The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor (Q24650487)

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Y Hou

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K L Durst

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S W Hiebert

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

26 October 1999

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published in

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volume

96

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issue

22

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page(s)

12822-7

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cites work

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

7 April 2017

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The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1

7 April 2017

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Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

7 April 2017

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Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

7 April 2017

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WAF1, a potential mediator of p53 tumor suppression

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Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia

7 April 2017

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

7 April 2017

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Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

7 April 2017

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Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor

7 April 2017

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Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein

7 April 2017

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The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates

28 September 2017

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Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor alpha (CBFalpha) subunit by the leukemia-related PEBP2/CBFbeta-SMMHC fusion protein inhibits PEBP2/CBF-mediated transactivation

28 September 2017

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The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family.

28 September 2017

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Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit

28 September 2017

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Groucho-dependent and -independent repression activities of Runt domain proteins

28 September 2017

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Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors

28 September 2017

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The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

28 September 2017

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The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

28 September 2017

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The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.

28 September 2017

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Identification of the chimeric protein product of the CBFB-MYH11 fusion gene in inv(16) leukemia cells

28 September 2017

1 reference

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Functional domains of the t(8;21) fusion protein, AML-1/ETO.

28 September 2017

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Oncogenic transcription factors in the human acute leukemias

28 September 2017

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Transcriptional regulation during myelopoiesis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23113

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23113

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23113

Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23113

Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.96.22.12822

The critical role of chromosome translocations in human leukemias.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.96.22.12822

Co-activators and co-repressors in the integration of transcriptional responses

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.96.22.12822

Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23113

Role of histone deacetylases in acute leukemia.

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10536006

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Heterogeneity in CBF beta/MYH11 fusion messages encoded by the inv(16)(p13q22) and the t(16;16)(p13;q22) in acute myelogenous leukemia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10536006

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10536006