Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia (Q35779725)

10 August 2017

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title

Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia (English)

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10 August 2017

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2

Mel Greaves

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10 August 2017

3

Tariq Enver

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10 August 2017

Arthur Zelent

1

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PubMed ID

15156184

10 August 2017

language of work or name

English

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publication date

1 May 2004

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10 August 2017

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10 August 2017

23

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10 August 2017

24

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10 August 2017

4275-4283

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207672

10 August 2017

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cites work

The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

The leukemia-associated gene TEL encodes a transcription repressor which associates with SMRT and mSin3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Functional characterization of ETV6 and ETV6/CBFA2 in the regulation of the MCSFR proximal promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Histone and chromatin cross-talk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

21 January 2018

Role of FLT3 in leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Origins of chromosome translocations in childhood leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Presence of clone-specific markers at birth in children with acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

TEL is a sequence-specific transcriptional repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Chromosome translocations and covert leukemic clones are generated during normal fetal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

The histone deacetylase 9 gene encodes multiple protein isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Role of promyelocytic leukemia (PML) protein in tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Core-binding factors in haematopoiesis and leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Prognostic significance of TEL/AML1 fusion transcript in childhood B-precursor acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Butyrate suppression of histone deacetylation leads to accumulation of multiacetylated forms of histones H3 and H4 and increased DNase I sensitivity of the associated DNA sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

TLE, the Human Homolog of Groucho, Interacts with AML1 and Acts as a Repressor of AML1-Induced Transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Groucho-dependent and -independent repression activities of Runt domain proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Translocations, cancer and the puzzle of specificity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Acute lymphoblastic leukemia and chromosome 21.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Loops, lineage, and leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Correlation between the ETV6/CBFA2 (TEL/AML1) fusion gene and karyotypic abnormalities in children with B-cell precursor acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Origins of "late" relapse in childhood acute lymphoblastic leukemia with TEL-AML1 fusion genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

B-cell development: a comparison between mouse and man.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Involvement of the TEL gene in hematologic malignancy by diverse molecular genetic mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

The TEL gene and human leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Molecular genetics, natural history and the demise of childhood leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Aetiology of acute leukaemia

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Leukemia in twins: lessons in natural history

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Acute promyelocytic leukemia: where does it stem from?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Histone acetylation in chromatin structure and transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Human acute myeloid leukemia stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Immature CD34+CD19- progenitor/stem cells in TEL/AML1-positive acute lymphoblastic leukemia are genetically and functionally normal

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Eukaryotic transcription: an interlaced network of transcription factors and chromatin-modifying machines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Repression and activation by multiprotein complexes that alter chromatin structure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Late relapses evolve from slow-responding subclones in t(12;21)-positive acute lymphoblastic leukemia: evidence for the persistence of a preleukemic clone.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Oncogenic transcription factors in the human acute leukemias

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Molecular tracking of leukemogenesis in a triplet pregnancy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Protracted postnatal natural histories in childhood leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Focus on embryonal malignancies

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Proteins of the ETS family with transcriptional repressor activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Chromosomal translocations in human cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Tel induces a G1 arrest and suppresses Ras-induced transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

The critical role of chromosome translocations in human leukemias.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

The multistep nature of cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Microclustering of TEL-AML1 translocation breakpoints in childhood acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Prenatal origin of acute lymphoblastic leukaemia in children

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207672

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207672

1 reference

10 August 2017

1 reference

PubMed ID

15156184