Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis (Q24567977)

2

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M Binder

3

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M Marin-Padilla

4

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A H Sharpe

5

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N A Speck

Proceedings of the National Academy of Sciences of the United States of America

6

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publication date

16 April 1996

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language of work or name

English

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published in

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volume

93

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issue

8

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page(s)

3444-9

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cites work

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The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1

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The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript

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Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development

24 March 2017

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Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

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Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

24 March 2017

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

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Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

24 March 2017

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24 March 2017

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Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells

24 March 2017

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Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

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Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo

24 March 2017

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

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Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein

24 March 2017

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Sex determination and dosage compensation in Drosophila melanogaster: production of male clones in XX females

24 March 2017

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Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1.

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Hematopoietic commitment during embryonic stem cell differentiation in culture

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PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene

27 September 2017

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Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations

27 September 2017

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RETRACTED: The leukemic core binding factor beta-smooth muscle myosin heavy chain (CBF beta-SMMHC) chimeric protein requires both CBF beta and myosin heavy chain domains for transformation of NIH 3T3 cells

27 September 2017

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The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.

27 September 2017

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Acute Myeloid Leukemia with Inv(16) Produces a Chimeric Transcription Factor with a Myosin Heavy Chain Tail

27 September 2017

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High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.

27 September 2017

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Properties of the earliest clonogenic hemopoietic precursors to appear in the developing murine yolk sac.

27 September 2017

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t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

27 September 2017

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A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

27 September 2017

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Production of homozygous mutant ES cells with a single targeting construct

27 September 2017

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Hereditary anemias of the mouse: a review for geneticists

27 September 2017

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Functional domains of the t(8;21) fusion protein, AML-1/ETO.

27 September 2017

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Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha

27 September 2017

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Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development

30 May 2018

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Expression of runt in the mouse embryo

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39628

Early vascularization of the embryonic cerebral cortex: Golgi and electron microscopic studies

30 May 2018

1 reference

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Expression and function of the Drosophila gene runt in early stages of neural development

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39628

The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethal

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39628

The Runt domain identifies a new family of heteromeric transcriptional regulators

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39628

TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis

28 November 2018

1 reference

12 December 2020

Ontogeny of the Haemopoietic System: Yolk Sac Origin of In Vivo and In Vitro Colony Forming Cells in the Developing Mouse Embryo

1 reference

12 December 2020

On the fine structure of the arachnoidea and dura mater of mammals

1 reference

12 December 2020

Compartments and perivascular arrangement of the meninges covering the cerebral cortex of the rat

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12 December 2020

Identifiers

DOI

10.1073/PNAS.93.8.3444

1 reference

ADS bibcode

1996PNAS...93.3444W

0 references

1 reference

1 reference

PubMed publication ID

8622955

1 reference