A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia (Q28141676)

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B Linggi

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S Isaac

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E Seto

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S W Hiebert

Journal of Biological Chemistry

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language of work or name

English

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publication date

7 January 2000

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published in

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volume

275

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page(s)

651-6

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issue

1

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cites work

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

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Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells

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The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

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The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

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Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

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The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system

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Isolation of the Drosophila segmentation gene runt and analysis of its expression during embryogenesis.

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AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization

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PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene

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Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

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Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain

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Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1.

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Cooperative binding of Ets-1 and core binding factor to DNA

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Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions

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Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors

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c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer

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CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter

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Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro

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The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation

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Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

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Parathyroid hormone regulates the rat collagenase-3 promoter in osteoblastic cells through the cooperative interaction of the activator protein-1 site and the runt domain binding sequence

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Groucho-dependent and -independent repression activities of Runt domain proteins

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Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

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ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

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WAF1, a potential mediator of p53 tumor suppression

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Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

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Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

21 January 2018

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Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

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The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70.

21 January 2018

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Transcriptional repression by the SMRT-mSin3 corepressor: multiple interactions, multiple mechanisms, and a potential role for TFIIB.

21 January 2018

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Co-activators and co-repressors in the integration of transcriptional responses

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Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors

21 January 2018

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Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1

21 January 2018

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Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit

21 January 2018

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Role of histone deacetylases in acute leukemia.

21 January 2018

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Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

21 January 2018

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Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein

21 January 2018

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Three distinct domains in TEL-AML1 are required for transcriptional repression of the IL-3 promoter

21 January 2018

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release_vkqotkq4ijavbndoqmnewdipju

21 January 2018

Identifiers

DOI

10.1074/JBC.275.1.651

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Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/vkqotkq4ijavbndoqmnewdipju