Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease (Q36089364)

12 August 2017

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title

Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease (English)

1 reference

12 August 2017

0 references

1 reference

Kobayashi DT

1

1 reference

PubMed ID

15810905

12 August 2017

Chen KS

series ordinal

2

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PubMed ID

15810905

12 August 2017

language of work or name

English

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publication date

1 April 2005

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Genes, Brain and Behavior

12 August 2017

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12 August 2017

4

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12 August 2017

173-196

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12 August 2017

3

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Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation.

12 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Intra- and intertask relationships in a behavioral test battery given to Tg2576 transgenic mice and controls.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Short-term beta-amyloid vaccinations do not improve cognitive performance in cognitively impaired APP + PS1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Selective nicotinic receptor consequences in APP(SWE) transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Comparative localization of ADAMs 10 and 15 in human cerebral cortex normal aging, Alzheimer disease and Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Beta-secretase activity increases with aging in human, monkey, and mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Behavioral impairment of APP(V717F) mice in fear conditioning: is it only cognition?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Age-independent and age-related deficits in visuospatial learning, sleep-wake states, thermoregulation and motor activity in PDAPP mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

APP processing and synaptic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Metalloprotease-disintegrin (ADAM) genes are widely and differentially expressed in the adult CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Progressive age-related impairment of cognitive behavior in APP23 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging: correlations with cognitive impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Postsynaptic signaling of new players at the neuromuscular junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Transgenic mice expressing the PS1-A246E mutation: effects on spatial learning, exploration, anxiety, and motor coordination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Transgenic mice expressing the betaAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

The metabolic pathway generating p3, an A beta-peptide fragment, is probably non-amyloidogenic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Hypothermia impairs performance in the Morris water maze.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Measuring memory in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

The molecular pathology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Brain Abeta amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Age-dependent cognitive decline in the APP23 model precedes amyloid deposition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Impaired eyeblink conditioning and decreased hippocampal volume in PDAPP V717F mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00124.X

10.1111/J.1601-183X.2005.00124.X

21 January 2018

Identifiers

DOI

1 reference

12 August 2017

1 reference

PubMed ID

15810905