The discovery of receptor tyrosine kinases: targets for cancer therapy (Q44879898)

7 December 2017

title

The discovery of receptor tyrosine kinases: targets for cancer therapy (English)

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7 December 2017

Andreas Gschwind

1

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7 December 2017

Oliver M Fischer

series ordinal

2

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7 December 2017

Axel Ullrich

series ordinal

3

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7 December 2017

publication date

1 May 2004

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7 December 2017

language of work or name

English

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published in

Nature Reviews Cancer

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7 December 2017

volume

4

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7 December 2017

issue

5

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7 December 2017

page(s)

361-370

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publication type of scholarly work

7 December 2017

review article

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Effects of mouse tumor transplantation on the nervous system

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Critical Role of Calcium- dependent Epidermal Growth Factor Receptor Transactivation in PC12 Cell Membrane Depolarization and Bradykinin Signaling

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Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

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EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

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TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

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Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

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Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells

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cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells

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Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

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Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

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An essential role for ectodomain shedding in mammalian development

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Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability

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c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

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Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl

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Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene

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Amplification of a novel v-erbB-related gene in a human mammary carcinoma

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Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody

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Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

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31 March 2020

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31 March 2020

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A specific inhibitor of the epidermal growth factor receptor tyrosine kinase

31 March 2020

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Epidermal‐Growth‐Factor‐Dependent Activation of the Src‐Family Kinases

31 March 2020

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Specific inhibition of epidermal growth factor receptor tyrosine kinase by 4-anilinoquinazolines

31 March 2020

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

31 March 2020

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Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor

31 March 2020

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VEGF and the quest for tumour angiogenesis factors

31 March 2020

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Transplacental carcinogenesis by stilbestrol

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The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

31 March 2020

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Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

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High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

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Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium

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Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

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Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

31 March 2020

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Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

31 March 2020

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SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo

31 March 2020

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

31 March 2020

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Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor

31 March 2020

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Mutational analysis of the tyrosine kinome in colorectal cancers

31 March 2020

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Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

31 March 2020

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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

31 March 2020

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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1360

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7 December 2017

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