Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients (Q24633400)

1

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Kristina Lindholm

2

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Li-Bang Yang

3

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Xu Yue

4

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Martin Citron

5

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Riqiang Yan

6

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Lucia Sue

8

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Marwan Sabbagh

9

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Huaibin Cai

10

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Philip Wong

11

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Donald Price

12

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Yong Shen

Proceedings of the National Academy of Sciences of the United States of America

13

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language of work or name

English

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publication date

9 March 2004

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published in

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volume

101

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page(s)

3632-7

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issue

10

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cites work

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

7 April 2017

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

7 April 2017

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

7 April 2017

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Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

7 April 2017

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Alzheimer's disease: genes, proteins, and therapy

7 April 2017

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beta-site APP cleaving enzyme mRNA expression in APP transgenic mice: anatomical overlap with transgene expression and static levels with aging

7 April 2017

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Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

7 April 2017

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

7 April 2017

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

7 April 2017

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

7 April 2017

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Isolation of living neurons from human elderly brains using the immunomagnetic sorting DNA-linker system

7 April 2017

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The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease.

27 September 2017

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

27 September 2017

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Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain

27 September 2017

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Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

27 September 2017

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Alzheimer's disease: perspectives for the new millennium

27 September 2017

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Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

27 September 2017

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Mutations in the open reading frame of the beta-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease.

27 September 2017

1 reference

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The role of A beta 42 in Alzheimer's disease

30 May 2018

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Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease.

30 May 2018

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The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects.

30 May 2018

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Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373514

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373514

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373514

Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373514

Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373514

Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373514

Characterization of glial cultures from rapid autopsies of Alzheimer's and control patients.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373514

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373514

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373514

Estrogen enhances uptake of amyloid beta-protein by microglia derived from the human cortex

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14978286

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0205689101

1 reference

1537799

ADS bibcode

2004PNAS..101.3632L

0 references

1537799

1 reference

1 reference

1 reference