Cancer and aging: a model for the cancer promoting effects of the aging stroma (Q34801698)

4 August 2017

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title

Cancer and aging: a model for the cancer promoting effects of the aging stroma (English)

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4 August 2017

Ana Krtolica

1

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PubMed ID

12200035

4 August 2017

Judith Campisi

series ordinal

2

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4 August 2017

1 November 2002

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International Journal of Biochemistry & Cell Biology

4 August 2017

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4 August 2017

34

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4 August 2017

1401-1414

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4 August 2017

11

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Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal.

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Tumor suppressor genes

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Tumor suppressor genes

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Cancer and age in the USA.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

1 reference

7 January 2021

Cancer in the elderly. Epidemiologic and clinical implications.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Gerontology as oncology. Research on aging as the key to the understanding of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Somatic mutagenesis and antimutagenesis in aging research

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Recent advances in research on multistage tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Mouse models for multistep tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Cell and environment interactions in tumor microregions: the multicell spheroid model

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Altered angiogenesis underlying age-dependent changes in tumor growth

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Angiogenesis in breast cancer is related to age but not to other prognostic parameters

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Cancer: the rise of the genetic paradigm

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Loss of heterozygosity in normal tissue adjacent to breast carcinomas.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Frequent clones of p53-mutated keratinocytes in normal human skin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Rapid accumulation of genome rearrangements in liver but not in brain of old mice

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Chasing the cancer demon

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Genome changes and gene expression in human solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Cancer cells exhibit a mutator phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Genetic instability and darwinian selection in tumours

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Extensive ductal carcinoma In situ with small foci of invasive ductal carcinoma: evidence of genetic resemblance by CGH.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Comparative genomic hybridization detects genetic alterations during early stages of cervical cancer progression.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

The influence of the microenvironment on the malignant phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Overcoming cellular senescence in human cancer pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Plasticity of the neoplastic phenotype in vivo is regulated by epigenetic factors

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

The microenvironment of the tumour-host interface

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Stromal involvement in malignant growth

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Stromal regulation of epithelial function

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Know thy neighbor: stromal cells can contribute oncogenic signals

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Tumour-stromal interactions. Integrins and cell adhesions as modulators of mammary cell survival and transformation.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Tumorigenic conversion of immortal human keratinocytes through stromal cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Cellular senescence revisited: a review

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Replicative senescence of human fibroblast-like cells in culture

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Replicative senescence and cell immortality: the role of telomeres and telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Telomeres and telomerase: implications for cancer and aging

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Cellular senescence, cancer and aging: the telomere connection

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Structure and function of telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Telomere end-replication problem and cell aging

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Telomeres shorten during ageing of human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Cellular senescence as a tumor-protection mechanism: the essential role of counting

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Telomere states and cell fates.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

CELL BIOLOGY: Enhanced: Telomere Capping--One Strand Fits All

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Telomerase and chromosome end maintenance.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Mammalian telomeres and telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

The role of telomerase expression and telomere length maintenance in human and mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

The telomerase reverse transcriptase: components and regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

The role of senescence and immortalization in carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Specific association of human telomerase activity with immortal cells and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Oxidative DNA damage and senescence of human diploid fibroblast cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Emerging roles for chromatin remodeling in cancer biology

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Transcriptional control at regulatory checkpoints by histone deacetylases: molecular connections between cancer and chromatin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Senescence of human fibroblasts induced by oncogenic Raf.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Tumor suppressors and oncogenes in cellular senescence.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Genes involved in senescence and immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Regulation of cellular senescence by p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Cellular senescence as a tumor-suppressor mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Senescence as a mode of tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Mouse models in tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Cancer from the outside, aging from the inside: mouse models to study the consequences of defective nucleotide excision repair

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Mice without telomerase: what can they teach us about human cancer?

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Human Cells and Aging

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Replicative senescence: implications for in vivo aging and tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

From cells to organisms: can we learn about aging from cells in culture?

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Aging and cancer: the double-edged sword of replicative senescence

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Loss of expression of a differentiated function gene, steroid 17 alpha-hydroxylase, as adrenocortical cells senescence in culture

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Cataloging altered gene expression in young and senescent cells using enhanced differential display

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Extension of the life-span of human endothelial cells by an interleukin-1 alpha antisense oligomer

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Replicative senescence: an old lives' tale?

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Telomere length, aging, and somatic cell turnover

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Oxidants, oxidative stress and the biology of ageing

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Replicative senescence: considerations relating to the stability of heterochromatin domains

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

The heterochromatin loss model of aging

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

The two-process model of cellular aging

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

1 reference

7 January 2021

Senescence and the healing rates of venous ulcers

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Cellular proliferation potential during aging and caloric restriction in rhesus monkeys (Macaca mulatta)

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Tubular cell senescence and expression of TGF-beta1 and p21(WAF1/CIP1) in tubulointerstitial fibrosis of aging rats

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Cellular senescence after single and repeated balloon catheter denudations of rabbit carotid arteries

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Telomere length and replicative aging in human vascular tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900053-5

7 January 2021

10.1016/S1357-2725(02)00053-5

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12200035