Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein (Q44043145)

29 November 2017

title

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein (English)

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29 November 2017

5

William G Kaelin

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29 November 2017

Keiichi Kondo

1

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29 November 2017

Jeff Klco

series ordinal

2

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29 November 2017

Eijiro Nakamura

series ordinal

3

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29 November 2017

Mirna Lechpammer

series ordinal

4

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29 November 2017

publication date

1 April 2002

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29 November 2017

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29 November 2017

volume

1

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29 November 2017

issue

3

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29 November 2017

page(s)

237-246

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Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal

29 November 2017

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Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

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Up-Regulation of Vascular Endothelial Growth Factor in Stromal Cells of Hemangioblastomas Is Correlated with Up-Regulation of the Transcription Factor HRF/HIF-2α

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7 January 2021

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

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von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

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pVHL 19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation

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7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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7 January 2021

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

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7 January 2021

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

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7 January 2021

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Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

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7 January 2021

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7 January 2021

Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2

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7 January 2021

von Hippel-Lindau Disease

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7 January 2021

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

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7 January 2021

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

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7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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7 January 2021

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Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein

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7 January 2021

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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7 January 2021

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

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7 January 2021

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7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

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7 January 2021

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

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7 January 2021

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

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7 January 2021

Germline and somatic mutations in von Hippel-Lindau disease gene and its significance in the development of kidney cancer

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7 January 2021

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

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7 January 2021

Putative Control of Angiogenesis in Hemangioblastomas by the von Hippel-Lindau Tumor Suppressor Gene

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7 January 2021

Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor

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7 January 2021

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

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7 January 2021

von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease

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7 January 2021

Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma

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7 January 2021

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

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7 January 2021

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Identifiers

DOI

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29 November 2017

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