The hypoxia-inducible factor and tumor progression along the angiogenic pathway. (Q34376363)

1 August 2017

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title

The hypoxia-inducible factor and tumor progression along the angiogenic pathway. (English)

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1 August 2017

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2

Jacques Pouysségur

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1 August 2017

M Christiane Brahimi-Horn

series ordinal

1

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1 August 2017

1 January 2005

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International Review of Cytology

1 August 2017

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1 August 2017

242

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1 August 2017

157-213

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Ubiquitin: not just for proteasomes anymore

1 August 2017

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https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Jab1 interacts directly with HIF-1alpha and regulates its stability

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Expression of HIF-2alpha/EPAS1 in hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Regulation of gene expression by transcription factor acetylation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

1 reference

7 January 2021

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The subtle side to hypoxia inducible factor (HIFalpha) regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity

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https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alpha

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https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The hypoxic response of tumors is dependent on their microenvironment.

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https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications

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https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Signal Transduction and the Control of Gene Expression

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https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Exploiting tumour hypoxia in cancer treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Significant correlation of hypoxia-inducible factor-1alpha with treatment outcome in cervical cancer treated with radical radiotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Angiogenesis in health and disease

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https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The diverse functions of histone acetyltransferase complexes.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Definition of a minimal domain of the dioxin receptor that is associated with Hsp90 and maintains wild type ligand binding affinity and specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The bHLH/PAS factor MOP3 does not participate in hypoxia responses

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

HIF-1alpha is essential for myeloid cell-mediated inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Control of cell lineage-specific development and transcription by bHLH-PAS proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Remembrance of things PAS: regulation of development by bHLH-PAS proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Endogenous 2-oxoacids differentially regulate expression of oxygen sensors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Three conformational states of the p300 CH1 domain define its functional properties

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Cloning and selective expression in brain and kidney of ARNT2 homologous to the Ah receptor nuclear translocator (ARNT).

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Two splice variants of the hypoxia-inducible factor HIF-1alpha as potential dimerization partners of ARNT2 in neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Inhibition of transcription elongation by the VHL tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Falkor, a novel cell growth regulator isolated by a functional genetic screen

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Hypoxia-dependent regulation of PHD1: cloning and characterization of the human PHD1/EGLN2 gene promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

NATH, a novel gene overexpressed in papillary thyroid carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Cancer: looking outside the genome

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth

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https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Regulating the regulators: lysine modifications make their mark

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https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Characterization of xenobiotic responsive elements upstream from the drug-metabolizing cytochrome P-450c gene: a similarity to glucocorticoid regulatory elements

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Identification of functional domains of the aryl hydrocarbon receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Hypoxia inhibits G1/S transition through regulation of p27 expression

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Hypoxia-inducible factor 1 alpha in high-risk breast cancer: an independent prognostic parameter?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The discovery of receptor tyrosine kinases: targets for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The PAS superfamily: sensors of environmental and developmental signals

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

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https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Oxygen sensing and oxidant/redox-related pathways

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https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The aryl hydrocarbon receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The PAS fold. A redefinition of the PAS domain based upon structural prediction

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Expression of the von Hippel-Lindau-binding protein-1 (Vbp1) in fetal and adult mouse tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Nuclear localization and export signals of the human aryl hydrocarbon receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Tumour suppression by the human von Hippel-Lindau gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Integrative annotation of 21,037 human genes validated by full-length cDNA clones

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1alpha by modulating an Hsp90-dependent regulatory pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

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https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Deadly encounter: ubiquitin meets apoptosis

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https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Expression of vascular endothelial growth factor, hypoxia inducible factor 1alpha, and carbonic anhydrase IX in human tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Molecular basis of the VHL hereditary cancer syndrome

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https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Clinical translation of angiogenesis inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The mammalian basic helix-loop-helix/PAS family of transcriptional regulators

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Clinicopathological significance of hypoxia-inducible factor-1alpha expression in human pancreatic carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

10 Posttranslational enzymes in the biosynthesis of collagen: Intracellular enzymes

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https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Susceptibility to vascular neoplasms but no increased susceptibility to renal carcinogenesis in Vhl knockout mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

1 reference

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7 January 2021

Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death

1 reference

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7 January 2021

Hypoxia-activated tumor pathways of angiogenesis and pH regulation independent of anemia in head-and-neck cancer.

1 reference

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7 January 2021

Acetylation: a regulatory modification to rival phosphorylation?

1 reference

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7 January 2021

ARNT-deficient mice and placental differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Xenobiotic Responsive Element in the 5′-Upstream Region of the Human P-450c Gene1

1 reference

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7 January 2021

Suppression of tumor growth through disruption of hypoxia-inducible transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Cardiac expressions of HIF-1 alpha and HLF/EPAS, two basic loop helix/PAS domain transcription factors involved in adaptative responses to hypoxic stresses

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau

1 reference

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7 January 2021

Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway

1 reference

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7 January 2021

Role of nuclear and cytoplasmic localization in the tumour-suppressor activity of the von Hippel-Lindau protein.

1 reference

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7 January 2021

Role of the C-terminal alpha-helical domain of the von Hippel-Lindau protein in its E3 ubiquitin ligase activity.

1 reference

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7 January 2021

Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha

1 reference

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7 January 2021

Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein

1 reference

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7 January 2021

Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor

1 reference

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7 January 2021

The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity

1 reference

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7 January 2021

Mammalian EGLN genes have distinct patterns of mRNA expression and regulation

1 reference

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7 January 2021

Serological identification and expression analysis of gastric cancer-associated genes

1 reference

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7 January 2021

Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor

1 reference

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7 January 2021

SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons

1 reference

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7 January 2021

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

1 reference

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7 January 2021

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

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7 January 2021

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

1 reference

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7 January 2021

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

1 reference

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7 January 2021

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

1 reference

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7 January 2021

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

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7 January 2021

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.

1 reference

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7 January 2021

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels

1 reference

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7 January 2021

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

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7 January 2021

Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways.

1 reference

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7 January 2021

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

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7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Activation of the HIF pathway in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

HIF-1: master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs

1 reference

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7 January 2021

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

HIF activation by pH-dependent nucleolar sequestration of VHL.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Regulation of the SM-20 prolyl hydroxylase gene in smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

How the ubiquitin-proteasome system controls transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein

1 reference

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7 January 2021

Hypoxia-inducible factor 1 alpha (HIF-1 alpha) gene expression in human ovarian carcinoma

1 reference

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7 January 2021

Autosomal dominant malignant and catecholamine-producing paraganglioma caused by a splice donor site mutation in SDHC.

1 reference

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7 January 2021

The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

1 reference

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7 January 2021

Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Tubedown-1 in remodeling of the developing vitreal vasculature in vivo and regulation of capillary outgrowth in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

HIF at the crossroads between ischemia and carcinogenesis

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7 January 2021

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Proteasomes and their kin: proteases in the machine age

1 reference

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7 January 2021

Identification and functional characterization of hypoxia-inducible factor 2alpha from the estuarine teleost, Fundulus heteroclitus: interaction of HIF-2alpha with two ARNT2 splice variants

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Why is p53 acetylated?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Angiogenesis and G-protein-coupled receptors: signals that bridge the gap.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation. Identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300

1 reference

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7 January 2021

A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Oxygen sensing by HIF hydroxylases

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Nuclear and unclear functions of SUMO

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

HIF-1 and tumor progression: pathophysiology and therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Targeting HIF-1 for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene

1 reference

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7 January 2021

Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.

1 reference

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7 January 2021

Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Pretreatment evaluation of combined HIF-1alpha, p53 and p21 expression is a useful and sensitive indicator of response to radiation and chemotherapy in esophageal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Expression of the cell death genes BNip3 and NIX in ductal carcinoma in situ of the breast; correlation of BNip3 levels with necrosis and grade

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

HIF-1 alpha protein as a target for S-nitrosation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Characterization and comparative analysis of the EGLN gene family

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Purification and characterization of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

On the Origin of Cancer Cells

1 reference

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7 January 2021

Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Aryl hydrocarbon (Ah) nonresponsiveness in estrogen receptor-negative MDA-MB-231 cells is associated with expression of a variant arnt protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

DNA sequence determinants for binding of transformed Ah receptor to a dioxin-responsive enhancer

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

S-nitrosation of Cys-800 of HIF-1alpha protein activates its interaction with p300 and stimulates its transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Expression of hypoxia-inducible factor 1? in brain tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia inducible factor-1alpha through a nuclear factor-kappaB-dependent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

Cancer metabolism: facts, fantasy, and fiction

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https://api.crossref.org/works/10.1016%2FS0074-7696%2804%2942004-X

7 January 2021

10.1016/S0074-7696(04)42004-X

Identifiers

DOI

1 reference

1 August 2017

1 reference

PubMed ID

15598469