gene expression

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

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Branching tubulogenesis but not scatter of madin-darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase

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PI3K: downstream AKTion blocks apoptosis

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Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

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The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

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Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway

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PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.

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A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

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Kinetic analysis of transcytosis of epidermal growth factor in Madin-Darby canine kidney epithelial cells

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The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

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Phospholipase C-gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance.

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Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

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Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.

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Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

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A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

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Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility

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Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules

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Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase.

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Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

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Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

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Selective phospholipase C activation

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Requirement for phospholipase C-gamma1 enzymatic activity in growth factor-induced mitogenesis

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Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

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Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok

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The IRS-signalling system during insulin and cytokine action

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Identification by mutation of the tyrosine residues in the insulin receptor substrate-1 affecting association with the tyrosine phosphatase 2C and phosphatidylinositol 3-kinase

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Hepatocyte growth factor induces activation of Nck and phospholipase C-gamma in lung carcinoma cells

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Cell density-dependent regulation of hepatocyte growth factor receptor on adult rat hepatocytes in primary culture

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Internalization and degradation of hepatocyte growth factor in hepatocytes with down-regulation of the receptor/c-Met

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Frequency modulation of Ca2+ sparks is involved in regulation of arterial diameter by cyclic nucleotides.

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Differential requirement of Grb2 and PI3-kinase in HGF/SF-induced cell motility and tubulogenesis

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Effect of scatter factor on motility of epithelial cells and fibroblasts

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