Cancer cells exhibit a mutator phenotype (Q41617067)

5 October 2017

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title

Cancer cells exhibit a mutator phenotype (English)

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5 October 2017

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Loeb LA

1

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5 October 2017

1 January 1998

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Advances in Cancer Research

5 October 2017

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5 October 2017

72

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5 October 2017

25-56

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Clues to the pathogenesis of familial colorectal cancer

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Frequent microsatellite instabilities and analyses of the related genes in familial gastric cancers.

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Nature's chemicals and synthetic chemicals: comparative toxicology

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The age distribution of cancer and a multi-stage theory of carcinogenesis

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Karyotypic evolution in human malignant melanoma

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Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole.

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7 January 2021

Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta.

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7 January 2021

Mutator phenotypes in human colorectal carcinoma cell lines

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7 January 2021

Metaphase chromosome anomaly: association with drug resistance and cell-specific products

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7 January 2021

A germline substitution in the human MSH2 gene is associated with high-grade dysplasia and cancer in ulcerative colitis

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7 January 2021

Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer.

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7 January 2021

Modification of DNA by reducing sugars: a possible mechanism for nucleic acid aging and age-related dysfunction in gene expression

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Mutational specificity of N-methyl-N-nitrosourea in the lacI gene of Escherichia coli

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The origin of human cancers

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7 January 2021

The origin of mutants

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7 January 2021

Thymine glycol and thymidine glycol in human and rat urine: a possible assay for oxidative DNA damage

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7 January 2021

Ha-ras-1 oncogene mutations in mammary epithelial cells do not contribute to initiation of spontaneous mammary tumorigenesis in rats.

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7 January 2021

Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver

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7 January 2021

Microsatellite alterations in plasma DNA of small cell lung cancer patients.

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7 January 2021

Bacterial mutator genes and the control of spontaneous mutation

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7 January 2021

Transcriptional activation by p53 correlates with suppression of growth but not transformation.

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7 January 2021

Microsatellite instability at multiple loci in gastric carcinoma: Clinicopathologic implications and prognosis

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7 January 2021

Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells

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7 January 2021

Cell cycle checkpoints: preventing an identity crisis

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7 January 2021

The Bloom's syndrome gene product is homologous to RecQ helicases

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A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process

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7 January 2021

5-Methylcytosine in eukaryotic DNA.

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7 January 2021

A genetic model for colorectal tumorigenesis

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7 January 2021

The origin and development of human tumors studied with cell markers

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7 January 2021

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

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7 January 2021

The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure

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7 January 2021

Mutator phenotype of Werner syndrome is characterized by extensive deletions

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7 January 2021

Bloom syndrome: an analysis of consanguineous families assigns the locus mutated to chromosome band 15q26.1

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7 January 2021

Selection-induced mutations occur in yeast

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7 January 2021

Adaptive mutations in Escherichia coli as a model for the multiple mutational origins of tumors

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7 January 2021

DNA Repair in Bacteria and Mammalian Cells

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7 January 2021

p53: at the crossroads of molecular carcinogenesis and risk assessment

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7 January 2021

Cell cycle control and cancer

1 reference

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7 January 2021

Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation

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7 January 2021

APC mutations in colorectal tumors with mismatch repair deficiency

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7 January 2021

Totipotency and normal differentiation of single teratocarcinoma cells cloned by injection into blastocysts

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7 January 2021

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

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7 January 2021

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

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7 January 2021

Mutation and cancer: statistical study of retinoblastoma

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7 January 2021

Fidelity of mammalian DNA polymerases

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7 January 2021

THE TIME DIMENSION IN HISTOLOGY

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Position independence and proper developmental control of gamma-globin gene expression require both a 5' locus control region and a downstream sequence element

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7 January 2021

Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs

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7 January 2021

Rate of depurination of native deoxyribonucleic acid

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7 January 2021

Heat-induced deamination of cytosine residues in deoxyribonucleic acid

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Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer

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7 January 2021

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

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7 January 2021

Apurinic sites as mutagenic intermediates

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7 January 2021

Errors in DNA synthesis: a source of spontaneous mutations

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7 January 2021

Mutations of the transforming growth factor-beta type II receptor gene and genomic instability in hereditary nonpolyposis colorectal cancer.

1 reference

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7 January 2021

Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype

1 reference

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7 January 2021

Proliferation of mutators in A cell population

1 reference

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7 January 2021

Molecular detection of primary bladder cancer by microsatellite analysis

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7 January 2021

Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives.

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7 January 2021

DNA polymerase beta gene mutations in human bladder cancer

1 reference

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7 January 2021

Mutagenic specificity of ultraviolet light

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7 January 2021

DNA mismatch correction

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7 January 2021

Mismatch repair, genetic stability and tumour avoidance

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7 January 2021

Mismatch repair in replication fidelity, genetic recombination, and cancer biology

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7 January 2021

Thymidine kinase mutants obtained by random sequence selection

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7 January 2021

Increased error frequency of DNA polymerases from senescent human fibroblasts

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7 January 2021

Microsatellite alterations in serum DNA of head and neck cancer patients

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7 January 2021

Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer

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7 January 2021

Mutations of two PMS homologues in hereditary nonpolyposis colon cancer

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7 January 2021

The clonal evolution of tumor cell populations

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7 January 2021

Ageing of Clones of Mammalian Cells

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7 January 2021

Mutations of GTBP in genetically unstable cells

1 reference

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7 January 2021

Mutation of a mutL homolog in hereditary colon cancer

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7 January 2021

Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction

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7 January 2021

Genetic mapping of a locus predisposing to human colorectal cancer

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7 January 2021

Loss of heterozygosity and base substitution at the APRT locus in mismatch-repair-proficient and -deficient colorectal carcinoma cell lines

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7 January 2021

Microsatellite instability in human non-melanoma and melanoma skin cancer

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7 January 2021

How many mutations are required for tumorigenesis? Implications from human cancer data

1 reference

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7 January 2021

A hPMS2 mutant cell line is defective in strand-specific mismatch repair

1 reference

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7 January 2021

Nonrandom chromosomal abnormalities in hematologic disorders of man

1 reference

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7 January 2021

Infidelity of DNA synthesis associated with bypass of apurinic sites

1 reference

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7 January 2021

High frequency mutagenesis by a DNA methyltransferase

1 reference

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7 January 2021

Somatic microsatellite mutations as molecular tumor clocks

1 reference

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7 January 2021

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1 reference

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7 January 2021

Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage

1 reference

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7 January 2021

Frequent co-occurrence of mutator phenotype in synchronous, independent multiple cancers of the stomach

1 reference

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7 January 2021

Lack of the DNA repair protein O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors

1 reference

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7 January 2021

Evidence for the mutagenic potential of the vinyl chloride induced adduct, N2, 3-etheno-deoxyguanosine, using a site-directed kinetic assay

1 reference

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7 January 2021

Identifying tumor suppressor genes in human colorectal cancer

1 reference

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7 January 2021

Cell cycle control of DNA replication.

1 reference

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7 January 2021

Characterization of DNA polymeraseβ mutants with amino acid substitutions located in the C-terminal portion of the enzyme

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7 January 2021

Incidence of cancer in 161 families affected by ataxia-telangiectasia

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7 January 2021

Microsatellite instability in cancer of the proximal colon

1 reference

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7 January 2021

Suppression of gene amplification in human cell hybrids

1 reference

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7 January 2021

The mutation rate and cancer

1 reference

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7 January 2021

Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis

1 reference

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7 January 2021

Genetic alterations during colorectal-tumor development

1 reference

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7 January 2021

Tumor suppressor genes

1 reference

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7 January 2021

Positional cloning of the Werner's syndrome gene

1 reference

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7 January 2021

Foundations in cancer research. Chromosomes and cancer: the evolution of an idea.

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7 January 2021

10.1016/S0065-230X(08)60699-5

Identifiers

DOI

0 references

PubMed ID

9338073

1 reference

PubMed ID

9338073