Beta-secretase activity increases with aging in human, monkey, and mouse brain. (Q35083409)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14742275%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

title

Beta-secretase activity increases with aging in human, monkey, and mouse brain (English)

1 reference

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17 November 2019

2

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17 November 2019

Mark Moss

3

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17 November 2019

5

Bradley T Hyman

1 reference

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17 November 2019

author name string

Hiroaki Fukumoto

1

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17 November 2019

Susan Raju

4

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17 November 2019

Michael C Irizarry

6

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17 November 2019

language of work or name

English

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publication date

1 February 2004

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The American Journal of Pathology

17 November 2019

published in

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17 November 2019

volume

164

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17 November 2019

issue

2

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17 November 2019

page(s)

719-725

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Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))

17 November 2019

cites work

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Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation

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Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent

8 July 2018

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8 July 2018

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Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

8 July 2018

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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

8 July 2018

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Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology

8 July 2018

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Phosphorylation regulates intracellular trafficking of beta-secretase

8 July 2018

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The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

8 July 2018

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

8 July 2018

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Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

8 July 2018

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beta-site APP cleaving enzyme mRNA expression in APP transgenic mice: anatomical overlap with transgene expression and static levels with aging

8 July 2018

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Maturation and pro-peptide cleavage of beta-secretase

8 July 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

8 July 2018

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Presenilin-1, amyloid precursor protein and amyloid precursor-like protein 2 mRNA levels in human superior frontal cortex during aging.

8 July 2018

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Lack of correlation between plaque burden and cognition in the aged monkey.

8 July 2018

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Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

8 July 2018

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Developmental regulation of presenilin mRNA expression parallels notch expression.

8 July 2018

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

8 July 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

8 July 2018

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Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques

8 July 2018

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

8 July 2018

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Neuritic (senile) plaques and filamentous changes in aged rhesus monkeys

8 July 2018

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Senile plaques in cortex of aged normal monkeys.

8 July 2018

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Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease.

8 July 2018

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The prevalence of dementia: a quantitative integration of the literature

8 July 2018

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8 July 2018

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The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease

8 July 2018

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Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

8 July 2018

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Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

27 September 2018

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Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging.

27 September 2018

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Oxidative stress increases expression and activity of BACE in NT2 neurons

27 September 2018

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Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

27 September 2018

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Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

27 September 2018

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BACE1 interacts with nicastrin

27 September 2018

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Localization of beta-secretase memapsin 2 in the brain of Alzheimer's patients and normal aged controls

27 September 2018

1 reference

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Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

27 September 2018

1 reference

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27 September 2018

1 reference

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Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain

27 September 2018

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Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production

27 September 2018

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Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease.

27 September 2018

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APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

27 September 2018

1 reference

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Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

27 September 2018

1 reference

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The beta APP717 Alzheimer mutation increases the percentage of plasma amyloid-beta protein ending at A beta42(43).

27 September 2018

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

27 September 2018

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Crossref

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963159-8

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963159-8

Proteolytic activation of recombinant pro-memapsin 2 (pro-beta-secretase) studied with new fluorogenic substrates

7 January 2021

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10.1016/S0002-9440(10)63159-8

7 January 2021

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14742275%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14742275%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

1 reference