Origins of chromosome translocations in childhood leukaemia (Q35210004)

7 August 2017

1 reference

title

Origins of chromosome translocations in childhood leukaemia (English)

1 reference

7 August 2017

1 reference

Mel F Greaves

1

1 reference

PubMed ID

12951583

7 August 2017

Joe Wiemels

series ordinal

2

1 reference

PubMed ID

12951583

7 August 2017

language of work or name

English

0 references

publication date

1 September 2003

1 reference

7 August 2017

Nature Reviews Cancer

1 reference

7 August 2017

3

1 reference

7 August 2017

639-649

1 reference

7 August 2017

9

1 reference

https://scigraph.springernature.com/pub.10.1038/nrc1164

7 August 2017

0 references

cites work

Oncogenic transcription factors in the human acute leukemias

1 reference

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

21 January 2018

1 reference

Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles

21 January 2018

1 reference

Chromosomal translocations in human cancer.

21 January 2018

1 reference

The critical role of chromosome translocations in human leukemias.

21 January 2018

1 reference

How do tumors make ends meet?

21 January 2018

1 reference

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

21 January 2018

1 reference

Disruption of differentiation in human cancer: AML shows the way.

21 January 2018

1 reference

Core-binding factors in haematopoiesis and leukaemia

21 January 2018

1 reference

Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation

21 January 2018

1 reference

Genomic anatomy of the specific reciprocal translocation t(15;17) in acute promyelocytic leukemia

21 January 2018

1 reference

DNA double-strand breaks: signaling, repair and the cancer connection

21 January 2018

1 reference

Double strand break repair

21 January 2018

1 reference

Molecular mechanisms of DNA double strand break repair

21 January 2018

1 reference

Mechanisms of chromosomal translocations in B cell lymphomas

21 January 2018

1 reference

Genomic acute myeloid leukemia-associated inv(16)(p13q22) breakpoints are tightly clustered.

21 January 2018

1 reference

Cryptic signals and the fidelity of V(D)J joining

21 January 2018

1 reference

Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints

21 January 2018

1 reference

V(D)J-mediated translocations in lymphoid neoplasms: a functional assessment of genomic instability by cryptic sites.

21 January 2018

1 reference

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

21 January 2018

1 reference

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations.

21 January 2018

1 reference

BCL2 translocation frequency rises with age in humans

21 January 2018

1 reference

Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL.

21 January 2018

1 reference

21 January 2018

1 reference

Small deletion and insertion mutations induced by the topoisomerase II inhibitor teniposide in CHO cells and comparison with sites of drug-stimulated DNA cleavage in vitro

21 January 2018

1 reference

Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation

21 January 2018

1 reference

Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia

21 January 2018

1 reference

Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia

21 January 2018

1 reference

DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis

21 January 2018

1 reference

Nucleolytic cleavage of the mixed lineage leukemia breakpoint cluster region during apoptosis.

21 January 2018

1 reference

Phagocytosis promotes programmed cell death in C. elegans.

21 January 2018

1 reference

Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells

21 January 2018

1 reference

Breakage and fusion of the TEL (ETV6) gene in immature B lymphocytes induced by apoptogenic signals

21 January 2018

1 reference

Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus

21 January 2018

1 reference

DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis

21 January 2018

1 reference

Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia.

21 January 2018

1 reference

Frequent chromosomal translocations induced by DNA double-strand breaks

21 January 2018

1 reference

The role of Alu repeat clusters as mediators of recurrent chromosomal aberrations in tumors

21 January 2018

1 reference

One short well conserved region of Alu-sequences is involved in human gene rearrangements and has homology with prokaryotic chi.

21 January 2018

1 reference

The BCR gene recombines preferentially with Alu elements in complex BCR-ABL translocations of chronic myeloid leukaemia.

21 January 2018

1 reference

A 76-kb duplicon maps close to the BCR gene on chromosome 22 and the ABL gene on chromosome 9: possible involvement in the genesis of the Philadelphia chromosome translocation

21 January 2018

1 reference

The partial tandem duplication of ALL1 (MLL) is consistently generated by Alu-mediated homologous recombination in acute myeloid leukemia

21 January 2018

1 reference

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

21 January 2018

1 reference

Stem cells, cancer, and cancer stem cells

21 January 2018

1 reference

21 January 2018

1 reference

Stem cells: a new lease on life

21 January 2018

1 reference

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

21 January 2018

1 reference

Translocations, cancer and the puzzle of specificity

21 January 2018

1 reference

An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

21 January 2018

1 reference

Stem cell origins of leukaemia and curability

21 January 2018

1 reference

In utero rearrangements in the trithorax-related oncogene in infant leukaemias.

21 January 2018

1 reference

t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes

21 January 2018

1 reference

Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia

21 January 2018

1 reference

Molecular tracking of leukemogenesis in a triplet pregnancy.

21 January 2018

1 reference

Molecular genetics, natural history and the demise of childhood leukaemia

21 January 2018

1 reference

Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots

21 January 2018

1 reference

In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia

21 January 2018

1 reference

Nondisjunction of chromosomes leading to hyperdiploid childhood B-cell precursor acute lymphoblastic leukemia is an early event during leukemogenesis.

21 January 2018

1 reference

21 January 2018

The Hallmarks of Cancer

1 reference

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

21 January 2018

1 reference

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

21 January 2018

1 reference

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

21 January 2018

1 reference

Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fate

21 January 2018

1 reference

The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo

21 January 2018

1 reference

Altered Hox expression and segmental identity in Mll-mutant mice

21 January 2018

1 reference

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

21 January 2018

1 reference

Tel induces a G1 arrest and suppresses Ras-induced transformation

21 January 2018

1 reference

TEL is a sequence-specific transcriptional repressor

21 January 2018

1 reference

Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification

21 January 2018

1 reference

The roles of FLT3 in hematopoiesis and leukemia

21 January 2018

1 reference

Chromosome translocations and covert leukemic clones are generated during normal fetal development

21 January 2018

1 reference

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

21 January 2018

1 reference

Treatment of acute promyelocytic leukaemia.

21 January 2018

1 reference

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

21 January 2018

1 reference

Chromosomal translocation products engender new intracellular therapeutic technologies

21 January 2018

1 reference

Aetiology of acute leukaemia

21 January 2018

1 reference

Daycare attendance and risk of childhood acute lymphoblastic leukaemia

21 January 2018

1 reference

Day-care, early common infections and childhood acute leukaemia: a multicentre French case-control study

21 January 2018

1 reference

Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia

21 January 2018

1 reference

Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study

21 January 2018

1 reference

Presence of clone-specific markers at birth in children with acute lymphoblastic leukaemia

21 January 2018

1 reference

Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16).

21 January 2018

1 reference

Information content of binding sites on nucleotide sequences

21 January 2018

1 reference

Immature CD34+CD19- progenitor/stem cells in TEL/AML1-positive acute lymphoblastic leukemia are genetically and functionally normal

21 January 2018

1 reference

Differentiation-linked leukemogenesis in lymphocytes

21 January 2018

1 reference

Bipotential precursors of B cells and macrophages in murine fetal liver

21 January 2018

1 reference

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

21 January 2018

1 reference

Loops, lineage, and leukemia

31 March 2020

1 reference

Molecular characterization of genomic AML1-ETO fusions in childhood leukemia

31 March 2020

1 reference

Microclustering of TEL-AML1 translocation breakpoints in childhood acute lymphoblastic leukemia

31 March 2020

1 reference

Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia

31 March 2020

1 reference

Secondary leukemias induced by topoisomerase-targeted drugs

31 March 2020

1 reference

International workshop on the relationship of prior therapy to balanced chromosome aberrations in therapy-related myelodysplastic syndromes and acute leukemia: overview report

31 March 2020

1 reference

Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations

31 March 2020

1 reference

Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis

31 March 2020

1 reference

Leukemia in twins: lessons in natural history

31 March 2020

1 reference

Possible explanation of the high concoddance for acute leukaemia in monozygotic twins

31 March 2020

1 reference

Prenatal origin of acute lymphoblastic leukaemia in children

31 March 2020

1 reference

High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia

31 March 2020

1 reference

Origins of "late" relapse in childhood acute lymphoblastic leukemia with TEL-AML1 fusion genes

31 March 2020

1 reference

Spatial proximity of translocation-prone gene loci in human lymphomas

31 March 2020

1 reference

Infant leukemia, topoisomerase II inhibitors, and the MLL gene

31 March 2020

1 reference

Clonal development, stem-cell differentiation, and clinical remissions in acute nonlymphocytic leukemia

31 March 2020

1 reference

Cytogenetic studies of haemopoietic colonies from patients with an initial diagnosis of acute lymphoblastic leukaemia

31 March 2020

1 reference

Prenatal chromosomal diversification of leukemia in monozygotic twins

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1164

1 reference

7 August 2017

1 reference

PubMed ID

12951583